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  • 1-10 of  993 results for ""Cytochrome P-450 CYP3A""

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Academic Journal

Human Multi-Lineage Liver Organoid Model Reveals Impairment of CYP3A4 Expression upon Repeated Exposure to Graphene Oxide.

  • Authors : Romaldini A; Nanoregulatory Group, D3 PharmaChemistry, Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genoa, Italy.; Spanò R

Subjects: Cytochrome P-450 CYP3A*/Cytochrome P-450 CYP3A*/Cytochrome P-450 CYP3A*/metabolism ; Cytochrome P-450 CYP3A*/Cytochrome P-450 CYP3A*/Cytochrome P-450 CYP3A*/genetics ; Organoids*/Organoids*/Organoids*/drug effects

  • Source: Cells [Cells] 2024 Sep 13; Vol. 13 (18). Date of Electronic Publication: 2024 Sep 13.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409

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Academic Journal

New insights into aflatoxin B1 mechanistic toxicology in cattle liver: an integrated approach using molecular docking and biological evaluation in CYP1A1 and CYP3A74 knockout BFH12 cell lines.

  • Authors : Iori S; Department of Comparative Biomedicine and Food Science, University of Padua, Viale Dell'Università 16, Legnaro, 35020, Padua, Italy.; Lahtela-Kakkonen M

Subjects: Aflatoxin B1*/Aflatoxin B1*/Aflatoxin B1*/toxicity ; Molecular Docking Simulation* ; Cytochrome P-450 CYP3A*/Cytochrome P-450 CYP3A*/Cytochrome P-450 CYP3A*/metabolism

  • Source: Archives of toxicology [Arch Toxicol] 2024 Sep; Vol. 98 (9), pp. 3097-3108. Date of Electronic Publication: 2024 Jun 04.Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417615 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Investigating the Correlation between Genotypes and Hepatic Protein Expression of CYP2C9, CYP2C19, CYP2D6, and CYP3A5 Using Postmortem Tissue from a Danish Population.

  • Authors : Pedersen KW; Department of Forensic Medicine, Aarhus University, Aarhus, Denmark (K.W.P., J.H., J.B.H., J.R.J.); and Department of Forensic Medicine, University of Copenhagen, Copenhagen, Denmark (J.D.A., C.B., J.B.).

Subjects: Liver*/Liver*/Liver*/metabolism ; Cytochrome P-450 CYP2D6*/Cytochrome P-450 CYP2D6*/Cytochrome P-450 CYP2D6*/genetics ; Cytochrome P-450 CYP2D6*/Cytochrome P-450 CYP2D6*/Cytochrome P-450 CYP2D6*/metabolism

  • Source: Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2024 Aug 14; Vol. 52 (9), pp. 975-980. Date of Electronic Publication: 2024 Aug 14.Publisher: American Society for Pharmacology and Experimental Therapeutics, etc.] Country of Publication: United States NLM ID: 9421550 Publication Model:

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Academic Journal

Prediction of Pediatric Pharmacokinetics for CYP3A4 Metabolized Drugs: Comparison of the Performance of Two Hepatic Ontogeny Within a Physiologically Based Pharmacokinetic Model.

  • Authors : Codaccioni M; Certara Predictive Technologies Division, Certara UK Limited, Sheffield, UK.; Southall RL

Subjects: Cytochrome P-450 CYP3A*/Cytochrome P-450 CYP3A*/Cytochrome P-450 CYP3A*/metabolism ; Models, Biological* ; Liver*/Liver*/Liver*/metabolism

  • Source: Journal of clinical pharmacology [J Clin Pharmacol] 2024 Sep; Vol. 64 (9), pp. 1083-1094. Date of Electronic Publication: 2024 May 02.Publisher: Wiley Country of Publication: England NLM ID: 0366372 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4604

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Academic Journal

Pregnane X receptor activation induces liver enlargement and regeneration and simultaneously promotes the metabolic activity of CYP3A1/2 and CYP2C6/11 in rats.

