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Academic Journal

Hydrophilic interaction liquid chromatography with mass spectrometry for the separation and identification of antisense oligonucleotides impurities and nusinersen metabolites.

  • Authors : Vosáhlová Z; Department of Physical and Macromolecular Chemistry, Faculty of Science, Charles University, Hlavova 8, 12800, Prague, Czech Republic.; Kalíková K

Subjects: Oligonucleotides, Antisense* ; Phosphorothioate Oligonucleotides*; Humans

  • Source: Journal of chromatography. A [J Chromatogr A] 2024 Jan 04; Vol. 1713, pp. 464535. Date of Electronic Publication: 2023 Nov 26.Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9318488 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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NAT10 and DDX21 Proteins Interact with RNase H1 and Affect the Performance of Phosphorothioate Oligonucleotides.

  • Authors : Zhang L; Department of Core Antisense Research, Ionis Pharmaceuticals, Inc., Carlsbad, California, USA.; Bernardo KD

Subjects: Oligonucleotides, Antisense*/Oligonucleotides, Antisense*/Oligonucleotides, Antisense*/genetics ; Oligonucleotides, Antisense*/Oligonucleotides, Antisense*/Oligonucleotides, Antisense*/metabolism ; Phosphorothioate Oligonucleotides*/Phosphorothioate Oligonucleotides*/Phosphorothioate Oligonucleotides*/genetics

  • Source: Nucleic acid therapeutics [Nucleic Acid Ther] 2022 Aug; Vol. 32 (4), pp. 280-299. Date of Electronic Publication: 2022 Jul 18.Publisher: Mary Ann Liebert, Inc Country of Publication: United States NLM ID: 101562758 Publication Model: Print-Electronic Cited Medium: Internet

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Controlled sulfur-based engineering confers mouldability to phosphorothioate antisense oligonucleotides.

  • Authors : Genna V; Mechanisms of Diseases, Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Baldiri Reixac 10-12, Barcelona 08028, Spain.; NBD | Nostrum Biodiscovery, Baldiri Reixac 10, Barcelona 08028, Spain.

Subjects: Phosphorothioate Oligonucleotides*/Phosphorothioate Oligonucleotides*/Phosphorothioate Oligonucleotides*/chemistry ; Oligonucleotides, Antisense*/Oligonucleotides, Antisense*/Oligonucleotides, Antisense*/chemistry; Humans

  • Source: Nucleic acids research [Nucleic Acids Res] 2023 Jun 09; Vol. 51 (10), pp. 4713-4725.Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN:

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Academic Journal

The Combination of Mesyl-Phosphoramidate Inter-Nucleotide Linkages and 2'- O -Methyl in Selected Positions in the Antisense Oligonucleotide Enhances the Performance of RNaseH1 Active PS-ASOs.

  • Authors : Zhang L; Department of Core Antisense Research, Ionis Pharmaceuticals, Inc., Carlsbad, California, USA.; Liang XH

Subjects: Oligonucleotides, Antisense*/Oligonucleotides, Antisense*/Oligonucleotides, Antisense*/genetics ; Oligonucleotides, Antisense*/Oligonucleotides, Antisense*/Oligonucleotides, Antisense*/pharmacology ; Oligonucleotides, Antisense*/Oligonucleotides, Antisense*/Oligonucleotides, Antisense*/chemistry

  • Source: Nucleic acid therapeutics [Nucleic Acid Ther] 2022 Oct; Vol. 32 (5), pp. 401-411. Date of Electronic Publication: 2022 Jul 20.Publisher: Mary Ann Liebert, Inc Country of Publication: United States NLM ID: 101562758 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Binding of phosphorothioate oligonucleotides with RNase H1 can cause conformational changes in the protein and alter the interactions of RNase H1 with other proteins.

  • Authors : Zhang L; Core Antisense Research, Ionis Pharmaceuticals, Inc., 2855 Gazelle Court, Carlsbad, CA 92010, USA.; Vickers TA

Subjects: Oligonucleotides, Antisense/Oligonucleotides, Antisense/Oligonucleotides, Antisense/*metabolism ; Phosphorothioate Oligonucleotides/Phosphorothioate Oligonucleotides/Phosphorothioate Oligonucleotides/*metabolism ; Ribonuclease H/Ribonuclease H/Ribonuclease H/*metabolism

  • Source: Nucleic acids research [Nucleic Acids Res] 2021 Mar 18; Vol. 49 (5), pp. 2721-2739.Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN:

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Academic Journal

Insights into innate immune activation via PS-ASO-protein-TLR9 interactions.

