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Academic Journal

Voacangine protects hippocampal neuronal cells against oxygen-glucose deprivation/reoxygenation-caused oxidative stress and ferroptosis by activating the PI3K-Akt-FoxO signaling.

  • Authors : Li Y; Medical College, Zhengzhou University of Industrial Technology, No. 16 Xueyuan Road, Xinzheng, Henan Province, 451100, China.; Sun Y

Subjects: Oxidative Stress*/Oxidative Stress*/Oxidative Stress*/drug effects ; Ferroptosis*/Ferroptosis*/Ferroptosis*/drug effects ; Hippocampus*/Hippocampus*/Hippocampus*/drug effects

  • Source: Journal of applied toxicology : JAT [J Appl Toxicol] 2024 Aug; Vol. 44 (8), pp. 1246-1256. Date of Electronic Publication: 2024 Apr 26.Publisher: John Wiley And Sons Country of Publication: England NLM ID: 8109495 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Fungal Depsidones Stimulate AKT-Dependent Glucose Uptake in 3T3-L1 Adipocytes.

  • Authors : Chantarasakha K; National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), 111 Thailand Science Park, Phahonyothin Road, Klong Luang, Pathumthani 12120, Thailand.; Yangchum A

Subjects: Adipocytes*/Adipocytes*/Adipocytes*/metabolism ; Adipocytes*/Adipocytes*/Adipocytes*/drug effects ; Glucose*/Glucose*/Glucose*/metabolism

  • Source: Journal of natural products [J Nat Prod] 2024 Jul 26; Vol. 87 (7), pp. 1673-1681. Date of Electronic Publication: 2024 Apr 10.Publisher: American Society of Pharmacognosy Country of Publication: United States NLM ID: 7906882 Publication Model: Print-Electronic Cited Medium:

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Academic Journal

SP1 promotes high glucose-induced lens epithelial cell viability, migration and epithelial-mesenchymal transition via regulating FGF7 and PI3K/AKT pathway.

  • Authors : Wang L; Department of Ophthalmology, Ophthalmology Center, Taizhou Hospital of Zhejiang Province, 150 Ximen Street, Linhai, 317000, China.; Zhang X

Subjects: Epithelial-Mesenchymal Transition*/Epithelial-Mesenchymal Transition*/Epithelial-Mesenchymal Transition*/drug effects ; Sp1 Transcription Factor*/Sp1 Transcription Factor*/Sp1 Transcription Factor*/metabolism ; Sp1 Transcription Factor*/Sp1 Transcription Factor*/Sp1 Transcription Factor*/genetics

  • Source: International ophthalmology [Int Ophthalmol] 2024 Jul 06; Vol. 44 (1), pp. 316. Date of Electronic Publication: 2024 Jul 06.Publisher: Kluwer Country of Publication: Netherlands NLM ID: 7904294 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-2630

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Academic Journal

Phillyrin alleviates high glucose-induced oxidative stress and inflammation in HBZY-1 cells through inhibition of the PI3K/Akt signaling pathway.

  • Authors : Yang C; Department of Pharmacy, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China.; Beijing Key Laboratory of Evaluation of Rational Drug Use, Beijing 100038, China.

Subjects: Oxidative Stress*/Oxidative Stress*/Oxidative Stress*/drug effects ; Proto-Oncogene Proteins c-akt*/Proto-Oncogene Proteins c-akt*/Proto-Oncogene Proteins c-akt*/metabolism ; Signal Transduction*/Signal Transduction*/Signal Transduction*/drug effects

  • Source: The Journal of pharmacy and pharmacology [J Pharm Pharmacol] 2024 Jul 05; Vol. 76 (7), pp. 776-787.Publisher: Oxford University Press Country of Publication: England NLM ID: 0376363 Publication Model: Print Cited Medium: Internet ISSN:

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Academic Journal

TLQP-21 facilitates diabetic wound healing by inducing angiogenesis through alleviating high glucose-induced injuries on endothelial progenitor cells.

  • Authors : Fang Y; Laboratory Medicine Center, Department of Clinical Laboratory, Affiliated People's Hospital, Zhejiang Provincial People's Hospital, Hangzhou Medical College, No. 158, Shangtang Road, Gongshu District, Hangzhou Zhejiang, 310053, China.; Zhu Y

Subjects: Endothelial Progenitor Cells*/Endothelial Progenitor Cells*/Endothelial Progenitor Cells*/drug effects ; Endothelial Progenitor Cells*/Endothelial Progenitor Cells*/Endothelial Progenitor Cells*/metabolism ; Wound Healing*/Wound Healing*/Wound Healing*/drug effects

  • Source: Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2024 Jul; Vol. 397 (7), pp. 4993-5004. Date of Electronic Publication: 2024 Jan 06.Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0326264 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

PM2.5 potentiates oxygen glucose deprivation-induced neurovascular unit damage via inhibition of the Akt/β-catenin pathway and autophagy dysregulation.

