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Academic Journal

Identification of novel diarylpyrimidine derivatives as potent HIV-1 non-nucleoside reverse transcriptase inhibitors against wild-type and K103N mutant viruses.

  • Authors : Jiang X; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Culture Road, 250012, Jinan, Shandong, PR China.; Zalloum WA

Subjects: Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/pharmacology ; Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/chemistry ; Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/chemical synthesis

  • Source: European journal of medicinal chemistry [Eur J Med Chem] 2024 Dec 15; Vol. 280, pp. 116941. Date of Electronic Publication: 2024 Oct 05.Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Fragment Addition-Based Design of Heteroaromatic-Biphenyl-DAPYs as Potent and Orally Available Non-nucleoside Reverse Transcriptase Inhibitors Featuring Significantly Enhanced Safety.

  • Authors : Huang WJ; Engineering Center of Catalysis and Synthesis for Chiral Molecules, Department of Chemistry, Fudan University, Shanghai 200433, China.; Shanghai Engineering Center of Industrial Asymmetric Catalysis for Chiral Drugs, Shanghai 200433, China.

Subjects: Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/pharmacology ; Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/chemistry ; Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/pharmacokinetics

  • Source: Journal of medicinal chemistry [J Med Chem] 2024 Oct 10; Vol. 67 (19), pp. 17568-17584. Date of Electronic Publication: 2024 Oct 01.Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Structure-based discovery of novel piperidine-biphenyl-DAPY derivatives as non-nucleoside reverse transcriptase inhibitors featuring improved potency, safety, and selectivity: From piperazine-biphenyl-DAPYs to piperidine-biphenyl-DAPYs.

  • Authors : Huang WJ; Engineering Center of Catalysis and Synthesis for Chiral Molecules, Department of Chemistry, Fudan University, Shanghai, 200433, China; Shanghai Engineering Center of Industrial Asymmetric Catalysis for Chiral Drugs, Shanghai, 200433, China.

Subjects: Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/pharmacology ; Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/chemistry ; Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/chemical synthesis

  • Source: European journal of medicinal chemistry [Eur J Med Chem] 2024 Oct 05; Vol. 276, pp. 116668. Date of Electronic Publication: 2024 Jul 10.Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Discovery of Novel Amino Acids (Analogues)-Substituted Thiophene[3,2- d ]pyrimidine Derivatives as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: Design, Synthesis, and Biological Evaluation.

  • Authors : Zhuo Z; Key Laboratory of Chemical Biology (Ministry of Education), Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Culture Road, Jinan 250012, China.; Wang Z

Subjects: Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/pharmacology ; Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/chemistry ; Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/chemical synthesis

  • Source: International journal of molecular sciences [Int J Mol Sci] 2024 Aug 20; Vol. 25 (16). Date of Electronic Publication: 2024 Aug 20.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

Structure-guided design of novel biphenyl-quinazoline derivatives as potent non-nucleoside reverse transcriptase inhibitors featuring improved anti-resistance, selectivity, and solubility.

  • Authors : Wang JS; School of Pharmaceutical Sciences, Institute of Drug Discovery and Development, Zhengzhou University, Zhengzhou 450001, China; Engineering Center of Catalysis and Synthesis for Chiral Molecules, Department of Chemistry, Fudan University, Shanghai 200433, China

Subjects: Anti-HIV Agents*/Anti-HIV Agents*/Anti-HIV Agents*/pharmacology ; Anti-HIV Agents*/Anti-HIV Agents*/Anti-HIV Agents*/chemistry ; Anti-HIV Agents*/Anti-HIV Agents*/Anti-HIV Agents*/chemical synthesis

  • Source: Bioorganic chemistry [Bioorg Chem] 2024 Jun; Vol. 147, pp. 107340. Date of Electronic Publication: 2024 Apr 05.Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Tri-substituted 1,3,5-triazine-based analogs as effective HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs): A systematic review.

