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Academic Journal

Aging Model for Analyzing Drug-Induced Proarrhythmia Risks Using Cardiomyocytes Differentiated from Progeria-Patient-Derived Induced Pluripotent Stem Cells.

Subjects: ARRHYTHMIA; PROARRHYTHMIA; PLURIPOTENT stem cellsUNITED States. Food & Drug Administration

  • Source: International Journal of Molecular Sciences; Aug2023, Vol. 24 Issue 15, p11959, 12p

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Establishment and validation of a torsade de pointes prediction model based on human iPSC‑derived cardiomyocytes.

Subjects: *PREDICTION models; *PROARRHYTHMIA; *INDUCED pluripotent stem cells

  • Source: Experimental & Therapeutic Medicine. Jan2023, Vol. 25 Issue 1, pN.PAG-N.PAG. 1p.

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Comprehensive in vitro proarrythmic evaluation of cardiomyocytes using a multi-electrode array.

Subjects: *PROARRHYTHMIA; *INHIBITION of potassium channels; *LONG QT syndrome diagnosis

  • Source: Journal of Pharmacological & Toxicological Methods. Sep2016, Vol. 81, p346-347. 2p.

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Academic Journal

Electrophysiologic actions of diverse CIPA compounds on Cor.4U cardiomyocytes.

Subjects: *PROARRHYTHMIA; *ACTION potentials; *INDUCED pluripotent stem cells

  • Source: Journal of Pharmacological & Toxicological Methods. Sep2016, Vol. 81, p342-343. 2p.

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Electrophysiological Characteristics of Human iPSC-Derived Cardiomyocytes for the Assessment of Drug-Induced Proarrhythmic Potential.

Subjects: *PROARRHYTHMIA; *DRUG side effects; *ELECTROPHYSIOLOGY

  • Source: PLoS ONE. 12/6/2016, Vol. 11 Issue 12, p1-14. 14p.

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Academic Journal

Proarrhythmia Risk Assessment in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Using the Maestro MEA Platform.

Subjects: *PROARRHYTHMIA; *INDUCED pluripotent stem cells; *HEART cells

  • Source: Toxicological Sciences. Sep2015, Vol. 147 Issue 1, p286-295. 10p. 2 Diagrams, 5 Charts, 5 Graphs.

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Academic Journal

CSAHi study: Validation of multi-electrode array systems (MEA60/2100) for prediction of drug-induced proarrhythmia using human iPS cell-derived cardiomyocytes -assessment of inter-facility and cells lot-to-lot-variability-.

Subjects: *PROARRHYTHMIA; *HEART cells; *CARDIAC contraction

  • Source: Regulatory Toxicology & Pharmacology: RTP. Jun2016, Vol. 77, p75-86. 12p.

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Academic Journal

Human iPSC-derived Cor.4U cardiomyocytes as a predictive tool for different comprehensive in vitro proarrhythmia assay endpoints.

Subjects: *PROARRHYTHMIA; *INDUCED pluripotent stem cells; *POTASSIUM antagonists

  • Source: Journal of Pharmacological & Toxicological Methods. Sep2016, Vol. 81, p384-384. 1p.

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Academic Journal

Predicting compound effects on cardiac repolarization and detection of proarrhythmia signals using human induced pluripotent stem cell-derived cardiomyocytes.

Subjects: *PROARRHYTHMIA; *INDUCED pluripotent stem cells; *HEART cells

  • Source: Journal of Pharmacological & Toxicological Methods. Sep2015, Vol. 75, p201-201. 1p.

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Academic Journal

LUF7244, an allosteric modulator/activator of Kv 11.1 channels, counteracts dofetilide-induced torsades de pointes arrhythmia in the chronic atrioventricular block dog model.

Subjects: INDUCED pluripotent stem cells; BONE lengthening (Orthopedics); ARRHYTHMIA

  • Source: British Journal of Pharmacology; Oct2019, Vol. 176 Issue 19, p3871-3885, 15p, 1 Diagram, 2 Charts, 6 Graphs

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  • 1-10 of  128 results for ""PROARRHYTHMIA""