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Academic Journal

Disabling the Protease DDI2 Attenuates the Transcriptional Activity of NRF1 and Potentiates Proteasome Inhibitor Cytotoxicity.

  • Authors : Northrop A; Department of Pathology and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA.; Vangala JR

Subjects: Aspartic Acid Proteases/Aspartic Acid Proteases/Aspartic Acid Proteases/*metabolism ; Nuclear Respiratory Factor 1/Nuclear Respiratory Factor 1/Nuclear Respiratory Factor 1/*metabolism ; Oligopeptides/Oligopeptides/Oligopeptides/*pharmacology

  • Source: International journal of molecular sciences [Int J Mol Sci] 2020 Jan 03; Vol. 21 (1). Date of Electronic Publication: 2020 Jan 03.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

Crystal structures of multidrug-resistant HIV-1 protease in complex with two potent anti-malarial compounds.

  • Authors : Yedidi RS; Department of Biochemistry and Molecular Biology, School of Medicine, Wayne State University, 540 E. Canfield Avenue, Detroit, MI 48201, USA. ; Liu Z

Subjects: Drug Resistance, Multiple, Viral*; Antimalarials/Antimalarials/Antimalarials/*chemistry ; Aspartic Acid Proteases/Aspartic Acid Proteases/Aspartic Acid Proteases/*chemistry

  • Source: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2012 May 11; Vol. 421 (3), pp. 413-7. Date of Electronic Publication: 2012 Mar 24.Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Plasmepsin V, a secret weapon against malaria.

  • Authors : Sedwick C; Freelance Science Writer, San Diego, California, United States of America.

Subjects: Aspartic Acid Endopeptidases/Aspartic Acid Endopeptidases/Aspartic Acid Endopeptidases/*antagonists & inhibitors ; Aspartic Acid Proteases/Aspartic Acid Proteases/Aspartic Acid Proteases/*antagonists & inhibitors ; Oligopeptides/Oligopeptides/Oligopeptides/*pharmacology

  • Source: PLoS biology [PLoS Biol] 2014 Jul 01; Vol. 12 (7), pp. e1001898. Date of Electronic Publication: 2014 Jul 01 (Print Publication: 2014).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101183755 Publication Model: eCollection Cited Medium: Internet

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Academic Journal

Inhibition of Plasmepsin V activity demonstrates its essential role in protein export, PfEMP1 display, and survival of malaria parasites.

  • Authors : Sleebs BE; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia; Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia.

Subjects: Aspartic Acid Endopeptidases/Aspartic Acid Endopeptidases/Aspartic Acid Endopeptidases/*antagonists & inhibitors ; Aspartic Acid Proteases/Aspartic Acid Proteases/Aspartic Acid Proteases/*antagonists & inhibitors ; Oligopeptides/Oligopeptides/Oligopeptides/*pharmacology

  • Source: PLoS biology [PLoS Biol] 2014 Jul 01; Vol. 12 (7), pp. e1001897. Date of Electronic Publication: 2014 Jul 01 (Print Publication: 2014).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101183755 Publication Model: eCollection Cited Medium: Internet

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Academic Journal

pH-Dependent Population Shift Regulates BACE1 Activity and Inhibition.

  • Authors : Ellis CR; Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland 21201, United States.; Shen J

Subjects: Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/*antagonists & inhibitors ; Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/*metabolism ; Aspartic Acid Endopeptidases/Aspartic Acid Endopeptidases/Aspartic Acid Endopeptidases/*antagonists & inhibitors

  • Source: Journal of the American Chemical Society [J Am Chem Soc] 2015 Aug 05; Vol. 137 (30), pp. 9543-6. Date of Electronic Publication: 2015 Jul 22.Publisher: American Chemical Society Country of Publication: United States NLM ID: 7503056 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Design, synthesis and biological evaluation of tasiamide B derivatives as BACE1 inhibitors.

  • Authors : Liu J; School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, China.; Chen W

Subjects: Drug Design*; Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/*antagonists & inhibitors ; Aspartic Acid Endopeptidases/Aspartic Acid Endopeptidases/Aspartic Acid Endopeptidases/*antagonists & inhibitors

  • Source: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2015 May 01; Vol. 23 (9), pp. 1963-74. Date of Electronic Publication: 2015 Mar 20.Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Lower homologues of ahpatinin, aspartic protease inhibitors, from a marine Streptomyces sp.

  • Authors : Sun Y; Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo , Bunkyo-ku, Tokyo 113-8657, Japan.; Takada K

Subjects: Aspartic Acid Endopeptidases/Aspartic Acid Endopeptidases/Aspartic Acid Endopeptidases/*antagonists & inhibitors ; Oligopeptides/Oligopeptides/Oligopeptides/*isolation & purification ; Oligopeptides/Oligopeptides/Oligopeptides/*pharmacology

  • Source: Journal of natural products [J Nat Prod] 2014 Jul 25; Vol. 77 (7), pp. 1749-52. Date of Electronic Publication: 2014 Jun 24.Publisher: American Society of Pharmacognosy Country of Publication: United States NLM ID: 7906882 Publication Model: Print-Electronic Cited Medium:

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Academic Journal

Tripeptidic BACE1 inhibitors devised by in-silico conformational structure-based design.

  • Authors : Hamada Y; Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Minatojima, Chuo-ku, Kobe 650-8586, Japan; Center for Frontier Research in Medicinal Science, Kyoto Pharmaceutical University, Yamashina-ku, Kyoto 607-8412, Japan.

Subjects: Drug Design*; Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/*antagonists & inhibitors ; Aspartic Acid Endopeptidases/Aspartic Acid Endopeptidases/Aspartic Acid Endopeptidases/*antagonists & inhibitors

  • Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2012 Jan 15; Vol. 22 (2), pp. 1130-5. Date of Electronic Publication: 2011 Dec 01.Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Tetrapeptides, as small-sized peptidic inhibitors; synthesis and their inhibitory activity against BACE1.

  • Authors : Kakizawa T; Department of Medicinal Chemistry, Center for Frontier Research in Medicinal Science, Kyoto Pharmaceutical University, Yamashina-ku, Kyoto, Japan.; Hidaka K

Subjects: Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/*antagonists & inhibitors ; Aspartic Acid Endopeptidases/Aspartic Acid Endopeptidases/Aspartic Acid Endopeptidases/*antagonists & inhibitors ; Oligopeptides/Oligopeptides/Oligopeptides/*metabolism

  • Source: Journal of peptide science : an official publication of the European Peptide Society [J Pept Sci] 2010 Jun; Vol. 16 (6), pp. 257-62.Publisher: John Wiley & Sons Country of Publication: England NLM ID: 9506309 Publication Model: Print Cited Medium: Internet ISSN: 1099-1387

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Academic Journal

Design of pentapeptidic BACE1 inhibitors with carboxylic acid bioisosteres at P1' and P4 positions.

  • Authors : Tagad HD; Department of Medicinal Chemistry, Centre Frontier Research in Medicinal Science, Kyoto Pharmaceutical University, Yamashina-Ku, Kyoto 607-8412, Japan.; Hamada Y

Subjects: Drug Design* ; Enzyme Inhibitors*/Enzyme Inhibitors*/Enzyme Inhibitors*/chemical synthesis ; Enzyme Inhibitors*/Enzyme Inhibitors*/Enzyme Inhibitors*/chemistry

  • Source: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2010 May 01; Vol. 18 (9), pp. 3175-86. Date of Electronic Publication: 2010 Mar 21.Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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  • 1-10 of  161 results for ""Aspartic Acid Proteases""