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Academic Journal

Advances in diarylpyrimidines and related analogues as HIV-1 nonnucleoside reverse transcriptase inhibitors (2019-2023).

  • Authors : Nie MZ; School of Chemical Engineering and Pharmacy, Pharmaceutical Research Institute, Wuhan Institute of Technology, Wuhan, 430205, China.; Zhang SS

Subjects: Pyrimidines*/Pyrimidines*/Pyrimidines*/chemistry ; Pyrimidines*/Pyrimidines*/Pyrimidines*/pharmacology ; Pyrimidines*/Pyrimidines*/Pyrimidines*/chemical synthesis

  • Source: European journal of medicinal chemistry [Eur J Med Chem] 2024 Dec 15; Vol. 280, pp. 116973. Date of Electronic Publication: 2024 Oct 18.Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Identification of novel diarylpyrimidine derivatives as potent HIV-1 non-nucleoside reverse transcriptase inhibitors against wild-type and K103N mutant viruses.

  • Authors : Jiang X; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Culture Road, 250012, Jinan, Shandong, PR China.; Zalloum WA

Subjects: Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/pharmacology ; Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/chemistry ; Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/chemical synthesis

  • Source: European journal of medicinal chemistry [Eur J Med Chem] 2024 Dec 15; Vol. 280, pp. 116941. Date of Electronic Publication: 2024 Oct 05.Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Fragment Addition-Based Design of Heteroaromatic-Biphenyl-DAPYs as Potent and Orally Available Non-nucleoside Reverse Transcriptase Inhibitors Featuring Significantly Enhanced Safety.

  • Authors : Huang WJ; Engineering Center of Catalysis and Synthesis for Chiral Molecules, Department of Chemistry, Fudan University, Shanghai 200433, China.; Shanghai Engineering Center of Industrial Asymmetric Catalysis for Chiral Drugs, Shanghai 200433, China.

Subjects: Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/pharmacology ; Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/chemistry ; Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/pharmacokinetics

  • Source: Journal of medicinal chemistry [J Med Chem] 2024 Oct 10; Vol. 67 (19), pp. 17568-17584. Date of Electronic Publication: 2024 Oct 01.Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Structure-based discovery of novel piperidine-biphenyl-DAPY derivatives as non-nucleoside reverse transcriptase inhibitors featuring improved potency, safety, and selectivity: From piperazine-biphenyl-DAPYs to piperidine-biphenyl-DAPYs.

  • Authors : Huang WJ; Engineering Center of Catalysis and Synthesis for Chiral Molecules, Department of Chemistry, Fudan University, Shanghai, 200433, China; Shanghai Engineering Center of Industrial Asymmetric Catalysis for Chiral Drugs, Shanghai, 200433, China.

Subjects: Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/pharmacology ; Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/chemistry ; Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/chemical synthesis

  • Source: European journal of medicinal chemistry [Eur J Med Chem] 2024 Oct 05; Vol. 276, pp. 116668. Date of Electronic Publication: 2024 Jul 10.Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

TAR RNA selective targeting ruthenium(II) complexes as HIV-1 reverse transcriptase inhibitors: On exploring structure-activity relationships of multiple positions.

  • Authors : Liu M; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Provincial Center for Research & Development of Natural Products, School of Pharmacy, Yunnan University, Kunming 650050, PR China.; Xie DD

Subjects: Ruthenium*/Ruthenium*/Ruthenium*/chemistry ; HIV-1*/HIV-1*/HIV-1*/drug effects ; HIV-1*/HIV-1*/HIV-1*/enzymology

  • Source: Journal of inorganic biochemistry [J Inorg Biochem] 2024 Oct; Vol. 259, pp. 112664. Date of Electronic Publication: 2024 Jul 15.Publisher: Elsevier Country of Publication: United States NLM ID: 7905788 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Discovery of Novel Amino Acids (Analogues)-Substituted Thiophene[3,2- d ]pyrimidine Derivatives as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: Design, Synthesis, and Biological Evaluation.

  • Authors : Zhuo Z; Key Laboratory of Chemical Biology (Ministry of Education), Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Culture Road, Jinan 250012, China.; Wang Z

Subjects: Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/pharmacology ; Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/chemistry ; Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/chemical synthesis

  • Source: International journal of molecular sciences [Int J Mol Sci] 2024 Aug 20; Vol. 25 (16). Date of Electronic Publication: 2024 Aug 20.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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2'-β-Methylselenyl nucleos(t)ide analogs as reverse transcriptase inhibitors against diverse HIV mutants.

  • Authors : Yoshida Y; Graduate School of Science, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, Aichi 464-8602, Japan.; Niimi Y

Subjects: Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/pharmacology ; Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/chemistry ; Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/chemical synthesis

  • Source: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2024 Aug 01; Vol. 110, pp. 117813. Date of Electronic Publication: 2024 Jun 22.Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Spectrum of Non-Nucleoside Reverse Transcriptase Inhibitor-Associated Drug Resistance Mutations in Persons Living with HIV-1 Receiving Rilpivirine.

Subjects: Rilpivirine*/Rilpivirine*/Rilpivirine*/therapeutic use ; HIV-1*/HIV-1*/HIV-1*/genetics ; HIV-1*/HIV-1*/HIV-1*/drug effects

  • Source: Viruses [Viruses] 2024 Oct 31; Vol. 16 (11). Date of Electronic Publication: 2024 Oct 31.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101509722 Publication Model: Electronic Cited Medium: Internet ISSN: 1999-4915

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Academic Journal

Design, Synthesis, Biological Evaluation and Molecular Docking Studies of New Thiazolidinone Derivatives as NNRTIs and SARS-CoV-2 Main Protease Inhibitors.

  • Authors : Fesatidou M; Department of Pharmaceutical Chemistry, School of Pharmacy, Aristotle University of Thessaloniki, Thessaloniki, 54124, Greece.; Petrou A

Subjects: Molecular Docking Simulation* ; Drug Design* ; SARS-CoV-2*/SARS-CoV-2*/SARS-CoV-2*/drug effects

  • Source: Chemistry & biodiversity [Chem Biodivers] 2024 Dec; Vol. 21 (12), pp. e202401697. Date of Electronic Publication: 2024 Oct 23.Publisher: Verlag Helvetica Chimica Acta Country of Publication: Switzerland NLM ID: 101197449 Publication Model: Print-Electronic Cited Medium:

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Expanding the Solvent/Protein Region Occupation of the Non-Nucleoside Reverse Transcriptase Inhibitor Binding Pocket for Improved Broad-Spectrum Anti-HIV-1 Efficacy: from Rigid Phenyl-Diarylpyrimidines to Flexible Hydrophilic Piperidine-Diarylpyrimidines.

  • Authors : Huang WJ; Engineering Center of Catalysis and Synthesis for Chiral Molecules, Department of Chemistry, Fudan University, Shanghai 200433, China.; Shanghai Engineering Center of Industrial Asymmetric Catalysis for Chiral Drugs, Shanghai 200433, China.

Subjects: Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/pharmacology ; Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/chemistry ; Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/chemical synthesis

  • Source: Journal of medicinal chemistry [J Med Chem] 2024 Nov 14; Vol. 67 (21), pp. 19889-19904. Date of Electronic Publication: 2024 Nov 05.Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet

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  • 1-10 of  6,219 results for ""REVERSE transcriptase inhibitors""