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Academic Journal

T0901317, an Agonist of Liver X Receptors, Attenuates Neuronal Apoptosis in Early Brain Injury after Subarachnoid Hemorrhage in Rats via Liver X Receptors/Interferon Regulatory Factor/P53 Upregulated Modulator of Apoptosis/Dynamin-1-Like Protein Pathway.

  • Authors : Dai J; Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.; Department of Physiology and Pharmacology, Loma Linda University, Loma Linda, CA 92354, USA.

Subjects: Brain Injuries/Brain Injuries/Brain Injuries/*genetics ; Dynamin I/Dynamin I/Dynamin I/*metabolism ; Hydrocarbons, Fluorinated/Hydrocarbons, Fluorinated/Hydrocarbons, Fluorinated/*therapeutic use

  • Source: Oxidative medicine and cellular longevity [Oxid Med Cell Longev] 2021 May 28; Vol. 2021, pp. 8849131. Date of Electronic Publication: 2021 May 28 (Print Publication: 2021).Publisher: Hindawi Pub. Corp Country of Publication: United States NLM ID: 101479826 Publication Model: eCollection Cited Medium: Internet ISSN:

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Academic Journal

Oxidative stress and Liver X Receptor agonist induce hepatocellular carcinoma in Non-alcoholic steatohepatitis model.

  • Authors : Shimizu Y; Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.; Tamura T

Subjects: Oxidative Stress*; Carcinoma, Hepatocellular/Carcinoma, Hepatocellular/Carcinoma, Hepatocellular/*etiology ; Hydrocarbons, Fluorinated/Hydrocarbons, Fluorinated/Hydrocarbons, Fluorinated/*adverse effects

  • Source: Journal of gastroenterology and hepatology [J Gastroenterol Hepatol] 2021 Mar; Vol. 36 (3), pp. 800-810. Date of Electronic Publication: 2020 Oct 05.Publisher: Blackwell Scientific Publications Country of Publication: Australia NLM ID: 8607909 Publication Model: Print-Electronic Cited Medium:

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Academic Journal

Inhibition of notch enhances the anti-atherosclerotic effects of LXR agonists while reducing fatty liver development in ApoE-deficient mice.

  • Authors : Hao Y; Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, School of Pharmacy, Yantai University, Yantai 264005, China.; Wang X

Subjects: Atherosclerosis/Atherosclerosis/Atherosclerosis/*drug therapy ; Diamines/Diamines/Diamines/*therapeutic use ; Fatty Liver/Fatty Liver/Fatty Liver/*drug therapy

  • Source: Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2020 Nov 01; Vol. 406, pp. 115211. Date of Electronic Publication: 2020 Aug 25.Publisher: Academic Press Country of Publication: United States NLM ID: 0416575 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

NPC1L1 and ABCG5/8 induction explain synergistic fecal cholesterol excretion in ob/ob mice co-treated with PPAR-α and LXR agonists.

Subjects: Feces* ; Liver X Receptors*/Liver X Receptors*/Liver X Receptors*/agonists ; Liver X Receptors*/Liver X Receptors*/Liver X Receptors*/metabolism

  • Source: Molecular and cellular biochemistry [Mol Cell Biochem] 2020 Oct; Vol. 473 (1-2), pp. 247-262. Date of Electronic Publication: 2020 Jul 13.Publisher: Springer Country of Publication: Netherlands NLM ID: 0364456 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Hepatic Transporter Alterations by Nuclear Receptor Agonist T0901317 in Sandwich-Cultured Human Hepatocytes: Proteomic Analysis and PBPK Modeling to Evaluate Drug-Drug Interaction Risk.

  • Authors : Ito K; Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (K.I., N.S., M.M.M., C.G., K.L.R.B.) and Drug Metabolism and Pharmacokinetics Research Department, Teijin Pharma Limited, Hino, Tokyo, Japan (K.I.).; Sjöstedt N

Subjects: Hepatocytes/Hepatocytes/Hepatocytes/*drug effects ; Hydrocarbons, Fluorinated/Hydrocarbons, Fluorinated/Hydrocarbons, Fluorinated/*pharmacology ; Liver X Receptors/Liver X Receptors/Liver X Receptors/*agonists

  • Source: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2020 May; Vol. 373 (2), pp. 261-268. Date of Electronic Publication: 2020 Mar 03.Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 0376362 Publication Model:

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Academic Journal

Apoptotic cell-mimicking gold nanocages loaded with LXR agonist for attenuating the progression of murine systemic lupus erythematosus.