  • Authors : Bi G; NMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening & Guangdong-Hong Kong-Macao Joint Laboratory for New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.; Liang F

Subjects: Pregnane X Receptor*/Pregnane X Receptor*/Pregnane X Receptor*/metabolism ; Pregnane X Receptor*/Pregnane X Receptor*/Pregnane X Receptor*/genetics ; Liver Regeneration*/Liver Regeneration*/Liver Regeneration*/drug effects

  • Source: Basic & clinical pharmacology & toxicology [Basic Clin Pharmacol Toxicol] 2024 Aug; Vol. 135 (2), pp. 148-163. Date of Electronic Publication: 2024 Jun 17.Publisher: Blackwell Country of Publication: England NLM ID: 101208422 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1742-7843

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Academic Journal

Induction of hepatic CYP3A4 expression by cholesterol and cholic acid: Alterations of gene expression, microsomal activity, and pharmacokinetics.

  • Authors : Minegishi G; Department of Biopharmaceutics, Graduate School of Clinical Pharmacy, Meiji Pharmaceutical University, Kiyose, Japan.; Kobayashi Y

Subjects: Cholic Acid*/Cholic Acid*/Cholic Acid*/metabolism ; Cytochrome P-450 CYP3A*/Cytochrome P-450 CYP3A*/Cytochrome P-450 CYP3A*/metabolism ; Cytochrome P-450 CYP3A*/Cytochrome P-450 CYP3A*/Cytochrome P-450 CYP3A*/genetics

  • Source: Pharmacology research & perspectives [Pharmacol Res Perspect] 2024 Jun; Vol. 12 (3), pp. e1197.Publisher: John Wiley & Sons Ltd, British Pharmacological Society and American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States

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Academic Journal

A cautionary tale: Alien prolactins may induce lesser, no, or opposite effects to homologous hormone!

  • Authors : Barbee S; Division of Biomedical Sciences, School of Medicine, University of California, Riverside, California, USA.; Radecki KC

Subjects: Prolactin*/Prolactin*/Prolactin*/metabolism ; Liver*/Liver*/Liver*/metabolism ; Liver*/Liver*/Liver*/drug effects

  • Source: Journal of neuroendocrinology [J Neuroendocrinol] 2024 Jul; Vol. 36 (7), pp. e13225. Date of Electronic Publication: 2022 Dec 28.Publisher: Wiley & Sons Country of Publication: United States NLM ID: 8913461 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

KLF15-Cyp3a11 Axis Regulates Rifampicin-Induced Liver Injury.

  • Authors : Hou W; Department of Hepatobiliary Surgery, Anhui Province Key Laboratory of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China (W.H., X.G.); Cyagen Biosciences (Guangzhou) Inc. Guangzhou, Guangdong, China (K.-G.H.)

Subjects: Rifampin*/Rifampin*/Rifampin*/adverse effects ; Rifampin*/Rifampin*/Rifampin*/toxicity ; Rifampin*/Rifampin*/Rifampin*/pharmacology

  • Source: Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2024 Jun 17; Vol. 52 (7), pp. 606-613. Date of Electronic Publication: 2024 Jun 17.Publisher: American Society for Pharmacology and Experimental Therapeutics, etc.] Country of Publication: United States NLM ID: 9421550 Publication Model:

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Academic Journal

Parenteral nutrition emulsion inhibits CYP3A4 in an iPSC derived liver organoids testing platform.

Subjects: Organoids*/Organoids*/Organoids*/drug effects ; Organoids*/Organoids*/Organoids*/metabolism ; Cytochrome P-450 CYP3A*/Cytochrome P-450 CYP3A*/Cytochrome P-450 CYP3A*/metabolism

  • Source: Journal of pediatric gastroenterology and nutrition [J Pediatr Gastroenterol Nutr] 2024 May; Vol. 78 (5), pp. 1047-1058. Date of Electronic Publication: 2024 Mar 26.Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 8211545 Publication Model: Print-Electronic Cited Medium:

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Academic Journal

Toxicokinetic and toxicodynamic mixture effects of plant protection products: A case study.

  • Authors : Karaca M; German Federal Institute for Risk Assessment, Department of Pesticides Safety, Max-Dohrn-Straße 8-10, 10589, Berlin, Germany; Technical University of Berlin, Institute for Chemistry, Straße des 17. Juni 115, 10623, Berlin, Germany.

Subjects: Cytochrome P-450 CYP3A* ; Liver*; Toxicokinetics

  • Source: Regulatory toxicology and pharmacology : RTP [Regul Toxicol Pharmacol] 2023 Jun; Vol. 141, pp. 105400. Date of Electronic Publication: 2023 Apr 26.Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8214983 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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  • 1-10 of  993 results for ""Cytochrome P-450 CYP3A""