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Academic Journal

BACE inhibitor treatment of mice induces hyperactivity in a Seizure-related gene 6 family dependent manner without altering learning and memory.

  • Authors : Nash A; Department of Anatomy and Physiology, University of Melbourne, Melbourne, VIC, Australia.; Gijsen HJM

Subjects: Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/*antagonists & inhibitors ; Aspartic Acid Endopeptidases/Aspartic Acid Endopeptidases/Aspartic Acid Endopeptidases/*antagonists & inhibitors ; Learning/Learning/Learning/*physiology

  • Source: Scientific reports [Sci Rep] 2021 Jul 23; Vol. 11 (1), pp. 15084. Date of Electronic Publication: 2021 Jul 23.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Drosophila Full-Length Amyloid Precursor Protein Is Required for Visual Working Memory and Prevents Age-Related Memory Impairment.

  • Authors : Rieche F; Institut für Entwicklungsbiologie und Neurobiologie, Johannes Gutenberg-Universität Mainz, Colonel-Kleinmann-Weg 2, 55099 Mainz, Germany.; Carmine-Simmen K

Subjects: Memory, Short-Term*; Aging/Aging/Aging/*genetics ; Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/*genetics

  • Source: Current biology : CB [Curr Biol] 2018 Mar 05; Vol. 28 (5), pp. 817-823.e3. Date of Electronic Publication: 2018 Feb 22.Publisher: Cell Press Country of Publication: England NLM ID: 9107782 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0445

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Academic Journal

Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibition Impairs Synaptic Plasticity via Seizure Protein 6.

  • Authors : Zhu K; German Center for Neurodegenerative Diseases, Munich, Germany; Center for Neuropathology and Prion Research, Munich, Germany

Subjects: Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/*metabolism ; Aspartic Acid Endopeptidases/Aspartic Acid Endopeptidases/Aspartic Acid Endopeptidases/*metabolism ; Dendritic Spines/Dendritic Spines/Dendritic Spines/*metabolism

  • Source: Biological psychiatry [Biol Psychiatry] 2018 Mar 01; Vol. 83 (5), pp. 428-437. Date of Electronic Publication: 2016 Dec 26.Publisher: Elsevier Country of Publication: United States NLM ID: 0213264 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Synaptic Vesicle Protein 2B Negatively Regulates the Amyloidogenic Processing of AβPP as a Novel Interaction Partner of BACE1.

  • Authors : Miyamoto M; Department of Neurology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.; Department of Human Health Science, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Subjects: Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/*metabolism ; Amyloid beta-Protein Precursor/Amyloid beta-Protein Precursor/Amyloid beta-Protein Precursor/*metabolism ; Aspartic Acid Endopeptidases/Aspartic Acid Endopeptidases/Aspartic Acid Endopeptidases/*metabolism

  • Source: Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2020; Vol. 75 (1), pp. 173-185.Publisher: IOS Press Country of Publication: Netherlands NLM ID: 9814863 Publication Model: Print Cited Medium: Internet ISSN: 1875-8908

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Academic Journal

Neogenin, Defined as a GD3-associated Molecule by Enzyme-mediated Activation of Radical Sources, Confers Malignant Properties via Intracytoplasmic Domain in Melanoma Cells.

  • Authors : Kaneko K; From the Department of Biochemistry II, Nagoya University Graduate School of Medicine, Nagoya 466-0065.; Ohkawa Y

Subjects: Gene Expression Regulation, Neoplastic*; Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/*metabolism ; Gangliosides/Gangliosides/Gangliosides/*metabolism

  • Source: The Journal of biological chemistry [J Biol Chem] 2016 Aug 05; Vol. 291 (32), pp. 16630-43. Date of Electronic Publication: 2016 Jun 10.Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication

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Academic Journal

Disrupted-in-Schizophrenia-1 Attenuates Amyloid-β Generation and Cognitive Deficits in APP/PS1 Transgenic Mice by Reduction of β-Site APP-Cleaving Enzyme 1 Levels.

