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Academic Journal

Utility of Chimeric Mice with Humanized Livers for Predicting Hepatic Organic Anion-Transporting Polypeptide 1B-Mediated Clinical Drug-Drug Interactions.

  • Authors : Feng B; Drug Metabolism and Pharmacokinetics, Vertex Pharmaceuticals, Boston, Massachusetts (B.F., G.L., C.Z., S.L., H.H., J.W., H.G., S.K.) and PhoenixBio USA Corporation, New York, New York (Y.M.) .; Liang G

Subjects: Drug Interactions* ; Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/metabolism ; Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/antagonists & inhibitors

  • Source: Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2024 Sep 16; Vol. 52 (10), pp. 1073-1082. Date of Electronic Publication: 2024 Sep 16.Publisher: American Society for Pharmacology and Experimental Therapeutics, etc.] Country of Publication: United States NLM ID: 9421550 Publication Model:

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Academic Journal

Systematic Evaluation of Tyrosine Kinase Inhibitors as OATP1B1 Substrates Using a Competitive Counterflow Screen.

  • Authors : Drabison T; Division of Pharmaceutics and Pharmacology, College of Pharmacy, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio.; Boeckman M

Subjects: Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/metabolism ; Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/antagonists & inhibitors ; Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/genetics

  • Source: Cancer research communications [Cancer Res Commun] 2024 Sep 01; Vol. 4 (9), pp. 2489-2497.Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 9918281580506676 Publication Model: Print Cited Medium:

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Academic Journal

Interaction of myricetin, ampelopsin (dihydromyricetin), and their sulfate metabolites with serum albumin, cytochrome P450 (CYP2C9, 2C19, and 3A4) enzymes, and organic anion-transporting polypeptides (OATP1B1 and OATP2B1).

  • Authors : Dombi Á; Department of Pharmacology, Faculty of Pharmacy, University of Pécs, Pécs, Hungary.; Kaci H

Subjects: Flavonoids*/Flavonoids*/Flavonoids*/pharmacology ; Organic Anion Transporters*/Organic Anion Transporters*/Organic Anion Transporters*/metabolism ; Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/metabolism

  • Source: Pharmacology research & perspectives [Pharmacol Res Perspect] 2024 Oct; Vol. 12 (5), pp. e70021.Publisher: John Wiley & Sons Ltd, British Pharmacological Society and American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States

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Academic Journal

Identification of reversible OATP1B1 and time-dependent CYP3A4 inhibition as the major risk factors for drug-induced cholestasis (DIC).

  • Authors : Kastrinou-Lampou V; Pharmacokinetic Sciences, BioMedical Research, Novartis, Basel, Switzerland.; Preclinical Safety, BioMedical Research, Novartis, Basel, Switzerland.

Subjects: Cholestasis*/Cholestasis*/Cholestasis*/chemically induced ; Cholestasis*/Cholestasis*/Cholestasis*/metabolism ; Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/metabolism

  • Source: Archives of toxicology [Arch Toxicol] 2024 Oct; Vol. 98 (10), pp. 3409-3424. Date of Electronic Publication: 2024 Jul 18.Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417615 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Human organic anion transporting polypeptide 1B3 (OATP1B3) is more heavily N-glycosylated than OATP1B1 in extracellular loops 2 and 5.

  • Authors : Liang T; College of Pharmaceutical Sciences, Soochow University, 199 Renai Road, Suzhou Industrial Park, Suzhou, Jiangsu 215123, China.; Liu H

Subjects: Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/metabolism ; Solute Carrier Organic Anion Transporter Family Member 1B3*/Solute Carrier Organic Anion Transporter Family Member 1B3*/Solute Carrier Organic Anion Transporter Family Member 1B3*/metabolism ; Solute Carrier Organic Anion Transporter Family Member 1B3*/Solute Carrier Organic Anion Transporter Family Member 1B3*/Solute Carrier Organic Anion Transporter Family Member 1B3*/genetics

  • Source: International journal of biological macromolecules [Int J Biol Macromol] 2024 Oct; Vol. 278 (Pt 2), pp. 134748. Date of Electronic Publication: 2024 Aug 13.Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

SLCO1B1 and ABCG2 genotype-informed phenotypes are related to variation in ramipril exposure.

