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Academic Journal

Novel Pyrido[4,3- d ]pyrimidine Derivatives as Potential Sterol 14α-Demethylase Inhibitors: Design, Synthesis, Inhibitory Activity, and Molecular Modeling.

  • Authors : Yan Y; School of Science, Xihua University, Chengdu 610039, PR China.; Xie X

Subjects: 14-alpha Demethylase Inhibitors*/14-alpha Demethylase Inhibitors*/14-alpha Demethylase Inhibitors*/pharmacology ; 14-alpha Demethylase Inhibitors*/14-alpha Demethylase Inhibitors*/14-alpha Demethylase Inhibitors*/chemistry ; 14-alpha Demethylase Inhibitors*/14-alpha Demethylase Inhibitors*/14-alpha Demethylase Inhibitors*/chemical synthesis Botrytis cinerea; Pyricularia oryzae; Sclerotinia sclerotiorum

  • Source: Journal of agricultural and food chemistry [J Agric Food Chem] 2024 May 29; Vol. 72 (21), pp. 12260-12269. Date of Electronic Publication: 2024 May 17.Publisher: American Chemical Society Country of Publication: United States NLM ID: 0374755 Publication Model: Print-Electronic Cited Medium: Internet

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A binding mode hypothesis for prothioconazole binding to CYP51 derived from first principles quantum chemistry.

  • Authors : Beck ME; Division Crop Science, Bayer AG, Alfred-Nobel-Str. 50, 40789, Monheim am Rhein, Germany. .; Negroni J

Subjects: 14-alpha Demethylase Inhibitors/14-alpha Demethylase Inhibitors/14-alpha Demethylase Inhibitors/*pharmacology ; Fungal Proteins/Fungal Proteins/Fungal Proteins/*metabolism ; Fungicides, Industrial/Fungicides, Industrial/Fungicides, Industrial/*pharmacology

  • Source: Journal of computer-aided molecular design [J Comput Aided Mol Des] 2021 Apr; Vol. 35 (4), pp. 493-503. Date of Electronic Publication: 2020 Jul 08.Publisher: Springer Country of Publication: Netherlands NLM ID: 8710425 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Pfcyp51 exclusively determines reduced sensitivity to 14α-demethylase inhibitor fungicides in the banana black Sigatoka pathogen Pseudocercospora fijiensis.

  • Authors : Chong P; ESPOL Polythecnic University, Escuela Superior Politécnica del Litoral, ESPOL, Centro de Investigaciones Biotecnológicas del Ecuador, Laboratorio de Fitopatología, Guayaquil, Ecuador.; Laboratory of Phytopathology, Wageningen University and Research, The Netherlands, Wageningen, the Netherlands.

Subjects: 14-alpha Demethylase Inhibitors/14-alpha Demethylase Inhibitors/14-alpha Demethylase Inhibitors/*metabolism ; Ascomycota/Ascomycota/Ascomycota/*genetics ; Fungal Proteins/Fungal Proteins/Fungal Proteins/*metabolism

  • Source: PloS one [PLoS One] 2019 Oct 17; Vol. 14 (10), pp. e0223858. Date of Electronic Publication: 2019 Oct 17 (Print Publication: 2019).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet

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Academic Journal

Antifungal screening and in silico mechanistic studies of an in-house azole library.

  • Authors : Sari S; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey.; Kart D

Subjects: 14-alpha Demethylase Inhibitors/14-alpha Demethylase Inhibitors/14-alpha Demethylase Inhibitors/*chemical synthesis ; Antifungal Agents/Antifungal Agents/Antifungal Agents/*chemical synthesis ; Azoles/Azoles/Azoles/*chemical synthesis Systemic candidiasis

  • Source: Chemical biology & drug design [Chem Biol Drug Des] 2019 Sep; Vol. 94 (5), pp. 1944-1955. Date of Electronic Publication: 2019 Sep 25.Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101262549 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Synthesis and Biological Activity of Sterol 14α-Demethylase and Sterol C24-Methyltransferase Inhibitors.

  • Authors : Leaver DJ; Department of Biology, Geology and Physical Sciences, Sul Ross State University, Alpine, TX 79832, USA. .

Subjects: 14-alpha Demethylase Inhibitors*/14-alpha Demethylase Inhibitors*/14-alpha Demethylase Inhibitors*/chemical synthesis ; 14-alpha Demethylase Inhibitors*/14-alpha Demethylase Inhibitors*/14-alpha Demethylase Inhibitors*/chemistry ; 14-alpha Demethylase Inhibitors*/14-alpha Demethylase Inhibitors*/14-alpha Demethylase Inhibitors*/therapeutic use

  • Source: Molecules (Basel, Switzerland) [Molecules] 2018 Jul 17; Vol. 23 (7). Date of Electronic Publication: 2018 Jul 17.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049

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Homology model, molecular dynamics simulation and novel pyrazole analogs design of Candida albicans CYP450 lanosterol 14 α-demethylase, a target enzyme for antifungal therapy.

