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Academic Journal

Pathological manifestation of the induced pluripotent stem cell‐derived cortical neurons from an early‐onset Alzheimer's disease patient carrying a presenilin‐1 mutation (S170F).

Subjects: ALZHEIMER'S patients; PLURIPOTENT stem cells; INDUCED pluripotent stem cells

  • Source: Cell Proliferation. Apr2020, Vol. 53 Issue 4, p1-12. 12p.

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Academic Journal

Presenilin-1 F105C mutation leads to tau accumulation in human neurons via the Akt/mTORC1 signaling pathway.

Subjects: NEUROFIBRILLARY tangles; INDUCED pluripotent stem cells; LYSOSOMES

  • Source: Cell & Bioscience; 8/14/2022, Vol. 12 Issue 1, p1-15, 15p

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Academic Journal

Twenty Years of Presenilins--Important Proteins in Health and Disease.

  • Authors : Walter J; Department of Neurology, University of Bonn, Bonn, Germany.

Subjects: Alzheimer Disease/Alzheimer Disease/Alzheimer Disease/*genetics ; Amyloid beta-Peptides/Amyloid beta-Peptides/Amyloid beta-Peptides/*genetics ; Neurofibrillary Tangles/Neurofibrillary Tangles/Neurofibrillary Tangles/*genetics

  • Source: Molecular medicine (Cambridge, Mass.) [Mol Med] 2015 Oct 27; Vol. 21 Suppl 1, pp. S41-8. Date of Electronic Publication: 2015 Oct 27.Publisher: BioMed Central Country of Publication: England NLM ID: 9501023 Publication Model: Electronic Cited Medium: Internet ISSN: 1528-3658

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Academic Journal

Cytoskeletal alterations differentiate presenilin-1 and sporadic Alzheimer’s disease.

Subjects: ALZHEIMER'S disease; CYTOSKELETAL proteins; PREVENTIVE medicine

  • Source: Acta Neuropathologica; Jan2009, Vol. 117 Issue 1, p19-29, 11p, 3 Diagrams, 3 Charts, 1 Graph

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Academic Journal

Genetics of familial and sporadic Alzheimer's disease.

  • Authors : Piaceri I; Department of Neurological and Psychiatric sciences, University of Florence, Largo Brambilla 3, 50134 Florence, Italy.; Nacmias B

Subjects: Alzheimer Disease/Alzheimer Disease/Alzheimer Disease/*genetics ; Amyloid beta-Protein Precursor/Amyloid beta-Protein Precursor/Amyloid beta-Protein Precursor/*genetics ; Apolipoproteins E/Apolipoproteins E/Apolipoproteins E/*genetics

  • Source: Frontiers in bioscience (Elite edition) [Front Biosci (Elite Ed)] 2013 Jan 01; Vol. 5 (1), pp. 167-77. Date of Electronic Publication: 2013 Jan 01.Publisher: IMR Press Country of Publication: Singapore NLM ID: 101485240 Publication Model: Electronic Cited Medium: Internet ISSN: 1945-0508

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Academic Journal

Aluminum and Neurofibrillary Tangle Co-Localization in Familial Alzheimer's Disease and Related Neurological Disorders.

  • Authors : Mold MJ; The Birchall Centre, Lennard-Jones Laboratories, Keele University, Keele, Staffordshire, UK.; O'Farrell A

Subjects: Aluminum/Aluminum/Aluminum/*metabolism ; Alzheimer Disease/Alzheimer Disease/Alzheimer Disease/*pathology ; Neurofibrillary Tangles/Neurofibrillary Tangles/Neurofibrillary Tangles/*pathology

  • Source: Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2020; Vol. 78 (1), pp. 139-149.Publisher: IOS Press Country of Publication: Netherlands NLM ID: 9814863 Publication Model: Print Cited Medium: Internet ISSN: 1875-8908

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Academic Journal

Changes in proteome solubility indicate widespread proteostatic disruption in mouse models of neurodegenerative disease.

  • Authors : Pace MC; Department of Neuroscience, Center for Translational Research in Neurodegenerative Disease, McKnight Brain Institute, University of Florida, Gainesville, FL, 32610-0244, USA.; Xu G

Subjects: Central Nervous System/Central Nervous System/Central Nervous System/*metabolism ; Central Nervous System/Central Nervous System/Central Nervous System/*pathology ; Neurodegenerative Diseases/Neurodegenerative Diseases/Neurodegenerative Diseases/*pathology

  • Source: Acta neuropathologica [Acta Neuropathol] 2018 Dec; Vol. 136 (6), pp. 919-938. Date of Electronic Publication: 2018 Aug 23.Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0412041 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Aberrant accentuation of neurofibrillary degeneration in the hippocampus of Alzheimer's disease with amyloid precursor protein 717 and presenilin-1 gene mutations.

  • Authors : Sudo S; Department of Neuropsychiatry, Faculty of Medical Sciences, University of Fukui, 23 Shimoaizuki, Matsuoka-cho, Fukui 910-1193, Japan. ; Shiozawa M

Subjects: Alzheimer Disease/Alzheimer Disease/Alzheimer Disease/*genetics ; Amyloid beta-Protein Precursor/Amyloid beta-Protein Precursor/Amyloid beta-Protein Precursor/*genetics ; Hippocampus/Hippocampus/Hippocampus/*pathology

  • Source: Journal of the neurological sciences [J Neurol Sci] 2005 Jul 15; Vol. 234 (1-2), pp. 55-65.Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0375403 Publication Model: Print Cited Medium: Print ISSN: 0022-510X (Print)

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Academic Journal

Increased tau phosphorylation but absence of formation of neurofibrillary tangles in mice double transgenic for human tau and Alzheimer mutant (M146L) presenilin-1.

  • Authors : Boutajangout A; Laboratory of Histology and Neuropathology, Université Libre de Bruxelles, Campus Erasme, 808 Route de Lennik, B-1070, Brussels, Belgium.; Leroy K

Subjects: Trans-Activators*; Membrane Proteins/Membrane Proteins/Membrane Proteins/*genetics ; Neurofibrillary Tangles/Neurofibrillary Tangles/Neurofibrillary Tangles/*pathology

  • Source: Neuroscience letters [Neurosci Lett] 2002 Jan 18; Vol. 318 (1), pp. 29-33.Publisher: Elsevier Scientific Publishers Ireland Country of Publication: Ireland NLM ID: 7600130 Publication Model: Print Cited Medium: Print ISSN:

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Academic Journal

Novel human neuronal tau model exhibiting neurofibrillary tangles and transcellular propagation.

  • Authors : Reilly P; Department of Neurosciences, University of California, San Diego, School of Medicine, La Jolla, CA 92093, United States.; Winston CN

Subjects: Induced Pluripotent Stem Cells/Induced Pluripotent Stem Cells/Induced Pluripotent Stem Cells/*metabolism ; Neurofibrillary Tangles/Neurofibrillary Tangles/Neurofibrillary Tangles/*metabolism ; Tauopathies/Tauopathies/Tauopathies/*metabolism

  • Source: Neurobiology of disease [Neurobiol Dis] 2017 Oct; Vol. 106, pp. 222-234. Date of Electronic Publication: 2017 Jun 10.Publisher: Academic Press Country of Publication: United States NLM ID: 9500169 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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  • 1-10 of  359 results for ""Presenilin-1""