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Academic Journal

Nephroprotective Potential of 1,3,4-Oxadiazole Derivative Against Methotrexate-Induced Nephrotoxicity in Rats by Upregulating Nrf2 and Downregulating NF-κB and TNF-α Signaling Pathways.

  • Authors : Rafique Z; Department of Pharmacy,Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.; Aabid M

Subjects: Methotrexate*/Methotrexate*/Methotrexate*/toxicity ; Methotrexate*/Methotrexate*/Methotrexate*/adverse effects ; NF-E2-Related Factor 2*/NF-E2-Related Factor 2*/NF-E2-Related Factor 2*/metabolism

  • Source: Journal of biochemical and molecular toxicology [J Biochem Mol Toxicol] 2024 Dec; Vol. 38 (12), pp. e70084.Publisher: Wiley Country of Publication: United States NLM ID: 9717231 Publication Model: Print Cited Medium: Internet ISSN: 1099-0461

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Taurine and enzymatically modified isoquercitrin protected against methotrexate-induced deteriorations in the conductivity and rhythmicity of the heart in rats: Antioxidant, anti-inflammatory, and histological architecture approach.

  • Authors : Mahmoud MM; Department of Zoology, Faculty of Science, Ain Shams University, Cairo, Egypt.; El-Batran SA

Subjects: Quercetin*/Quercetin*/Quercetin*/pharmacology ; Quercetin*/Quercetin*/Quercetin*/analogs & derivatives ; Methotrexate*/Methotrexate*/Methotrexate*/toxicity

  • Source: Journal of applied toxicology : JAT [J Appl Toxicol] 2024 Dec; Vol. 44 (12), pp. 1924-1935. Date of Electronic Publication: 2024 Aug 12.Publisher: John Wiley And Sons Country of Publication: England NLM ID: 8109495 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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STING signaling contributes to methotrexate-induced liver injury by regulating ferroptosis in mice.

  • Authors : Wang HF; Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. Electronic address: .; He YQ

Subjects: Ferroptosis*/Ferroptosis*/Ferroptosis*/drug effects ; Methotrexate*/Methotrexate*/Methotrexate*/toxicity ; Mice, Inbred C57BL*

  • Source: Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2024 Nov 15; Vol. 287, pp. 117306. Date of Electronic Publication: 2024 Nov 14.Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7805381 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Molecular mechanisms underlying methotrexate-induced intestinal injury and protective strategies.

  • Authors : Ali GF; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Beni-Suef University, Beni Suef, 62514, Egypt.; Hassanein EHM

Subjects: Methotrexate*/Methotrexate*/Methotrexate*/toxicity ; Methotrexate*/Methotrexate*/Methotrexate*/adverse effects; Humans

  • Source: Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2024 Nov; Vol. 397 (11), pp. 8165-8188. Date of Electronic Publication: 2024 Jun 01.Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0326264 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Vinpocetine attenuates methotrexate-induced hippocampal intoxication via Keap-1/Nrf2, NF-κB/AP-1, and apoptotic pathways in rats.

  • Authors : Alghamdi B; Department of Physiology, Neuroscience Unit, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.; Neuroscience and Geroscience Research Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.

Subjects: Methotrexate*/Methotrexate*/Methotrexate*/toxicity ; Apoptosis*/Apoptosis*/Apoptosis*/drug effects ; Vinca Alkaloids*/Vinca Alkaloids*/Vinca Alkaloids*/pharmacology

  • Source: Drug and chemical toxicology [Drug Chem Toxicol] 2024 Nov; Vol. 47 (6), pp. 1038-1049. Date of Electronic Publication: 2024 Mar 20.Publisher: Taylor & Francis Group Country of Publication: United States NLM ID: 7801723 Publication Model: Print-Electronic Cited Medium: Internet

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Morinda officinalis iridoid glycosides alleviate methotrexate-induced liver injury in CIA rats by increasing liver autophagy and improving lipid metabolism homeostasis.