  • Authors : Jacob K S; a Department of Pharmaceutical Sciences and Technology , Birla Institute of Technology, Mesra , Ranchi , Jharkhand 835215 , India.; Ganguly S

Subjects: 14-alpha Demethylase Inhibitors/14-alpha Demethylase Inhibitors/14-alpha Demethylase Inhibitors/*chemistry ; Antifungal Agents/Antifungal Agents/Antifungal Agents/*chemistry ; Candida albicans/Candida albicans/Candida albicans/*enzymology

  • Source: Journal of biomolecular structure & dynamics [J Biomol Struct Dyn] 2017 May; Vol. 35 (7), pp. 1446-1463. Date of Electronic Publication: 2016 Aug 02.Publisher: Taylor & Francis Country of Publication: England NLM ID: 8404176 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

The Investigational Fungal Cyp51 Inhibitor VT-1129 Demonstrates Potent In Vitro Activity against Cryptococcus neoformans and Cryptococcus gattii.

  • Authors : Lockhart SR; Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.; Fothergill AW

Subjects: 14-alpha Demethylase Inhibitors/14-alpha Demethylase Inhibitors/14-alpha Demethylase Inhibitors/*pharmacology ; Antifungal Agents/Antifungal Agents/Antifungal Agents/*pharmacology ; Drugs, Investigational/Drugs, Investigational/Drugs, Investigational/*pharmacology

  • Source: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2016 Mar 25; Vol. 60 (4), pp. 2528-31. Date of Electronic Publication: 2016 Mar 25 (Print Publication: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 0315061 Publication Model: Electronic-Print Cited Medium:

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Academic Journal

In silico and in vitro screening to identify structurally diverse non-azole CYP51 inhibitors as potent antifungal agent.

  • Authors : Singh A; Department of Pharmacy, Banasthali University, P.O. Banasthali, Rajasthan 304022, India.; Paliwal SK

Subjects: Molecular Docking Simulation*; 14-alpha Demethylase Inhibitors/14-alpha Demethylase Inhibitors/14-alpha Demethylase Inhibitors/*chemistry ; Antifungal Agents/Antifungal Agents/Antifungal Agents/*chemistry

  • Source: Journal of molecular graphics & modelling [J Mol Graph Model] 2016 Jan; Vol. 63, pp. 1-7. Date of Electronic Publication: 2015 Oct 31.Publisher: Elsevier Science, Inc Country of Publication: United States NLM ID: 9716237 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

The clinical candidate VT-1161 is a highly potent inhibitor of Candida albicans CYP51 but fails to bind the human enzyme.

  • Authors : Warrilow AG; Centre for Cytochrome P450 Biodiversity, Institute of Life Science, College of Medicine, Swansea University, Swansea, Wales, United Kingdom.; Hull CM

Subjects: 14-alpha Demethylase Inhibitors/14-alpha Demethylase Inhibitors/14-alpha Demethylase Inhibitors/*chemistry ; Antifungal Agents/Antifungal Agents/Antifungal Agents/*chemistry ; Candida albicans/Candida albicans/Candida albicans/*chemistry

  • Source: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2014 Dec; Vol. 58 (12), pp. 7121-7. Date of Electronic Publication: 2014 Sep 15.Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 0315061 Publication Model: Print-Electronic Cited Medium:

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Academic Journal

Homology modeling and screening of new 14α-demethylase inhibitor (DMI) fungicides based on optimized expression of CYP51 from Ustilago maydis in Escherichia coli.

  • Authors : Han R; Hubei Key Laboratory of Genetic Regulation and Integrative Biology, College of Life Science, Huazhong Normal University, Wuhan 430079, China.; Zhang J

Subjects: Gene Expression*; 14-alpha Demethylase Inhibitors/14-alpha Demethylase Inhibitors/14-alpha Demethylase Inhibitors/*chemistry ; Fungal Proteins/Fungal Proteins/Fungal Proteins/*metabolism

  • Source: Journal of agricultural and food chemistry [J Agric Food Chem] 2010 Dec 22; Vol. 58 (24), pp. 12810-6. Date of Electronic Publication: 2010 Nov 23.Publisher: American Chemical Society Country of Publication: United States NLM ID: 0374755 Publication Model: Print-Electronic Cited Medium: Internet

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  • 1-10 of  13 results for ""14-alpha Demethylase Inhibitors""