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Academic Journal

A sterol analog inhibits hedgehog pathway by blocking cholesterylation of smoothened.

  • Authors : Liu YB; Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Taikang Center for Life and Medical Sciences, Wuhan University, Wuhan 430000, China.; He LM

Subjects: Smoothened Receptor*/Smoothened Receptor*/Smoothened Receptor*/antagonists & inhibitors ; Smoothened Receptor*/Smoothened Receptor*/Smoothened Receptor*/metabolism ; Hedgehog Proteins*/Hedgehog Proteins*/Hedgehog Proteins*/metabolism

  • Source: Cell chemical biology [Cell Chem Biol] 2024 Jul 18; Vol. 31 (7), pp. 1264-1276.e7. Date of Electronic Publication: 2024 Mar 04.Publisher: Cell Press Country of Publication: United States NLM ID: 101676030 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Nilotinib, an approved leukemia drug, inhibits smoothened signaling in Hedgehog-dependent medulloblastoma.

  • Authors : Chahal KK; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego (UCSD), La Jolla, California, United States of America.; Department of Pharmaceutical Sciences, G.J. University of Science and Technology, Hisar, India.

Subjects: Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*pharmacology ; Medulloblastoma/Medulloblastoma/Medulloblastoma/*drug therapy ; Pyrimidines/Pyrimidines/Pyrimidines/*pharmacology

  • Source: PloS one [PLoS One] 2019 Sep 20; Vol. 14 (9), pp. e0214901. Date of Electronic Publication: 2019 Sep 20 (Print Publication: 2019).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet

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Academic Journal

Truncated BRPF1 Cooperates with Smoothened to Promote Adult Shh Medulloblastoma.

  • Authors : Aiello G; Armenise-Harvard Laboratory of Brain Disorders and Cancer, CIBIO, University of Trento, Via Sommarive 9, 38123 Trento, Italy.; Ballabio C

Subjects: Mutation*; Adaptor Proteins, Signal Transducing/Adaptor Proteins, Signal Transducing/Adaptor Proteins, Signal Transducing/*metabolism ; Cerebellar Neoplasms/Cerebellar Neoplasms/Cerebellar Neoplasms/*pathology

  • Source: Cell reports [Cell Rep] 2019 Dec 17; Vol. 29 (12), pp. 4036-4052.e10.Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print Cited Medium: Internet ISSN: 2211-1247

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Academic Journal

A CK1α Activator Penetrates the Brain and Shows Efficacy Against Drug-resistant Metastatic Medulloblastoma.

  • Authors : Rodriguez-Blanco J; Molecular Oncology Program, The DeWitt Daughtry Family Department of Surgery, University of Miami, Miller School of Medicine, Miami, Florida.; Li B

Subjects: Benzoates/Benzoates/Benzoates/*pharmacology ; Casein Kinase Ialpha/Casein Kinase Ialpha/Casein Kinase Ialpha/*genetics ; Medulloblastoma/Medulloblastoma/Medulloblastoma/*drug therapy

  • Source: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2019 Feb 15; Vol. 25 (4), pp. 1379-1388. Date of Electronic Publisher: The Association Country of Publication: United States NLM ID: 9502500 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Steroidal alkaloids isolated from Veratrum grandiflorum Loes. as novel Smoothened inhibitors with anti-proliferation effects on DAOY medulloblastoma cells.

  • Authors : Gao LJ; Key Laboratory of Neuropsychiatric Drug Research of Zhejiang Province, Institute of Materia Medica, Hangzhou Medical College, Hangzhou, Zhejiang 310013, China.; Zhang MZ

Subjects: Alkaloids/Alkaloids/Alkaloids/*isolation & purification ; Alkaloids/Alkaloids/Alkaloids/*pharmacology ; Cell Proliferation/Cell Proliferation/Cell Proliferation/*drug effects

  • Source: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2021 Jun 01; Vol. 39, pp. 116166. Date of Electronic Publication: 2021 Apr 21.Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Inhibition of the FACT Complex Targets Aberrant Hedgehog Signaling and Overcomes Resistance to Smoothened Antagonists.

