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Academic Journal

Reassessing granzyme B: unveiling perforin-independent versatility in immune responses and therapeutic potentials.

  • Authors : Thompson R; Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland Baltimore School of Medicine, Baltimore, MD, United States.; Cao X

Subjects: Granzymes*/Granzymes*/Granzymes*/metabolism ; Perforin*/Perforin*/Perforin*/metabolism ; T-Lymphocytes, Cytotoxic*/T-Lymphocytes, Cytotoxic*/T-Lymphocytes, Cytotoxic*/immunology

  • Source: Frontiers in immunology [Front Immunol] 2024 May 23; Vol. 15, pp. 1392535. Date of Electronic Publication: 2024 May 23 (Print Publication: 2024).Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet

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Academic Journal

Co-encapsulation of granzyme B and perforin in nanocapsules for tumour therapy: biomimicking immune cells.

  • Authors : Shi Z; Department of Medical Laboratory, School of Medical Technology, Tianjin Medical University, Tianjin 300203, China; The Third Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China.

Subjects: Granzymes*/Granzymes*/Granzymes*/metabolism ; Nanocapsules*/Nanocapsules*/Nanocapsules*/chemistry ; Perforin*/Perforin*/Perforin*/metabolism

  • Source: Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2024 May; Vol. 369, pp. 658-667. Date of Electronic Publication: 2024 Apr 11.Publisher: Elsevier Science Publishers Country of Publication: Netherlands NLM ID: 8607908 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Peroxisome Proliferator-Activated Receptor δ Suppresses the Cytotoxicity of CD8+ T Cells by Inhibiting RelA DNA-Binding Activity.

  • Authors : Cen B; Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina.; Wei J

Subjects: Transcription Factor RelA*/Transcription Factor RelA*/Transcription Factor RelA*/metabolism ; Granzymes*/Granzymes*/Granzymes*/metabolism ; CD8-Positive T-Lymphocytes*/CD8-Positive T-Lymphocytes*/CD8-Positive T-Lymphocytes*/immunology

  • Source: Cancer research communications [Cancer Res Commun] 2024 Oct 01; Vol. 4 (10), pp. 2673-2684.Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 9918281580506676 Publication Model: Print Cited Medium:

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Academic Journal

SIT1 identifies circulating hypoactive T cells with elevated cytotoxic molecule secretion in systemic lupus erythematosus patients.

  • Authors : Hasimu A; Department of Clinical Laboratory, Peking University People's Hospital, 11# Xizhimen South Street, Beijing, China.; Bahabayi A

Subjects: CD4-Positive T-Lymphocytes*/CD4-Positive T-Lymphocytes*/CD4-Positive T-Lymphocytes*/immunology ; CD4-Positive T-Lymphocytes*/CD4-Positive T-Lymphocytes*/CD4-Positive T-Lymphocytes*/metabolism ; CD8-Positive T-Lymphocytes*/CD8-Positive T-Lymphocytes*/CD8-Positive T-Lymphocytes*/immunology

  • Source: Immunologic research [Immunol Res] 2024 Aug; Vol. 72 (4), pp. 754-765. Date of Electronic Publication: 2024 May 01.Publisher: Humana Press Country of Publication: United States NLM ID: 8611087 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

The presence of cytotoxic CD4 and exhausted-like CD8+ T-cells is a signature of active tuberculosis.

  • Authors : Flores-Gonzalez J; Laboratory of Integrative Immunology, Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Mexico City 14080. Mexico.; Ramón-Luing LA

Subjects: CD8-Positive T-Lymphocytes*/CD8-Positive T-Lymphocytes*/CD8-Positive T-Lymphocytes*/immunology ; CD8-Positive T-Lymphocytes*/CD8-Positive T-Lymphocytes*/CD8-Positive T-Lymphocytes*/metabolism ; CD4-Positive T-Lymphocytes*/CD4-Positive T-Lymphocytes*/CD4-Positive T-Lymphocytes*/immunology

  • Source: Biochimica et biophysica acta. Molecular basis of disease [Biochim Biophys Acta Mol Basis Dis] 2024 Aug; Vol. 1870 (6), pp. 167219. Date of Electronic Publication: 2024 May 10.Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101731730 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Single-Cell Analysis Reveals That CD47 mRNA Expression Correlates with Immune Cell Activation, Antiviral Isgs, and Cytotoxicity.

  • Authors : Cham LB; Department of Infectious Diseases, Aarhus University Hospital, Aarhus 8200, Denmark, .; Department of Clinical Medicine, Aarhus University, Aarhus 8200, Denmark.

