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Academic Journal

Harmine and exendin-4 combination therapy safely expands human β cell mass in vivo in a mouse xenograft system.

  • Authors : Rosselot C; Diabetes, Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Li Y

Subjects: Insulin-Secreting Cells*/Insulin-Secreting Cells*/Insulin-Secreting Cells*/drug effects ; Insulin-Secreting Cells*/Insulin-Secreting Cells*/Insulin-Secreting Cells*/metabolism ; Insulin-Secreting Cells*/Insulin-Secreting Cells*/Insulin-Secreting Cells*/pathology

  • Source: Science translational medicine [Sci Transl Med] 2024 Jul 10; Vol. 16 (755), pp. eadg3456. Date of Electronic Publication: 2024 Jul 10.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic

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Academic Journal

Harmine suppresses collagen production in hepatic stellate cells by inhibiting DYRK1B.

  • Authors : Yamaguchi M; Department of Pharmacology, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka City, Shizuoka, 422-8526, Japan. Electronic address: .; Ohbayashi S

Subjects: Collagen Type I, alpha 1 Chain*/Collagen Type I, alpha 1 Chain*/Collagen Type I, alpha 1 Chain*/antagonists & inhibitors ; Collagen Type I, alpha 1 Chain*/Collagen Type I, alpha 1 Chain*/Collagen Type I, alpha 1 Chain*/biosynthesis ; Harmine*/Harmine*/Harmine*/pharmacology

  • Source: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2022 Apr 16; Vol. 600, pp. 136-141. Date of Electronic Publication: 2022 Feb 16.Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Rational Design and Identification of Harmine-Inspired, N-Heterocyclic DYRK1A Inhibitors Employing a Functional Genomic In Vivo Drosophila Model System.

  • Authors : Huizar FJ; Department of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, IN 46556, USA.; Hill HM

Subjects: Drosophila Proteins/Drosophila Proteins/Drosophila Proteins/*antagonists & inhibitors ; Harmine/Harmine/Harmine/*analogs & derivatives ; Harmine/Harmine/Harmine/*pharmacology

  • Source: ChemMedChem [ChemMedChem] 2022 Feb 16; Vol. 17 (4), pp. e202100512. Date of Electronic Publication: 2022 Jan 27.Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101259013 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1860-7187

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Academic Journal

Design, synthesis and biological evaluation of harmine derivatives as potent GSK-3β/DYRK1A dual inhibitors for the treatment of Alzheimer's disease.

  • Authors : Liu W; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China; Department of Pharmacy, General Hospital of Northern Theater Command, Shenyang 110840, People's Republic of China.

Subjects: Alzheimer Disease/Alzheimer Disease/Alzheimer Disease/*drug therapy ; Glycogen Synthase Kinase 3 beta/Glycogen Synthase Kinase 3 beta/Glycogen Synthase Kinase 3 beta/*antagonists & inhibitors ; Harmine/Harmine/Harmine/*pharmacology

  • Source: European journal of medicinal chemistry [Eur J Med Chem] 2021 Oct 15; Vol. 222, pp. 113554. Date of Electronic Publication: 2021 May 29.Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

A natural compound harmine decreases melanin synthesis through regulation of the DYRK1A/NFATC3 pathway.

  • Authors : Park CH; Department of Dermatology, Seoul National University College of Medicine, Seoul, Republic of Korea; Laboratory of Cutaneous Aging Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea

Subjects: Harmine/Harmine/Harmine/*pharmacology ; Melanins/Melanins/Melanins/*antagonists & inhibitors ; NFATC Transcription Factors/NFATC Transcription Factors/NFATC Transcription Factors/*metabolism

  • Source: Journal of dermatological science [J Dermatol Sci] 2021 Jul; Vol. 103 (1), pp. 16-24. Date of Electronic Publication: 2021 May 15.Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9011485 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

How to Separate Kinase Inhibition from Undesired Monoamine Oxidase A Inhibition-The Development of the DYRK1A Inhibitor AnnH75 from the Alkaloid Harmine.

  • Authors : Wurzlbauer A; Department of Pharmacy-Center for Drug Research, Ludwig-Maximilians University, 81377 Munich, Germany.; Rüben K

Subjects: Harmine/Harmine/Harmine/*metabolism ; Monoamine Oxidase/Monoamine Oxidase/Monoamine Oxidase/*metabolism ; Protein Kinase Inhibitors/Protein Kinase Inhibitors/Protein Kinase Inhibitors/*chemistry

  • Source: Molecules (Basel, Switzerland) [Molecules] 2020 Dec 16; Vol. 25 (24). Date of Electronic Publication: 2020 Dec 16.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049

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Academic Journal

Synthesis and Biological Validation of a Harmine-Based, Central Nervous System (CNS)-Avoidant, Selective, Human β-Cell Regenerative Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase A (DYRK1A) Inhibitor.

  • Authors : Kumar K; Drug Discovery Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, United States.; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029, United States.

Subjects: Harmine/Harmine/Harmine/*analogs & derivatives ; Harmine/Harmine/Harmine/*pharmacology ; Insulin-Secreting Cells/Insulin-Secreting Cells/Insulin-Secreting Cells/*drug effects

  • Source: Journal of medicinal chemistry [J Med Chem] 2020 Mar 26; Vol. 63 (6), pp. 2986-3003. Date of Electronic Publication: 2020 Feb 19.Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Combined Inhibition of DYRK1A, SMAD, and Trithorax Pathways Synergizes to Induce Robust Replication in Adult Human Beta Cells.

  • Authors : Wang P; Diabetes, Obesity, and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Karakose E

Subjects: Diabetes Mellitus, Type 2*/Diabetes Mellitus, Type 2*/Diabetes Mellitus, Type 2*/drug therapy ; Diabetes Mellitus, Type 2*/Diabetes Mellitus, Type 2*/Diabetes Mellitus, Type 2*/metabolism ; Insulin-Secreting Cells*/Insulin-Secreting Cells*/Insulin-Secreting Cells*/drug effects

  • Source: Cell metabolism [Cell Metab] 2019 Mar 05; Vol. 29 (3), pp. 638-652.e5. Date of Electronic Publication: 2018 Dec 20.Publisher: Cell Press Country of Publication: United States NLM ID: 101233170 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Development of Kinase-Selective, Harmine-Based DYRK1A Inhibitors that Induce Pancreatic Human β-Cell Proliferation.

Subjects: Harmine/Harmine/Harmine/*chemistry ; Insulin-Secreting Cells/Insulin-Secreting Cells/Insulin-Secreting Cells/*drug effects ; Protein Kinase Inhibitors/Protein Kinase Inhibitors/Protein Kinase Inhibitors/*chemistry

  • Source: Journal of medicinal chemistry [J Med Chem] 2018 Sep 13; Vol. 61 (17), pp. 7687-7699. Date of Electronic Publication: 2018 Aug 21.Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Structure-Based Design and Synthesis of Harmine Derivatives with Different Selectivity Profiles in Kinase versus Monoamine Oxidase Inhibition.

  • Authors : Bálint B; Servier Research Institute of Medicinal Chemistry, Záhony u. 7, 1031, Budapest, Hungary.; Wéber C

Subjects: Drug Design*; Harmine/Harmine/Harmine/*pharmacology ; Monoamine Oxidase/Monoamine Oxidase/Monoamine Oxidase/*metabolism

  • Source: ChemMedChem [ChemMedChem] 2017 Jun 21; Vol. 12 (12), pp. 932-939. Date of Electronic Publication: 2017 Apr 06.Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101259013 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1860-7187

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  • 1-10 of  21 results for ""Dyrk Kinases""