  • Authors : Abbes H; Clinical Pharmacology Department, Hospital Universitario de La Princesa, Universidad Autónoma de Madrid (UAM), Instituto de Investigación Sanitaria La Princesa (IP), Madrid, Spain.; Biochemistry Department, LR12SP11, Sahloul University Hospital, Sousse, Tunisia.

Subjects: ATP Binding Cassette Transporter, Subfamily G, Member 2*/ATP Binding Cassette Transporter, Subfamily G, Member 2*/ATP Binding Cassette Transporter, Subfamily G, Member 2*/genetics ; ATP Binding Cassette Transporter, Subfamily G, Member 2*/ATP Binding Cassette Transporter, Subfamily G, Member 2*/ATP Binding Cassette Transporter, Subfamily G, Member 2*/metabolism ; Ramipril*/Ramipril*/Ramipril*/pharmacokinetics

  • Source: Basic & clinical pharmacology & toxicology [Basic Clin Pharmacol Toxicol] 2024 Sep; Vol. 135 (3), pp. 295-307. Date of Electronic Publication: 2024 Jul 16.Publisher: Blackwell Country of Publication: England NLM ID: 101208422 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1742-7843

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Academic Journal

The reduced function allele SLCO1B1 c.521T>C is of no practical relevance for the renal graft function over the first post-transplant year in patients treated with mycophenolic acid.

Subjects: Kidney Transplantation*/Kidney Transplantation*/Kidney Transplantation*/adverse effects ; Mycophenolic Acid*/Mycophenolic Acid*/Mycophenolic Acid*/adverse effects ; Mycophenolic Acid*/Mycophenolic Acid*/Mycophenolic Acid*/administration & dosage

  • Source: Pharmacogenetics and genomics [Pharmacogenet Genomics] 2024 Sep 01; Vol. 34 (7), pp. 226-235. Date of Electronic Publication: 2024 May 20.Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 101231005 Publication Model: Print-Electronic Cited Medium:

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Academic Journal

Physiologically Based Pharmacokinetic Model of OATP1B Substrates with a Nonlinear Mixed Effect Approach: Estimating Empirical In Vitro-to-In Vivo Scaling Factors.

  • Authors : Li R; Pharmacokinetics Dynamics and Metabolism, Pfizer Global Research and Development, Cambridge, MA, 02139, USA. .; Kimoto E

Subjects: Models, Biological* ; Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/metabolism ; Nonlinear Dynamics*

  • Source: Clinical pharmacokinetics [Clin Pharmacokinet] 2024 Aug; Vol. 63 (8), pp. 1177-1189. Date of Electronic Publication: 2024 Aug 19.Publisher: Country of Publication: Switzerland NLM ID: 7606849 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1179-1926

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Academic Journal

Mechanistic Account of Distinct Change in Organic Anion Transporting Polypeptide 1B (OATP1B) Substrate Pharmacokinetics during OATP1B-Mediated Drug-Drug Interactions Using Physiologically Based Pharmacokinetic Modeling.

  • Authors : Hegde PV; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana.; Morse BL

Subjects: Drug Interactions*/Drug Interactions*/Drug Interactions*/physiology ; Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/metabolism ; Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/genetics

  • Source: Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2024 Jul 16; Vol. 52 (8), pp. 886-898. Date of Electronic Publication: 2024 Jul 16.Publisher: American Society for Pharmacology and Experimental Therapeutics, etc.] Country of Publication: United States NLM ID: 9421550 Publication Model:

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Academic Journal

Effect of Strong CYP3A4 Inhibition, CYP3A4 Induction, and OATP1B1/3 Inhibition on the Pharmacokinetics of a Single Oral Dose of Sotorasib.

  • Authors : Cardona P; Clinical Pharmacology, Modeling and Simulation, Amgen Inc., Thousand Oaks, CA, USA.; Dutta S

Subjects: Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/antagonists & inhibitors ; Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/metabolism ; Solute Carrier Organic Anion Transporter Family Member 1B3*/Solute Carrier Organic Anion Transporter Family Member 1B3*/Solute Carrier Organic Anion Transporter Family Member 1B3*/antagonists & inhibitors

  • Source: Clinical pharmacology in drug development [Clin Pharmacol Drug Dev] 2024 Jul; Vol. 13 (7), pp. 810-818. Date of Electronic Publication: 2024 Feb 29.Publisher: Wiley Country of Publication: United States NLM ID: 101572899 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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  • 1-10 of  359 results for ""Liver-Specific Organic Anion Transporter 1""