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Academic Journal

Effects of CYP2C8 and SLCO1B1 Genetic Polymorphisms on Repaglinide Pharmacokinetics: A Systematic Review and Meta-Analysis.

  • Authors : Zhou S; Department of Pharmacy, Peking University First Hospital, Beijing 100034, China.; Xiang Q

Subjects: Polymorphism, Genetic*; Carbamates/Carbamates/Carbamates/*pharmacokinetics ; Cytochrome P-450 CYP2C8/Cytochrome P-450 CYP2C8/Cytochrome P-450 CYP2C8/*genetics

  • Source: Current drug metabolism [Curr Drug Metab] 2019; Vol. 20 (4), pp. 266-274.Publisher: Bentham Science Publishers Country of Publication: Netherlands NLM ID: 100960533 Publication Model: Print Cited Medium: Internet ISSN:

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Academic Journal

Strategies to improve the prediction accuracy of hepatic intrinsic clearance of three antidiabetic drugs: Application of the extended clearance concept and consideration of the effect of albumin on CYP2C metabolism and OATP1B-mediated hepatic uptake.

  • Authors : Fujino R; Drug Development Solutions Division, Sekisui Medical Co., Ltd, 2117 Muramatsu, Tokai, Ibaraki 319-1182, Japan. Electronic address: .; Hashizume K

Subjects: Models, Biological*; Albumins/Albumins/Albumins/*metabolism ; Cytochrome P-450 Enzyme System/Cytochrome P-450 Enzyme System/Cytochrome P-450 Enzyme System/*metabolism

  • Source: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences [Eur J Pharm Sci] 2018 Dec 01; Vol. 125, pp. 181-192. Date of Publisher: Elsevier Science B.V Country of Publication: Netherlands NLM ID: 9317982 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Interaction of Sulfonylureas with Liver Uptake Transporters OATP1B1 and OATP1B3.

  • Authors : Chen Y; Clinical Pharmacology Institute, Nanchang University, Nanchang, China.; Jiangxi Provincial Children's Hospital, Nanchang, China.

Subjects: Diabetes Mellitus, Type 2/Diabetes Mellitus, Type 2/Diabetes Mellitus, Type 2/*drug therapy ; Hypoglycemic Agents/Hypoglycemic Agents/Hypoglycemic Agents/*pharmacology ; Liver-Specific Organic Anion Transporter 1/Liver-Specific Organic Anion Transporter 1/Liver-Specific Organic Anion Transporter 1/*metabolism

  • Source: Basic & clinical pharmacology & toxicology [Basic Clin Pharmacol Toxicol] 2018 Aug; Vol. 123 (2), pp. 147-154. Date of Electronic Publication: 2018 Apr 10.Publisher: Blackwell Country of Publication: England NLM ID: 101208422 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1742-7843

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Academic Journal

Explaining Ethnic Variability of Transporter Substrate Pharmacokinetics in Healthy Asian and Caucasian Subjects with Allele Frequencies of OATP1B1 and BCRP: A Mechanistic Modeling Analysis.

  • Authors : Li R; Systems Modeling and Simulation, Medicine Design, World Wide Research and Development, Pfizer Inc., Cambridge, MA, USA. .; Barton HA

Subjects: Gene Frequency* ; Models, Biological* ; Pharmacogenomic Variants*

  • Source: Clinical pharmacokinetics [Clin Pharmacokinet] 2018 Apr; Vol. 57 (4), pp. 491-503.Publisher: Country of Publication: Switzerland NLM ID: 7606849 Publication Model: Print Cited Medium: Internet ISSN: 1179-1926 (Electronic)

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Academic Journal

Use of Physiologically Based Pharmacokinetic Modeling to Evaluate the Effect of Chronic Kidney Disease on the Disposition of Hepatic CYP2C8 and OATP1B Drug Substrates.

  • Authors : Tan ML; Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA.; Zhao P

Subjects: Models, Biological*; Cytochrome P-450 CYP2C8/Cytochrome P-450 CYP2C8/Cytochrome P-450 CYP2C8/*metabolism ; Hypoglycemic Agents/Hypoglycemic Agents/Hypoglycemic Agents/*metabolism

  • Source: Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2019 Mar; Vol. 105 (3), pp. 719-729. Date of Electronic Publication: 2018 Oct 26.Publisher: Wiley Country of Publication: United States NLM ID: 0372741 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-6535

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Academic Journal

CYP2C8 and SLCO1B1 Variants and Therapeutic Response to Thiazolidinediones in Patients With Type 2 Diabetes.