  • Authors : Deng QS; Affiliated Bayi Brain Hospital and Affiliated Beijing Military Hospital of Southern Medical University, Beijing, China.; Dong XY

Subjects: Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/*metabolism ; Amyloid beta-Peptides/Amyloid beta-Peptides/Amyloid beta-Peptides/*metabolism ; Aspartic Acid Endopeptidases/Aspartic Acid Endopeptidases/Aspartic Acid Endopeptidases/*metabolism

  • Source: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology [Neuropsychopharmacology] 2016 Jan; Vol. 41 (2), pp. 440-53. Date of Electronic Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8904907 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

A novel BACE inhibitor NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in APP transgenic mice.

  • Authors : Neumann U; Neuroscience, Novartis Institutes for BioMedical Research (NIBR), Basel, Switzerland. .; Rueeger H

Subjects: Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/*antagonists & inhibitors ; Amyloid beta-Peptides/Amyloid beta-Peptides/Amyloid beta-Peptides/*metabolism ; Aspartic Acid Endopeptidases/Aspartic Acid Endopeptidases/Aspartic Acid Endopeptidases/*antagonists & inhibitors

  • Source: Molecular neurodegeneration [Mol Neurodegener] 2015 Sep 03; Vol. 10, pp. 44. Date of Electronic Publication: 2015 Sep 03.Publisher: BioMed Central Country of Publication: England NLM ID: 101266600 Publication Model: Electronic Cited Medium: Internet ISSN: 1750-1326

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Academic Journal

BACE1-cleavage of Sez6 and Sez6L is elevated in Niemann-Pick type C disease mouse brains.

  • Authors : Causevic M; Laboratory for Neurodegenerative Disease Research, Division of Molecular Medicine, Ruder Boskovic Institute, Zagreb, Croatia.; Dominko K

Subjects: Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/*metabolism ; Aspartic Acid Endopeptidases/Aspartic Acid Endopeptidases/Aspartic Acid Endopeptidases/*metabolism ; Brain/Brain/Brain/*metabolism

  • Source: PloS one [PLoS One] 2018 Jul 06; Vol. 13 (7), pp. e0200344. Date of Electronic Publication: 2018 Jul 06 (Print Publication: 2018).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet

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Academic Journal

Identification of rare RTN3 variants in Alzheimer's disease in Han Chinese.

  • Authors : Zou Y; Institute of Molecular Precision Medicine, Xiangya Hospital, Central South University, Changsha, 410078, Hunan, China.; Center for Medical Genetics, School of Life Sciences, Central South University, Changsha, 410078, China.

Subjects: Alzheimer Disease/Alzheimer Disease/Alzheimer Disease/*genetics ; Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/*genetics ; Amyloid beta-Peptides/Amyloid beta-Peptides/Amyloid beta-Peptides/*genetics

  • Source: Human genetics [Hum Genet] 2018 Feb; Vol. 137 (2), pp. 141-150. Date of Electronic Publication: 2018 Jan 22.Publisher: Springer Verlag Country of Publication: Germany NLM ID: 7613873 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Metallothionein-III increases ADAM10 activity in association with furin, PC7, and PKCα during non-amyloidogenic processing.

  • Authors : Park BH; Department of Toxicology, College of Pharmacy, Chungnam National University, Daejeon, Republic of Korea.; Kim HG

Subjects: ADAM Proteins/ADAM Proteins/ADAM Proteins/*metabolism ; Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/*metabolism ; Amyloid beta-Protein Precursor/Amyloid beta-Protein Precursor/Amyloid beta-Protein Precursor/*metabolism

  • Source: FEBS letters [FEBS Lett] 2014 Jun 27; Vol. 588 (14), pp. 2294-300. Date of Electronic Publication: 2014 May 21.Publisher: John Wiley & Sons Ltd Country of Publication: England NLM ID: 0155157 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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  • 1-10 of  164 results for ""Amyloid Precursor Protein Secretases""