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Academic Journal

Targeting Aggrecanases for Osteoarthritis Therapy: From Zinc Chelation to Exosite Inhibition.

  • Authors : Cuffaro D; Department of Pharmacy, University of Pisa, via Bonanno 6, 56126 Pisa, Italy.; Ciccone L

Subjects: Procollagen N-Endopeptidase*/Procollagen N-Endopeptidase*/Procollagen N-Endopeptidase*/metabolism ; Osteoarthritis*/Osteoarthritis*/Osteoarthritis*/metabolism; Humans

  • Source: Journal of medicinal chemistry [J Med Chem] 2022 Oct 27; Vol. 65 (20), pp. 13505-13532. Date of Electronic Publication: 2022 Oct 17.Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

The "elusive DMOAD": Aggrecanase inhibition from laboratory to clinic.

  • Authors : Malfait AM; Rush University Medical School, Department of Medicine, Division of Rheumatology, Chicago IL, USA. .; Tortorella MD

Subjects: ADAM Proteins*/ADAM Proteins*/ADAM Proteins*/antagonists & inhibitors ; ADAM Proteins*/ADAM Proteins*/ADAM Proteins*/immunology ; Procollagen N-Endopeptidase*

  • Source: Clinical and experimental rheumatology [Clin Exp Rheumatol] 2019 Sep-Oct; Vol. 37 Suppl 120 (5), pp. 130-134. Date of Electronic Publication: 2019 Oct 15.Publisher: Clinical And Experimental Rheumatology S.A.S Country of Publication: Italy NLM ID: 8308521 Publication Model: Print-Electronic Cited Medium:

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Academic Journal

ADAMTS-4_v1 is a splice variant of ADAMTS-4 that is expressed as a protein in human synovium and cleaves aggrecan at the interglobular domain.

Subjects: ADAM Proteins/ADAM Proteins/ADAM Proteins/*genetics ; ADAM Proteins/ADAM Proteins/ADAM Proteins/*metabolism ; Aggrecans/Aggrecans/Aggrecans/*metabolism

  • Source: Arthritis and rheumatism [Arthritis Rheum] 2013 Nov; Vol. 65 (11), pp. 2866-75.Publisher: Wiley-Blackwell Country of Publication: United States NLM ID: 0370605 Publication Model: Print Cited Medium: Internet ISSN: 1529-0131

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Academic Journal

Current and emerging therapeutic strategies for preventing inflammation and aggrecanase-mediated cartilage destruction in arthritis.

  • Authors : Dancevic CM; School of Medicine and Molecular and Medical Research SRC, Faculty of Health, Deakin University, 75 Pigdons Road, Waurn Ponds 3216, VIC, Australia.; McCulloch DR

Subjects: ADAM Proteins/ADAM Proteins/ADAM Proteins/*antagonists & inhibitors ; Arthritis, Rheumatoid/Arthritis, Rheumatoid/Arthritis, Rheumatoid/*drug therapy ; Cartilage/Cartilage/Cartilage/*drug effects

  • Source: Arthritis research & therapy [Arthritis Res Ther] 2014; Vol. 16 (5), pp. 429.Publisher: BioMed Central Country of Publication: England NLM ID: 101154438 Publication Model: Print Cited Medium: Internet ISSN: 1478-6362

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Academic Journal

Tumor necrosis factor-α induces ADAMTS-4 expression in human osteoarthritis chondrocytes.

  • Authors : Xue J; Department of Urology, Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, P.R. China.; Wang J

Subjects: ADAM Proteins/ADAM Proteins/ADAM Proteins/*genetics ; Chondrocytes/Chondrocytes/Chondrocytes/*metabolism ; Chondrocytes/Chondrocytes/Chondrocytes/*pathology

  • Source: Molecular medicine reports [Mol Med Rep] 2013 Dec; Vol. 8 (6), pp. 1755-60. Date of Electronic Publication: 2013 Oct 14.Publisher: D. A. Spandidos Country of Publication: Greece NLM ID: 101475259 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

[Research progress of a disintegrin and metalloproteinase with thrombospondin motif 4 and 5 in osteoarthritis].