  • Authors : Dawed AY; Molecular and Clinical Medicine, School of Medicine, University of Dundee, Dundee, Scotland.; Donnelly L

Subjects: Cytochrome P-450 CYP2C8/Cytochrome P-450 CYP2C8/Cytochrome P-450 CYP2C8/*genetics ; Diabetes Mellitus, Type 2/Diabetes Mellitus, Type 2/Diabetes Mellitus, Type 2/*drug therapy ; Hypoglycemic Agents/Hypoglycemic Agents/Hypoglycemic Agents/*therapeutic use

  • Source: Diabetes care [Diabetes Care] 2016 Nov; Vol. 39 (11), pp. 1902-1908. Date of Electronic Publication: 2016 Jun 06.Publisher: American Diabetes Association Country of Publication: United States NLM ID: 7805975 Publication Model: Print-Electronic Cited Medium:

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Academic Journal

Elucidating rifampin's inducing and inhibiting effects on glyburide pharmacokinetics and blood glucose in healthy volunteers: unmasking the differential effects of enzyme induction and transporter inhibition for a drug and its primary metabolite.

  • Authors : Zheng HX; Department of Biopharmaceutical Sciences, University of California, San Francisco, San Francisco, California, USA.; Huang Y

Subjects: Anti-Infective Agents/Anti-Infective Agents/Anti-Infective Agents/*pharmacology ; Blood Glucose/Blood Glucose/Blood Glucose/*drug effects ; Ciprofloxacin/Ciprofloxacin/Ciprofloxacin/*pharmacology

  • Source: Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2009 Jan; Vol. 85 (1), pp. 78-85. Date of Electronic Publication: 2008 Oct 08.Publisher: Wiley Country of Publication: United States NLM ID: 0372741 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-6535

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Academic Journal

Polymorphic organic anion transporting polypeptide 1B1 is a major determinant of repaglinide pharmacokinetics.

  • Authors : Niemi M; Department of Clinical Pharmacology, University of Helsinki University Central Hospital, Helsinki. ; Backman JT

Subjects: Carbamates/Carbamates/Carbamates/*pharmacokinetics ; Cytochrome P-450 Enzyme System/Cytochrome P-450 Enzyme System/Cytochrome P-450 Enzyme System/*genetics ; Hypoglycemic Agents/Hypoglycemic Agents/Hypoglycemic Agents/*pharmacokinetics

  • Source: Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2005 Jun; Vol. 77 (6), pp. 468-78.Publisher: Wiley Country of Publication: United States NLM ID: 0372741 Publication Model: Print Cited Medium: Print ISSN: 0009-9236 (Print)

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Academic Journal

A variant of GRK5 is associated with the therapeutic efficacy of repaglinide in Chinese Han patients with type 2 diabetes mellitus.

  • Authors : Shang Z; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, China.; Department of Pharmacy, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.

Subjects: Carbamates/Carbamates/Carbamates/*therapeutic use ; Diabetes Mellitus, Type 2/Diabetes Mellitus, Type 2/Diabetes Mellitus, Type 2/*drug therapy ; Diabetes Mellitus, Type 2/Diabetes Mellitus, Type 2/Diabetes Mellitus, Type 2/*genetics

  • Source: Drug development research [Drug Dev Res] 2018 May; Vol. 79 (3), pp. 129-135. Date of Electronic Publication: 2018 Apr 16.Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8204468 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Quantitative Analysis of Complex Drug-Drug Interactions Between Repaglinide and Cyclosporin A/Gemfibrozil Using Physiologically Based Pharmacokinetic Models With In Vitro Transporter/Enzyme Inhibition Data.

  • Authors : Kim SJ; Sugiyama Laboratory, RIKEN Innovation Center, RIKEN Cluster for Industry Partnerships, RIKEN, Yokohama, Japan; Drug Evaluation Group, R&D Center, CJ HealthCare, Icheon, Korea. Electronic address: .

Subjects: Carbamates/Carbamates/Carbamates/*blood ; Cyclosporine/Cyclosporine/Cyclosporine/*pharmacology ; Enzyme Inhibitors/Enzyme Inhibitors/Enzyme Inhibitors/*pharmacology

  • Source: Journal of pharmaceutical sciences [J Pharm Sci] 2017 Sep; Vol. 106 (9), pp. 2715-2726. Date of Electronic Publication: 2017 May 04.Publisher: Elsevier Country of Publication: United States NLM ID: 2985195R Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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  • 1-10 of  30 results for ""Liver-Specific Organic Anion Transporter 1""