  • Authors : Khalifa Z; Department of Chemistry, Government College, Daman (Affiliated to Veer Narmad South Gujarat University, Surat), Daman, India.; Patel AB

Subjects: Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/pharmacology ; Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/chemistry ; Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/therapeutic use

  • Source: Drug development research [Drug Dev Res] 2024 Feb; Vol. 85 (1), pp. e22154.Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8204468 Publication Model: Print Cited Medium: Internet ISSN: 1098-2299

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Academic Journal

Strategies in the Design and Development of Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs).

  • Authors : Vanangamudi M; Department of Pharmaceutical Chemistry, Amity Institute of Pharmacy, Amity University Madhya Pradesh, Gwalior 474005, Madhya Pradesh, India.; Palaniappan S

Subjects: HIV Infections*/HIV Infections*/HIV Infections*/drug therapy ; HIV-1* ; Acquired Immunodeficiency Syndrome*/Acquired Immunodeficiency Syndrome*/Acquired Immunodeficiency Syndrome*/drug therapy

  • Source: Viruses [Viruses] 2023 Sep 25; Vol. 15 (10). Date of Electronic Publication: 2023 Sep 25.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101509722 Publication Model: Electronic Cited Medium: Internet ISSN: 1999-4915

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Academic Journal

Biochemical and structural comparisons of non-nucleoside reverse transcriptase inhibitors against feline and human immunodeficiency viruses.

Subjects: Anti-HIV Agents*/Anti-HIV Agents*/Anti-HIV Agents*/pharmacology ; Anti-HIV Agents*/Anti-HIV Agents*/Anti-HIV Agents*/therapeutic use ; HIV-1*/HIV-1*/HIV-1*/metabolism

  • Source: Journal of veterinary science [J Vet Sci] 2023 Sep; Vol. 24 (5), pp. e67.Publisher: Korean Society of Veterinary Science Country of Publication: Korea (South) NLM ID: 100964185 Publication Model: Print Cited Medium: Internet

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Academic Journal

Escaping from Flatland: Multiparameter Optimization Leads to the Discovery of Novel Tetrahydropyrido[4,3- d ]pyrimidine Derivatives as Human Immunodeficiency Virus-1 Non-nucleoside Reverse Transcriptase Inhibitors with Superior Antiviral Activities against Non-nucleoside Reverse Transcriptase Inhibitor-Resistant Variants and Favorable Drug-like Profiles.

  • Authors : Wang Z; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Culture Road, Jinan, Shandong 250012, P. R. China.; Sharma PP

Subjects: Anti-HIV Agents*/Anti-HIV Agents*/Anti-HIV Agents*/chemistry ; HIV Infections*/HIV Infections*/HIV Infections*/drug therapy ; HIV-1*/HIV-1*/HIV-1*/metabolism

  • Source: Journal of medicinal chemistry [J Med Chem] 2023 Jul 13; Vol. 66 (13), pp. 8643-8665. Date of Electronic Publication: 2023 May 31.Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Fragment Hopping-Based Design of Novel Biphenyl-DAPY Derivatives as Potent Non-Nucleoside Reverse Transcriptase Inhibitors Featuring Significantly Improved Anti-Resistance Efficacy.

  • Authors : Sang YL; Engineering Center of Catalysis and Synthesis for Chiral Molecules, Department of Chemistry, Fudan University, Shanghai 200433, China.; Shanghai Engineering Center of Industrial Asymmetric Catalysis for Chiral Drugs, Shanghai 200433, China.

Subjects: Anti-HIV Agents*/Anti-HIV Agents*/Anti-HIV Agents*/pharmacology ; HIV-1*/HIV-1*/HIV-1*/metabolism; Reverse Transcriptase Inhibitors/Reverse Transcriptase Inhibitors/Reverse Transcriptase Inhibitors/pharmacology

  • Source: Journal of medicinal chemistry [J Med Chem] 2023 Apr 13; Vol. 66 (7), pp. 4755-4767. Date of Electronic Publication: 2023 Mar 30.Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet

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  • 1-10 of  2,445 results for ""NUCLEOSIDE reverse transcriptase inhibitors""