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Academic Journal

Novel insights into gut health: Cilostazol strengthens gut integrity by adjusting TLR-2/NF-κB/IL-23 and CD44/AKT/GSK-3β/cyclin-D1 trajectories in methotrexate-induced mucositis model.

  • Authors : Mansour SM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt; Department of Pharmacology, Toxicology and Biochemistry, Faculty of Pharmacy, Future University in Egypt, Cairo, 84518, Egypt. Electronic address: .

Subjects: Rats, Wistar* ; Glycogen Synthase Kinase 3 beta*/Glycogen Synthase Kinase 3 beta*/Glycogen Synthase Kinase 3 beta*/metabolism ; NF-kappa B*/NF-kappa B*/NF-kappa B*/metabolism

  • Source: European journal of pharmacology [Eur J Pharmacol] 2024 Jul 15; Vol. 975, pp. 176669. Date of Electronic Publication: 2024 May 23.Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Therapeutic effect and mechanism of Daikenchuto in a model of methotrexate-induced acute small intestinal mucositis.

  • Authors : Li P; Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.; Department of Surgery, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong, China.

Subjects: Mucositis*/Mucositis*/Mucositis*/chemically induced ; Mucositis*/Mucositis*/Mucositis*/drug therapy ; Mucositis*/Mucositis*/Mucositis*/pathology

  • Source: PloS one [PLoS One] 2023 Mar 30; Vol. 18 (3), pp. e0283626. Date of Electronic Publication: 2023 Mar 30 (Print Publication: 2023).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet

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Academic Journal

Experimental Chemotherapy-Induced Mucositis: A Scoping Review Guiding the Design of Suitable Preclinical Models.

  • Authors : Huang J; Melbourne Dental School, The University of Melbourne, Carlton, VIC 3053, Australia.; Hwang AYM

Subjects: Mucositis*/Mucositis*/Mucositis*/chemically induced ; Mucositis*/Mucositis*/Mucositis*/drug therapy ; Antineoplastic Agents*/Antineoplastic Agents*/Antineoplastic Agents*/toxicity

  • Source: International journal of molecular sciences [Int J Mol Sci] 2022 Dec 06; Vol. 23 (23). Date of Electronic Publication: 2022 Dec 06.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

Evaluation and validation of chemotherapy-specific diarrhoea and histopathology in rats.

  • Authors : Dahlgren D; Department of Pharmaceutical Biosciences, Translational Drug Discovery and Development, Uppsala University, Uppsala, Sweden.; Rosenqvist E

Subjects: Mucositis*/Mucositis*/Mucositis*/chemically induced ; Mucositis*/Mucositis*/Mucositis*/drug therapy ; Mucositis*/Mucositis*/Mucositis*/pathology

  • Source: Basic & clinical pharmacology & toxicology [Basic Clin Pharmacol Toxicol] 2022 Dec; Vol. 131 (6), pp. 536-546. Date of Electronic Publication: 2022 Sep 30.Publisher: Blackwell Country of Publication: England NLM ID: 101208422 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1742-7843

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Academic Journal

Development of a self-limiting model of methotrexate-induced mucositis reinforces butyrate as a potential therapy.

  • Authors : da Silva Ferreira AR; Department of Medical Microbiology and Infection prevention, University of Groningen, University Medical Center Groningen, Hanzeplein 1 EB80, 9713 GZ, Groningen, The Netherlands.; Research Centre for Healthy and Sustainable Living, Innovative Testing in Life Sciences and Chemistry, University of Applied Sciences, Utrecht, The Netherlands.

Subjects: Antimetabolites, Antineoplastic/Antimetabolites, Antineoplastic/Antimetabolites, Antineoplastic/*toxicity ; Butyrates/Butyrates/Butyrates/*pharmacology ; Ileum/Ileum/Ileum/*drug effects

  • Source: Scientific reports [Sci Rep] 2021 Nov 25; Vol. 11 (1), pp. 22911. Date of Electronic Publication: 2021 Nov 25.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

The Mechanisms of the Anti-Inflammatory and Anti-Apoptotic Effects of Omega-3 Polyunsaturated Fatty Acids during Methotrexate-Induced Intestinal Damage in Cell Line and in a Rat Model.