  • Authors : Zhu L; School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, 310053, China; Department of Pharmacy, Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou, 310006, China.

Subjects: Methotrexate*/Methotrexate*/Methotrexate*/toxicity ; Morinda*/Morinda*/Morinda*/chemistry ; Lipid Metabolism*/Lipid Metabolism*/Lipid Metabolism*/drug effects

  • Source: Journal of ethnopharmacology [J Ethnopharmacol] 2024 Oct 28; Vol. 333, pp. 118486. Date of Electronic Publication: 2024 Jun 22.Publisher: Elsevier Sequoia Country of Publication: Ireland NLM ID: 7903310 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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A European consensus recommendation on the management of delayed methotrexate elimination: supportive measures, leucovorin rescue and glucarpidase treatment.

  • Authors : Bielack SS; Paediatrics 5 (Oncology, Haematology, Immunology), Klinikum Stuttgart - Olgahospital, Stuttgart Cancer Centre, Stuttgart, Germany.; Soussain C

Subjects: Methotrexate*/Methotrexate*/Methotrexate*/therapeutic use ; Methotrexate*/Methotrexate*/Methotrexate*/administration & dosage ; Methotrexate*/Methotrexate*/Methotrexate*/adverse effects

  • Source: Journal of cancer research and clinical oncology [J Cancer Res Clin Oncol] 2024 Oct 02; Vol. 150 (10), pp. 441. Date of Electronic Publication: 2024 Oct 02.Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 7902060 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-1335

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Evaluation the effects of Omega-3 and vitamin C alone or in combination on Methotrexate-Induced hepatotoxicity (in mice).

Subjects: Methotrexate*/Methotrexate*/Methotrexate*/toxicity ; Methotrexate*/Methotrexate*/Methotrexate*/adverse effects ; Ascorbic Acid*/Ascorbic Acid*/Ascorbic Acid*/pharmacology

  • Source: JPMA. The Journal of the Pakistan Medical Association [J Pak Med Assoc] 2024 Oct; Vol. 74 (10 (Supple-8)), pp. S414-S418.Publisher: Pakistan Medical Association Country of Publication: Pakistan NLM ID: 7501162 Publication Model: Print Cited Medium: Internet ISSN:

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Evaluation of concurrent use of Vitamin C and Niclosamide against methotrexate-induced liver injury in mice.

Subjects: Ascorbic Acid*/Ascorbic Acid*/Ascorbic Acid*/pharmacology ; Ascorbic Acid*/Ascorbic Acid*/Ascorbic Acid*/therapeutic use ; Methotrexate*/Methotrexate*/Methotrexate*/toxicity

  • Source: JPMA. The Journal of the Pakistan Medical Association [J Pak Med Assoc] 2024 Oct; Vol. 74 (10 (Supple-8)), pp. S419-S424.Publisher: Pakistan Medical Association Country of Publication: Pakistan NLM ID: 7501162 Publication Model: Print Cited Medium: Internet ISSN:

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Evaluation of the hepatoprotective effect of curcumin alone or in combination with vitamin C in methotrexate-induced hepatotoxicity in mice.

  • Authors : Khudair DH; Department of Clinical Pharmacology and Therapeutics, Mustansiriyah University, Baghdad, Iraq.; Al-Gareeb AI

Subjects: Curcumin*/Curcumin*/Curcumin*/pharmacology ; Methotrexate*/Methotrexate*/Methotrexate*/toxicity ; Ascorbic Acid*/Ascorbic Acid*/Ascorbic Acid*/pharmacology

  • Source: JPMA. The Journal of the Pakistan Medical Association [J Pak Med Assoc] 2024 Oct; Vol. 74 (10 (Supple-8)), pp. S442-S446.Publisher: Pakistan Medical Association Country of Publication: Pakistan NLM ID: 7501162 Publication Model: Print Cited Medium: Internet ISSN:

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  • 1-10 of  959 results for ""Methotrexate toxicity""