  • Authors : Xu N; Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.; Li J

Subjects: Apoptosis* ; Drug Delivery Systems*; Gold/Gold/Gold/*administration & dosage

  • Source: Biomaterials [Biomaterials] 2019 Mar; Vol. 197, pp. 380-392. Date of Electronic Publication: 2019 Jan 23.Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 8100316 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

1α-Hydroxy derivatives of 7-dehydrocholesterol are selective liver X receptor modulators.

  • Authors : Endo-Umeda K; Division of Biochemistry, Department of Biomedical Sciences, Nihon University School of Medicine, 30-1 Oyaguchi-Kamicho, Itabashi-ku, Tokyo 173-8610, Japan.; Aoyama A

Subjects: Calcitriol/Calcitriol/Calcitriol/*pharmacology ; Cholesterol/Cholesterol/Cholesterol/*analogs & derivatives ; Dehydrocholesterols/Dehydrocholesterols/Dehydrocholesterols/*pharmacology

  • Source: The Journal of steroid biochemistry and molecular biology [J Steroid Biochem Mol Biol] 2017 Sep; Vol. 172, pp. 136-148. Date of Electronic Publication: 2017 Jul 20.Publisher: Pergamon Country of Publication: England NLM ID: 9015483 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1220

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Academic Journal

Activation of LXRα improves cardiac remodeling induced by pulmonary artery hypertension in rats.

  • Authors : Gong Y; Department of Cardiovascular Surgery, The Second Xiangya Hospital of Central South University, Changsha, China.; Yang Y

Subjects: Hydrocarbons, Fluorinated/Hydrocarbons, Fluorinated/Hydrocarbons, Fluorinated/*administration & dosage ; Hypertension, Pulmonary/Hypertension, Pulmonary/Hypertension, Pulmonary/*complications ; Hypertrophy, Right Ventricular/Hypertrophy, Right Ventricular/Hypertrophy, Right Ventricular/*drug therapy

  • Source: Scientific reports [Sci Rep] 2017 Jul 21; Vol. 7 (1), pp. 6169. Date of Electronic Publication: 2017 Jul 21.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

The effect of statins and the synthetic LXR agonist T0901317 on expression of ABCA1 transporter protein in human lung epithelial cell lines in vitro.

  • Authors : He P; Woolcock Emphysema Centre, Woolcock Institute of Medical Research, University of Sydney, NSW, Australia; School of Life Sciences, Faculty of Science, University of Technology Sydney, NSW, Australia.

Subjects: ATP Binding Cassette Transporter 1/ATP Binding Cassette Transporter 1/ATP Binding Cassette Transporter 1/*metabolism ; Epithelial Cells/Epithelial Cells/Epithelial Cells/*drug effects ; Hydrocarbons, Fluorinated/Hydrocarbons, Fluorinated/Hydrocarbons, Fluorinated/*pharmacology

  • Source: Pharmacological reports : PR [Pharmacol Rep] 2019 Dec; Vol. 71 (6), pp. 1219-1226. Date of Electronic Publication: 2019 Aug 17.Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 101234999 Publication Model: Print-Electronic Cited Medium:

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Academic Journal

TO901317 inhibits the development of hepatocellular carcinoma by LXRα/Glut1 decreasing glycometabolism.

  • Authors : Xiong T; Institute of Pharmacy and Pharmacology, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hunan, People's Republic of China.; School of Pharmacy, Changsha Medical University, Hunan, People's Republic of China.

Subjects: Carcinoma, Hepatocellular*/Carcinoma, Hepatocellular*/Carcinoma, Hepatocellular*/drug therapy ; Carcinoma, Hepatocellular*/Carcinoma, Hepatocellular*/Carcinoma, Hepatocellular*/metabolism ; Carcinoma, Hepatocellular*/Carcinoma, Hepatocellular*/Carcinoma, Hepatocellular*/pathology

  • Source: American journal of physiology. Gastrointestinal and liver physiology [Am J Physiol Gastrointest Liver Physiol] 2019 May 01; Vol. 316 (5), pp. G598-G607. Date of Electronic Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901227 Publication Model: Print-Electronic Cited Medium:

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  • 1-10 of  85 results for ""Hydrocarbons, Fluorinated""