Subjects: CD47 Antigen*/CD47 Antigen*/CD47 Antigen*/metabolism ; CD47 Antigen*/CD47 Antigen*/CD47 Antigen*/genetics ; CD8-Positive T-Lymphocytes*/CD8-Positive T-Lymphocytes*/CD8-Positive T-Lymphocytes*/metabolism

  • Source: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology [Cell Physiol Biochem] 2024 Jul 26; Vol. 58 (4), pp. Publisher: Cell Physiol Biochem Press GmbH & Co KG Country of Publication: Germany NLM ID: 9113221 Publication Model: Print Cited Medium: Internet

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Academic Journal

Disruption of IFNγ, GZMB, PRF1, or LYST Results in Reduced Suppressive Function in Human CD8+ T Cells.

  • Authors : Vemulawada C; Department of Pathology, University of Iowa Health Care, Iowa City.; Iowa City Veterans Affairs Medical Center, Iowa City, IA.

Subjects: CD8-Positive T-Lymphocytes*/CD8-Positive T-Lymphocytes*/CD8-Positive T-Lymphocytes*/immunology ; Interferon-gamma*/Interferon-gamma*/Interferon-gamma*/immunology ; Interferon-gamma*/Interferon-gamma*/Interferon-gamma*/metabolism

  • Source: Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2024 Jun 01; Vol. 212 (11), pp. 1722-1732.Publisher: American Association of Immunologists Country of Publication: United States NLM ID: 2985117R Publication Model: Print Cited Medium: Internet

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Academic Journal

Granzyme B and perforin produced by SEC2 mutant-activated human CD4 + T cells and CD8 + T cells induce apoptosis of K562 leukemic cells by the mitochondrial apoptotic pathway.

  • Authors : Zhang G; Department of Pathophysiology, College of Basic Medical Science, China Medical University, No. 77 Puhe Road, Shenyang North New Area District, 110122 Shenyang, Liaoning, People's Republic of China.; Zheng G

Subjects: Apoptosis*; CD4-Positive T-Lymphocytes/CD4-Positive T-Lymphocytes/CD4-Positive T-Lymphocytes/*immunology ; CD8-Positive T-Lymphocytes/CD8-Positive T-Lymphocytes/CD8-Positive T-Lymphocytes/*immunology

  • Source: International journal of biological macromolecules [Int J Biol Macromol] 2021 Nov 01; Vol. 190, pp. 284-290. Date of Electronic Publication: 2021 Sep 04.Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Tim-3 suppresses the killing effect of Vγ9Vδ2 T cells on colon cancer cells by reducing perforin and granzyme B expression.

  • Authors : Li X; Department of Gastroenterology, The First Affiliated Hospital of Soochow University, 188 Shizi Road, Suzhou, China.; Lu H

Subjects: Colonic Neoplasms/Colonic Neoplasms/Colonic Neoplasms/*immunology ; Granzymes/Granzymes/Granzymes/*metabolism ; Hepatitis A Virus Cellular Receptor 2/Hepatitis A Virus Cellular Receptor 2/Hepatitis A Virus Cellular Receptor 2/*metabolism

  • Source: Experimental cell research [Exp Cell Res] 2020 Jan 01; Vol. 386 (1), pp. 111719. Date of Electronic Publication: 2019 Nov 11.Publisher: Academic Press Country of Publication: United States NLM ID: 0373226 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Natural Killer Cell Group 7 Sequence in Cytotoxic Cells Optimizes Exocytosis of Lytic Granules Essential for the Perforin-Dependent, but Not Fas Ligand-Dependent, Cytolytic Pathway.

  • Authors : Morikawa Y; Department of Immunology, Kitasato University School of Medicine, Kanagawa, Japan; and.

Subjects: Granzymes/Granzymes/Granzymes/*metabolism ; Killer Cells, Natural/Killer Cells, Natural/Killer Cells, Natural/*immunology ; Membrane Proteins/Membrane Proteins/Membrane Proteins/*genetics

  • Source: ImmunoHorizons [Immunohorizons] 2021 Apr 28; Vol. 5 (4), pp. 234-245. Date of Electronic Publication: 2021 Apr 28.Publisher: American Association of Immunologists, Inc Country of Publication: United States NLM ID: 101708159 Publication Model: Electronic Cited Medium:

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  • 1-10 of  1,117 results for ""Perforin""