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Enhanced translocation of TRIM32 to mitochondria sensitizes dopaminergic neuronal cells to apoptosis during stress conditions in Parkinson's disease.

• Authors : Goyani S; Department of Biochemistry, Faculty of Science, The M.S. University of Baroda, Vadodara, India.; Shinde A

Subjects: Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/metabolism ; Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/genetics ; Mitochondria*/Mitochondria*/Mitochondria*/metabolism

• Source: The FEBS journal [FEBS J] 2024 Jun; Vol. 291 (12), pp. 2636-2655. Date of Electronic Publication: 2024 Feb 05.Publisher: Published by Blackwell Pub. on behalf of the Federation of European Biochemical Societies Country of Publication: England NLM ID: 101229646 Publication

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Genome-wide and functional annotation of human E3 ubiquitin ligases identifies MULAN, a mitochondrial E3 that regulates the organelle's dynamics and signaling.

• Authors : Li W; Department of Cell Biology, The Scripps Research Institute, La Jolla, California, USA.; Bengtson MH

Subjects: Genome, Human* ; Signal Transduction*; Mitochondria/Mitochondria/Mitochondria/*enzymology

• Source: PloS one [PLoS One] 2008 Jan 23; Vol. 3 (1), pp. e1487. Date of Electronic Publication: 2008 Jan 23.Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: Electronic Cited Medium: Internet

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Role of the Mitochondrial E3 Ubiquitin Ligases as Possible Therapeutic Targets in Cancer Therapy.

• Authors : Di Gregorio, Jacopo; Appignani, Martina; Flati, Vincenzo

Subjects: UBIQUITINATION; UBIQUITIN-conjugating enzymes; CANCER treatment

• Source: International Journal of Molecular Sciences; Dec2023, Vol. 24 Issue 24, p17176, 14p

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Education Full Text (H.W. Wilson)

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Mitochondrial MUL1 E3 ubiquitin ligase regulates Hypoxia Inducible Factor (HIF-1α) and metabolic reprogramming by modulating the UBXN7 cofactor protein.

• Authors : Cilenti L; Burnett School of Biomedical Sciences, University of Central Florida College of Medicine, 12722, Research Parkway Orlando, FL, 32826, USA.; Di Gregorio J

Subjects: Adaptor Proteins, Signal Transducing/Adaptor Proteins, Signal Transducing/Adaptor Proteins, Signal Transducing/*metabolism ; Hypoxia/Hypoxia/Hypoxia/*metabolism ; Hypoxia-Inducible Factor 1, alpha Subunit/Hypoxia-Inducible Factor 1, alpha Subunit/Hypoxia-Inducible Factor 1, alpha Subunit/*metabolism

• Source: Scientific reports [Sci Rep] 2020 Jan 31; Vol. 10 (1), pp. 1609. Date of Electronic Publication: 2020 Jan 31.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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E3 Ligases Regulate Organelle Inheritance in Yeast.

• Authors : Obara, Keisuke¹ (AUTHOR) ; Nishimura, Kohei¹ (AUTHOR); Kamura, Takumi¹ (AUTHOR)

Subjects: *LIGASES; *UBIQUITIN ligases; *ADAPTOR proteins

• Source: Cells (2073-4409). Feb2024, Vol. 13 Issue 4, p292. 10p.

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SS-31 mitigates oxidative stress and restores mitochondrial function in cigarette smoke-damaged oral epithelial cells via PINK1-mediated mitophagy.

• Authors : Ye P; Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Research Institute of Stomatology, Nanjing University, Nanjing, China.; Liu H

Subjects: Oxidative Stress*/Oxidative Stress*/Oxidative Stress*/drug effects ; Mitophagy*/Mitophagy*/Mitophagy*/drug effects ; Mitochondria*/Mitochondria*/Mitochondria*/drug effects

• Source: Chemico-biological interactions [Chem Biol Interact] 2024 Sep 01; Vol. 400, pp. 111166. Date of Electronic Publication: 2024 Jul 26.Publisher: Elsevier Country of Publication: Ireland NLM ID: 0227276 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7786

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Repeated Silica exposures lead to Silicosis severity via PINK1/PARKIN mediated mitochondrial dysfunction in mice model.

• Authors : Kumari S; Department of Zoology, MMV, Banaras Hindu University, Varanasi 221005, India.; Singh P

Subjects: Mitochondria*/Mitochondria*/Mitochondria*/metabolism ; Mitochondria*/Mitochondria*/Mitochondria*/drug effects ; Protein Kinases*/Protein Kinases*/Protein Kinases*/metabolism

• Source: Cellular signalling [Cell Signal] 2024 Sep; Vol. 121, pp. 111272. Date of Electronic Publication: 2024 Jun 27.Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 8904683 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Suppressed basal mitophagy drives cellular aging phenotypes that can be reversed by a p62-targeting small molecule.

• Authors : Kelly G; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE4 5PL, UK.; Kataura T

Subjects: Mitophagy*/Mitophagy*/Mitophagy*/drug effects ; Cellular Senescence*/Cellular Senescence*/Cellular Senescence*/drug effects ; Mitochondria*/Mitochondria*/Mitochondria*/metabolism

• Source: Developmental cell [Dev Cell] 2024 Aug 05; Vol. 59 (15), pp. 1924-1939.e7. Date of Electronic Publication: 2024 Jun 18.Publisher: Cell Press Country of Publication: United States NLM ID: 101120028 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Deciphering the neuroprotective mechanisms of RACK1 in cerebral ischemia-reperfusion injury: Pioneering insights into mitochondrial autophagy and the PINK1/Parkin axis.

• Authors : Zhao L; Department of Sleep Medicine Center, The Shengjing Affiliated Hospital, China Medical University, Shenyang, Liaoning, People's Republic of China.; Chen Y

Subjects: Autophagy*/Autophagy*/Autophagy*/physiology ; Mitochondria*/Mitochondria*/Mitochondria*/metabolism ; Protein Kinases*/Protein Kinases*/Protein Kinases*/metabolism

• Source: CNS neuroscience & therapeutics [CNS Neurosci Ther] 2024 Aug; Vol. 30 (8), pp. e14836.Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101473265 Publication Model: Print Cited Medium: Internet ISSN: 1755-5949

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