  • Authors : Kim D; College of Pharmacy Institute of Pharmaceutical Science and Technology, Hanyang University, Ansan, 15588, South Korea.; Gil J

Subjects: Particulate Matter* ; Autophagy*/Autophagy*/Autophagy*/drug effects ; Rats, Sprague-Dawley*

  • Source: Environmental pollution (Barking, Essex : 1987) [Environ Pollut] 2024 Oct 15; Vol. 359, pp. 124728. Date of Electronic Publication: 2024 Aug 14.Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 8804476 Publication Model: Print-Electronic Cited Medium:

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Academic Journal

Short-Term Preconditioning with Insulin and Glucose Efficiently Protected the Kidney Against Ischemia-Reperfusion Injury via the P-AKT-Bax-Caspase-3 Signaling Pathway in Mice.

  • Authors : Sun L; Department of Anesthesiology and Perioperative Medicine, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, People's Republic of China.; Bing H

Subjects: Reperfusion Injury*/Reperfusion Injury*/Reperfusion Injury*/drug therapy ; Reperfusion Injury*/Reperfusion Injury*/Reperfusion Injury*/prevention & control ; Reperfusion Injury*/Reperfusion Injury*/Reperfusion Injury*/metabolism

  • Source: Drug design, development and therapy [Drug Des Devel Ther] 2024 Jun 20; Vol. 18, pp. 2461-2474. Date of Electronic Publication: 2024 Jun 20 (Print Publication: 2024).Publisher: Dove Press Limited Country of Publication: New Zealand NLM ID: 101475745 Publication Model: eCollection Cited Medium: Internet ISSN:

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Academic Journal

Cell division cycle 42 attenuates high glucose-treated renal tubular epithelial cell apoptosis, fibrosis, and inflammation, but activates the PAK1/AKT pathway.

  • Authors : Zheng S; Clinical Integrated Traditional Chinese and Western Medicine, Heilongjiang University of Chinese Medicine, Harbin, 150040, China.; Zhao N

Subjects: p21-Activated Kinases*/p21-Activated Kinases*/p21-Activated Kinases*/metabolism ; Apoptosis*/Apoptosis*/Apoptosis*/drug effects ; Proto-Oncogene Proteins c-akt*/Proto-Oncogene Proteins c-akt*/Proto-Oncogene Proteins c-akt*/metabolism

  • Source: Clinical and experimental nephrology [Clin Exp Nephrol] 2024 Jun; Vol. 28 (6), pp. 513-521. Date of Electronic Publication: 2024 Feb 28.Publisher: Springer Country of Publication: Japan NLM ID: 9709923 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1437-7799

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Academic Journal

High glucose inhibits autophagy and promotes the proliferation and metastasis of colorectal cancer through the PI3K/AKT/mTOR pathway.

  • Authors : Li F; Department of Pharmacology, West China School of Basic Science and Forensic Medicine, Sichuan University, Chengdu, China.; Wan X

Subjects: Colorectal Neoplasms*/Colorectal Neoplasms*/Colorectal Neoplasms*/pathology ; Colorectal Neoplasms*/Colorectal Neoplasms*/Colorectal Neoplasms*/metabolism ; TOR Serine-Threonine Kinases*/TOR Serine-Threonine Kinases*/TOR Serine-Threonine Kinases*/metabolism

  • Source: Cancer medicine [Cancer Med] 2024 Jun; Vol. 13 (11), pp. e7382.Publisher: John Wiley & Sons Ltd Country of Publication: United States NLM ID: 101595310 Publication Model: Print Cited Medium: Internet ISSN:

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Academic Journal

The PI3K/Akt Pathway and Glucose Metabolism: A Dangerous Liaison in Cancer.

  • Authors : Fontana F; Department of Pharmacological and Biomolecular Sciences 'Rodolfo Paoletti', Università degli Studi di Milano, Milan, Italy.; Giannitti G

Subjects: Neoplasms*/Neoplasms*/Neoplasms*/metabolism ; Proto-Oncogene Proteins c-akt*/Proto-Oncogene Proteins c-akt*/Proto-Oncogene Proteins c-akt*/metabolism ; Glucose*/Glucose*/Glucose*/metabolism

  • Source: International journal of biological sciences [Int J Biol Sci] 2024 May 27; Vol. 20 (8), pp. 3113-3125. Date of Electronic Publication: 2024 May 27 (Print Publication: 2024).Publisher: Ivyspring International Country of Publication: Australia NLM ID: 101235568 Publication Model: eCollection Cited Medium: Internet ISSN:

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  • 1-10 of  1,159 results for ""Proto-Oncogene Proteins c-akt""