  • Authors : Pollak AJ; Ionis Pharmaceuticals, Inc. Carlsbad, CA 92010, USA.; Zhao L

Subjects: Immunity, Innate* ; Oligonucleotides, Antisense*/Oligonucleotides, Antisense*/Oligonucleotides, Antisense*/metabolism ; Phosphorothioate Oligonucleotides*/Phosphorothioate Oligonucleotides*/Phosphorothioate Oligonucleotides*/metabolism

  • Source: Nucleic acids research [Nucleic Acids Res] 2022 Aug 12; Vol. 50 (14), pp. 8107-8126.Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN:

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An LNA-amide modification that enhances the cell uptake and activity of phosphorothioate exon-skipping oligonucleotides.

  • Authors : Baker YR; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1 3TA, UK.; Thorpe C

Subjects: Oligonucleotides, Antisense*/Oligonucleotides, Antisense*/Oligonucleotides, Antisense*/genetics ; Phosphorothioate Oligonucleotides*; Amides

  • Source: Nature communications [Nat Commun] 2022 Jul 12; Vol. 13 (1), pp. 4036. Date of Electronic Publication: 2022 Jul 12.Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

2'- O -( N -(Aminoethyl)carbamoyl)methyl Modification Allows for Lower Phosphorothioate Content in Splice-Switching Oligonucleotides with Retained Activity.

  • Authors : Honcharenko D; Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden.; Rocha CSJ

Subjects: Oligonucleotides, Antisense*/Oligonucleotides, Antisense*/Oligonucleotides, Antisense*/chemistry ; Oligonucleotides, Antisense*/Oligonucleotides, Antisense*/Oligonucleotides, Antisense*/genetics ; Phosphorothioate Oligonucleotides*/Phosphorothioate Oligonucleotides*/Phosphorothioate Oligonucleotides*/chemistry

  • Source: Nucleic acid therapeutics [Nucleic Acid Ther] 2022 Jun; Vol. 32 (3), pp. 221-233. Date of Electronic Publication: 2022 Mar 02.Publisher: Mary Ann Liebert, Inc Country of Publication: United States NLM ID: 101562758 Publication Model: Print-Electronic Cited Medium: Internet

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Control of backbone chemistry and chirality boost oligonucleotide splice switching activity.

Subjects: Muscular Dystrophy, Duchenne*/Muscular Dystrophy, Duchenne*/Muscular Dystrophy, Duchenne*/drug therapy ; Muscular Dystrophy, Duchenne*/Muscular Dystrophy, Duchenne*/Muscular Dystrophy, Duchenne*/therapy; Oligonucleotides, Antisense/Oligonucleotides, Antisense/Oligonucleotides, Antisense/*chemistry

  • Source: Nucleic acids research [Nucleic Acids Res] 2022 Jun 10; Vol. 50 (10), pp. 5443-5466.Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN:

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Evaluation of Phosphorus and Non-Phosphorus Neutral Oligonucleotide Backbones for Enhancing Therapeutic Index of Gapmer Antisense Oligonucleotides.

  • Authors : Vasquez G; Department of Medicinal Chemistry, Ionis Pharmaceuticals, Carlsbad, California, USA.; Migawa MT

Subjects: Oligonucleotides, Antisense*/Oligonucleotides, Antisense*/Oligonucleotides, Antisense*/genetics ; Oligonucleotides, Antisense*/Oligonucleotides, Antisense*/Oligonucleotides, Antisense*/metabolism ; Oligonucleotides, Antisense*/Oligonucleotides, Antisense*/Oligonucleotides, Antisense*/therapeutic use

  • Source: Nucleic acid therapeutics [Nucleic Acid Ther] 2022 Feb; Vol. 32 (1), pp. 40-50. Date of Electronic Publication: 2021 Oct 25.Publisher: Mary Ann Liebert, Inc Country of Publication: United States NLM ID: 101562758 Publication Model: Print-Electronic Cited Medium: Internet

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  • 1-10 of  379 results for ""Phosphorothioate Oligonucleotides""