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Academic Journal

Utility of Chimeric Mice with Humanized Livers for Predicting Hepatic Organic Anion-Transporting Polypeptide 1B-Mediated Clinical Drug-Drug Interactions.

  • Authors : Feng B; Drug Metabolism and Pharmacokinetics, Vertex Pharmaceuticals, Boston, Massachusetts (B.F., G.L., C.Z., S.L., H.H., J.W., H.G., S.K.) and PhoenixBio USA Corporation, New York, New York (Y.M.) .; Liang G

Subjects: Drug Interactions* ; Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/metabolism ; Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/antagonists & inhibitors

  • Source: Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2024 Sep 16; Vol. 52 (10), pp. 1073-1082. Date of Electronic Publication: 2024 Sep 16.Publisher: American Society for Pharmacology and Experimental Therapeutics, etc.] Country of Publication: United States NLM ID: 9421550 Publication Model:

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Academic Journal

Mechanistic Determinants of Daprodustat Drug-Drug Interactions and Pharmacokinetics in Hepatic Dysfunction and Chronic Kidney Disease: Significance of OATP1B-CYP2C8 Interplay.

  • Authors : Bi YA; Pharmacokinetics, Dynamics, and Metabolism, Pfizer R&D, Pfizer Inc., Groton, Connecticut, USA.; Jordan S

Subjects: Cytochrome P-450 CYP2C8*/Cytochrome P-450 CYP2C8*/Cytochrome P-450 CYP2C8*/metabolism ; Drug Interactions* ; Hepatocytes*/Hepatocytes*/Hepatocytes*/metabolism

  • Source: Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2024 Jun; Vol. 115 (6), pp. 1336-1345. Date of Electronic Publication: 2024 Feb 26.Publisher: Wiley Country of Publication: United States NLM ID: 0372741 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-6535

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Academic Journal

6-Hydroxyindole is an endogenous long-lasting OATP1B1 inhibitor elevated in renal failure patients.

  • Authors : Masuo Y; Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.; Fujita KI

Subjects: Hepatocytes/Hepatocytes/Hepatocytes/*drug effects ; Indoles/Indoles/Indoles/*pharmacology ; Liver-Specific Organic Anion Transporter 1/Liver-Specific Organic Anion Transporter 1/Liver-Specific Organic Anion Transporter 1/*antagonists & inhibitors

  • Source: Drug metabolism and pharmacokinetics [Drug Metab Pharmacokinet] 2020 Dec; Vol. 35 (6), pp. 555-562. Date of Electronic Publication: 2020 Sep 19.Publisher: Elsevier Country of Publication: England NLM ID: 101164773 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1880-0920

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Academic Journal

Scutellarin inhibition of the rosuvastatin uptake in rat hepatocytes and the competition for organic anion transporting polypeptide 1B1 in HEK293T cells.

  • Authors : Liu J; Clinical Pharmacology Institute, Nanchang University, Nanchang, Jiangxi, 330031, China. .; School of Pharmacy, JiangXi Medical College, Shangrao, Jiangxi, 334000, China. .

Subjects: Anions/Anions/Anions/*metabolism ; Apigenin/Apigenin/Apigenin/*pharmacology ; Glucuronates/Glucuronates/Glucuronates/*pharmacology

  • Source: Scientific reports [Sci Rep] 2020 Jan 28; Vol. 10 (1), pp. 1308. Date of Electronic Publication: 2020 Jan 28.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Regulation of OATP1B1 Function by Tyrosine Kinase-mediated Phosphorylation.

  • Authors : Hayden ER; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, New York.; Chen M

Subjects: HEK293 Cells/HEK293 Cells/HEK293 Cells/*metabolism ; Hepatocytes/Hepatocytes/Hepatocytes/*metabolism ; Liver-Specific Organic Anion Transporter 1/Liver-Specific Organic Anion Transporter 1/Liver-Specific Organic Anion Transporter 1/*physiology

  • Source: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2021 Aug 01; Vol. 27 (15), pp. 4301-4310. Date of Electronic Publisher: The Association Country of Publication: United States NLM ID: 9502500 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

cDNA Microarray Analysis and Influx Transporter OATP1B1 in Liver Cells After Exposure to Gadoxetate Disodium, a Gadolinium-based Contrast Agent in MRI Liver Imaging.