  • Authors : Mo J; Research Center of Translational Medicine, Shanghai Children's Hospital, State Key Laboratory of Oncogenes and Related Genes, Key Laboratory of Cell Differentiation and Apoptosis of National Ministry of Education, Department of Pathophysiology, Shanghai Jiao Tong University School of Medicine, Shanghai, P.R. China.; Liu F

Subjects: Drug Resistance, Neoplasm*; Carbazoles/Carbazoles/Carbazoles/*pharmacology ; DNA-Binding Proteins/DNA-Binding Proteins/DNA-Binding Proteins/*antagonists & inhibitors

  • Source: Cancer research [Cancer Res] 2021 Jun 01; Vol. 81 (11), pp. 3105-3120. Date of Electronic Publication: 2021 Apr 14.Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print-Electronic Cited Medium:

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Academic Journal

Lateral cerebellum is preferentially sensitive to high sonic hedgehog signaling and medulloblastoma formation.

  • Authors : Tan IL; Developmental Biology Program, Sloan Kettering Institute, New York, NY 10065.; Biochemistry, Cell, and Molecular Biology Program, Weill Graduate School of Medical Sciences of Cornell University, New York, NY 10065.

Subjects: Cerebellar Neoplasms/Cerebellar Neoplasms/Cerebellar Neoplasms/*pathology ; Cerebellum/Cerebellum/Cerebellum/*pathology ; Hedgehog Proteins/Hedgehog Proteins/Hedgehog Proteins/*metabolism

  • Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2018 Mar 27; Vol. 115 (13), pp. 3392-3397. Date of Electronic Publication: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Smoothened-activating lipids drive resistance to CDK4/6 inhibition in Hedgehog-associated medulloblastoma cells and preclinical models.

  • Authors : Daggubati V; Department of Radiation Oncology.; Department of Neurological Surgery.

Subjects: Cerebellar Neoplasms/Cerebellar Neoplasms/Cerebellar Neoplasms/*metabolism ; Cyclin-Dependent Kinase 4/Cyclin-Dependent Kinase 4/Cyclin-Dependent Kinase 4/*antagonists & inhibitors ; Cyclin-Dependent Kinase 6/Cyclin-Dependent Kinase 6/Cyclin-Dependent Kinase 6/*antagonists & inhibitors

  • Source: The Journal of clinical investigation [J Clin Invest] 2021 Mar 15; Vol. 131 (6).Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: Print Cited Medium:

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Report

Occurrence and characterization of medulloblastoma in a patient with Curry-Jones syndrome.

  • Authors : Porath B; Department of Pathology and Laboratory Medicine, Children's Mercy Hospital, Kansas City, Missouri.; Farooki S

Subjects: Genetic Predisposition to Disease*; Craniofacial Abnormalities/Craniofacial Abnormalities/Craniofacial Abnormalities/*diagnosis ; Intestines/Intestines/Intestines/*abnormalities Winter Shortland Temple syndrome

  • Source: Clinical genetics [Clin Genet] 2020 Apr; Vol. 97 (4), pp. 670-671. Date of Electronic Publication: 2019 Dec 11.Publisher: Munksgaard Country of Publication: Denmark NLM ID: 0253664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1399-0004

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Academic Journal

Upregulation of apoptotic genes and downregulation of target genes of Sonic Hedgehog signaling pathway in DAOY medulloblastoma cell line treated with arsenic trioxide.

  • Authors : Ghorbanlou M; Department of Anatomy, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.; Moradi F

Subjects: Arsenic Trioxide*/Arsenic Trioxide*/Arsenic Trioxide*/pharmacology ; Medulloblastoma*/Medulloblastoma*/Medulloblastoma*/drug therapy ; Medulloblastoma*/Medulloblastoma*/Medulloblastoma*/genetics

  • Source: Journal of chemotherapy (Florence, Italy) [J Chemother] 2024 Oct; Vol. 36 (6), pp. 506-519. Date of Electronic Publication: 2023 Dec 22.Publisher: Taylor & Francis Country of Publication: England NLM ID: 8907348 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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  • 1-10 of  73 results for ""Smoothened Receptor""