  • Authors : Ji Q; Department of Orthopedics, the General Hospital of Chinese PLA, Beijing, 100853, P.R.China.; Zhang Q

Subjects: ADAM Proteins/ADAM Proteins/ADAM Proteins/*metabolism ; Aggrecans/Aggrecans/Aggrecans/*metabolism ; Osteoarthritis/Osteoarthritis/Osteoarthritis/*enzymology

  • Source: Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery [Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi] 2013 Publisher: Hua xi yi ke da xue Fu shu di 1 yi yuan Country of Publication: China NLM ID: 9425194 Publication Model: Print Cited Medium: Print ISSN:

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Academic Journal

Detection of ADAMTS-4 activity using a fluorogenic peptide-conjugated Au nanoparticle probe in human knee synovial fluid.

  • Authors : Peng S; Institute of Sports Medicine, Peking University Third Hospital, Haidian District, Beijing, P R China.; Zheng Q

Subjects: ADAM Proteins/ADAM Proteins/ADAM Proteins/*analysis ; Enzyme Assays/Enzyme Assays/Enzyme Assays/*methods ; Knee Joint/Knee Joint/Knee Joint/*enzymology

  • Source: ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2013 Jul 10; Vol. 5 (13), pp. 6089-96. Date of Electronic Publication: 2013 Jun 24.Publisher: American Chemical Society Country of Publication: United States NLM ID: 101504991 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Arylsulfonamide inhibitors of aggrecanases as potential therapeutic agents for osteoarthritis: synthesis and biological evaluation.

  • Authors : Nuti E; Dipartimento di Farmacia, Università di Pisa, via Bonanno 6, 56126 Pisa, Italy.; Santamaria S

Subjects: ADAM Proteins/ADAM Proteins/ADAM Proteins/*antagonists & inhibitors ; Matrix Metalloproteinase Inhibitors/Matrix Metalloproteinase Inhibitors/Matrix Metalloproteinase Inhibitors/*pharmacology ; Matrix Metalloproteinases/Matrix Metalloproteinases/Matrix Metalloproteinases/*metabolism

  • Source: European journal of medicinal chemistry [Eur J Med Chem] 2013 Apr; Vol. 62, pp. 379-94. Date of Electronic Publication: 2013 Jan 11.Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

MMP proteolysis of the human extracellular matrix protein aggrecan is mainly a process of normal turnover.

  • Authors : Struglics A; Department of Orthopaedics, Clinical Sciences Lund, Lund University, Lund, Sweden. ; Hansson M

Subjects: ADAM Proteins/ADAM Proteins/ADAM Proteins/*metabolism ; Aggrecans/Aggrecans/Aggrecans/*metabolism ; Cartilage, Articular/Cartilage, Articular/Cartilage, Articular/*metabolism

  • Source: The Biochemical journal [Biochem J] 2012 Sep 01; Vol. 446 (2), pp. 213-23.Publisher: Published by Portland Press on behalf of the Biochemical Society Country of Publication: England NLM ID: 2984726R Publication Model: Print Cited

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Academic Journal

[Aggrecanases and osteoarthritis].

  • Authors : Li C; Department of Biomedical Engineering, Peking University College of Engineering, Beijing 100871, China.; Cao YP

Subjects: Endopeptidases*/Endopeptidases*/Endopeptidases*/chemistry ; Endopeptidases*/Endopeptidases*/Endopeptidases*/metabolism; ADAM Proteins/ADAM Proteins/ADAM Proteins/*metabolism

  • Source: Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences [Beijing Da Xue Xue Bao Yi Xue Ban] 2009 Oct 18; Vol. 41 (5), pp. 611-2.Publisher: Beijing da xue Country of Publication: China NLM ID: 101125284 Publication Model: Print Cited Medium: Print ISSN: 1671-167X (Print)

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  • 1-10 of  65 results for ""Procollagen N-Endopeptidase""