  • Authors : Koppelmann T; Laboratory of Intestinal Adaptation and Recovery, Department of Paediatric Surgery, Dana-Dwek Children's Hospital, Tel Aviv Sourasky Medical Center, 6 Weizmann st, Tel Aviv 6423906, Israel.; Pollak Y

Subjects: Anti-Inflammatory Agents/Anti-Inflammatory Agents/Anti-Inflammatory Agents/*administration & dosage ; Apoptosis/Apoptosis/Apoptosis/*drug effects ; Cytokines/Cytokines/Cytokines/*metabolism

  • Source: Nutrients [Nutrients] 2021 Mar 10; Vol. 13 (3). Date of Electronic Publication: 2021 Mar 10.Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Pre-therapy fasting slows epithelial turnover and modulates the microbiota but fails to mitigate methotrexate-induced gastrointestinal mucositis.

  • Authors : Wardill HR; Adelaide Medical School, The University of Adelaide , Adelaide, Australia.; Department of Pediatrics, University Medical Centre Groningen, The University of Groningen , Groningen, The Netherlands.

Subjects: Fasting*; Methotrexate/Methotrexate/Methotrexate/*toxicity ; Mucositis/Mucositis/Mucositis/*chemically induced

  • Source: Gut microbes [Gut Microbes] 2020 Nov 09; Vol. 12 (1), pp. 1-9.Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101495343 Publication Model: Print Cited Medium: Internet ISSN:

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Academic Journal

Orally administered salecan ameliorates methotrexate-induced intestinal mucositis in mice.

  • Authors : Gao Y; Center for Molecular Metabolism, Nanjing University of Science and Technology, 200 Xiaolingwei, Nanjing, 210094, Jiangsu, People's Republic of China.; Sun Q

Subjects: Antimetabolites, Antineoplastic/Antimetabolites, Antineoplastic/Antimetabolites, Antineoplastic/*toxicity ; Antioxidants/Antioxidants/Antioxidants/*pharmacology ; Methotrexate/Methotrexate/Methotrexate/*toxicity

  • Source: Cancer chemotherapy and pharmacology [Cancer Chemother Pharmacol] 2019 Jul; Vol. 84 (1), pp. 105-116. Date of Electronic Publication: 2019 May 08.Publisher: Springer Verlag Country of Publication: Germany NLM ID: 7806519 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Zinc Supplementation Alone Is Effective for Partial Amelioration of Methotrexate-induced Intestinal Damage.

Subjects: Intestinal Mucosa/Intestinal Mucosa/Intestinal Mucosa/*drug effects ; Intestine, Small/Intestine, Small/Intestine, Small/*drug effects ; Methotrexate/Methotrexate/Methotrexate/*toxicity

  • Source: Alternative therapies in health and medicine [Altern Ther Health Med] 2015; Vol. 21 Suppl 2, pp. 22-31.Publisher: InnoVision Communications Country of Publication: United States NLM ID: 9502013 Publication Model: Print Cited Medium: Print ISSN:

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Academic Journal

Olmesartan decreased levels of IL-1β and TNF-α, down-regulated MMP-2, MMP-9, COX-2, RANK/RANKL and up-regulated SOCs-1 in an intestinal mucositis model.

  • Authors : de Araújo RF Jr; Post graduation program Health Science/Department of Morphology, UFRN, Natal, RN, Brazil; Post graduation program in Functional and Structural Biology/UFRN, Natal, RN, Brazil

Subjects: Angiotensin II Type 1 Receptor Blockers/Angiotensin II Type 1 Receptor Blockers/Angiotensin II Type 1 Receptor Blockers/*pharmacology ; Cytokines/Cytokines/Cytokines/*metabolism ; Down-Regulation/Down-Regulation/Down-Regulation/*drug effects

  • Source: PloS one [PLoS One] 2014 Dec 22; Vol. 9 (12), pp. e114923. Date of Electronic Publication: 2014 Dec 22 (Print Publication: 2014).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet

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  • 1-10 of  35 results for ""Methotrexate toxicity""