  • Authors : Lu CC; Department of Pharmacy, Buddhist Tzu Chi General Hospital, Hualien, Taiwan, R.O.C.; Chen WK

Subjects: Contrast Media/Contrast Media/Contrast Media/*pharmacology ; Gadolinium DTPA/Gadolinium DTPA/Gadolinium DTPA/*pharmacology ; Hepatocytes/Hepatocytes/Hepatocytes/*drug effects

  • Source: In vivo (Athens, Greece) [In Vivo] 2018 May-Jun; Vol. 32 (3), pp. 677-684.Publisher: International Institute of Anticancer Research Country of Publication: Greece NLM ID: 8806809 Publication Model: Print Cited Medium: Internet

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Academic Journal

Cell-to-Medium Concentration Ratio Overshoot in the Uptake of Statins by Human Hepatocytes in Suspension, but Not in Monolayer: Kinetic Analysis Suggesting a Partial Loss of Functional OATP1Bs.

  • Authors : Lee W; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, South Korea.; Koyama S

Subjects: Hepatocytes/Hepatocytes/Hepatocytes/*enzymology ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/Hydroxymethylglutaryl-CoA Reductase Inhibitors/Hydroxymethylglutaryl-CoA Reductase Inhibitors/*pharmacokinetics ; Liver-Specific Organic Anion Transporter 1/Liver-Specific Organic Anion Transporter 1/Liver-Specific Organic Anion Transporter 1/*metabolism

  • Source: The AAPS journal [AAPS J] 2020 Oct 15; Vol. 22 (6), pp. 133. Date of Electronic Publication: 2020 Oct 15.Publisher: American Association of Pharmaceutical Scientists Country of Publication: United States NLM ID: 101223209 Publication Model: Electronic Cited

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Academic Journal

Recent advances in preclinical in vitro approaches towards quantitative prediction of hepatic clearance and drug-drug interactions involving organic anion transporting polypeptide (OATP) 1B transporters.

  • Authors : Nozaki Y; Drug Metabolism and Pharmacokinetics Tsukuba, Eisai Co.,Ltd., 5-1-3 Tokodai, Tsukuba, Ibaraki, 300-2635, Japan. Electronic address: .; Izumi S

Subjects: Metabolic Clearance Rate*; Hepatocytes/Hepatocytes/Hepatocytes/*metabolism ; Liver-Specific Organic Anion Transporter 1/Liver-Specific Organic Anion Transporter 1/Liver-Specific Organic Anion Transporter 1/*metabolism

  • Source: Drug metabolism and pharmacokinetics [Drug Metab Pharmacokinet] 2020 Feb; Vol. 35 (1), pp. 56-70. Date of Electronic Publication: 2019 Dec 20.Publisher: Elsevier Country of Publication: England NLM ID: 101164773 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1880-0920

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Academic Journal

Hepatic Uptake Mechanism of Ophiopogonin D Mediated by Organic Anion Transporting Polypeptides.

  • Authors : Zhang W; Clinical Pharmacology Institute, Nanchang University, Bayi Road 461, Nanchang, 330006, People's Republic of China.; Chengdu Fifth People's Hospital, Chengdu, 611130, People's Republic of China.

Subjects: Hepatocytes/Hepatocytes/Hepatocytes/*metabolism ; Liver/Liver/Liver/*metabolism ; Liver-Specific Organic Anion Transporter 1/Liver-Specific Organic Anion Transporter 1/Liver-Specific Organic Anion Transporter 1/*metabolism

  • Source: European journal of drug metabolism and pharmacokinetics [Eur J Drug Metab Pharmacokinet] 2017 Aug; Vol. 42 (4), pp. 669-676.Publisher: Springer France Country of Publication: France NLM ID: 7608491 Publication Model: Print Cited Medium: Internet ISSN: 2107-0180

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Academic Journal

Organic Anion Transporting Polypeptides Contribute to the Disposition of Perfluoroalkyl Acids in Humans and Rats.

  • Authors : Zhao W; Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, Kansas City, Kansas 66160.; Zitzow JD

Subjects: Alkanesulfonic Acids/Alkanesulfonic Acids/Alkanesulfonic Acids/*metabolism ; Environmental Pollutants/Environmental Pollutants/Environmental Pollutants/*metabolism ; Fluorocarbons/Fluorocarbons/Fluorocarbons/*metabolism

  • Source: Toxicological sciences : an official journal of the Society of Toxicology [Toxicol Sci] 2017 Mar 01; Vol. 156 (1), pp. 84-95.Publisher: Oxford University Press Country of Publication: United States NLM ID: 9805461 Publication Model: Print Cited Medium: Internet ISSN:

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  • 1-10 of  72 results for ""Liver-Specific Organic Anion Transporter 1""