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Reports Outline CCN Intercellular Signaling Proteins Findings from Department of Pediatrics (Is there any relation between connective tissue growth factor and scar tissue in vesicoureteral reflux?)

• Source: Health & Medicine Week. October 25, 2019, 328

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Study Results from Southeast University School of Medicine Broaden Understanding of CCN Intercellular Signaling Proteins (Connective Tissue Growth Factor and Renal Fibrosis)

• Source: Health & Medicine Week. August 30, 2019, 7329

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Investigators at University of Oslo Detail Findings in CCN Intercellular Signaling Proteins [Connective tissue growth factor (CCN2) is a matricellular preproprotein controlled by proteolytic activation]

• Source: Clinical Trials Week. December 10, 2018, 427

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Matricellular Protein CCN5 Reverses Established Cardiac Fibrosis.

• Authors : Jeong, Dongtak¹; Lee, Min-Ah²; Li, Yan²

Subjects: *CCN intercellular signaling proteins; *HEART fibrosis; *HEART failure patients

• Source: Journal of the American College of Cardiology (JACC). Apr2016, Vol. 67 Issue 13, p1556-1568. 13p.

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Extracellular SPARC cooperates with TGF-β signalling to induce pro-fibrotic activation of systemic sclerosis patient dermal fibroblasts.

• Authors : Carvalheiro, Tiago; Fernández, Beatriz Malvar; Ottria, Andrea

Subjects: PROTEIN metabolism; CELLULAR signal transduction; EXTRACELLULAR space

• Source: Rheumatology; Sep2020, Vol. 59 Issue 9, p2258-2263, 6p

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Inhibition of the angiotensin-converting enzyme decreases skeletal muscle fibrosis in dystrophic mice by a diminution in the expression and activity of connective tissue growth factor (CTGF/CCN-2).

• Authors : Morales, María; Cabrera, Daniel; Céspedes, Carlos

Subjects: ANGIOTENSIN converting enzyme; SKELETAL muscle physiology; FIBROSIS

• Source: Cell & Tissue Research; Jul2013, Vol. 353 Issue 1, p173-187, 15p, 2 Color Photographs, 1 Diagram, 6 Graphs

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Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets.

• Authors : Jun, Joon-Il; Lau, Lester F.

Subjects: EXTRACELLULAR matrix; PROTEINS; BIOMOLECULES

• Source: Nature Reviews Drug Discovery; Dec2011, Vol. 10 Issue 12, p945-963, 19p, 5 Diagrams, 5 Charts

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Mechanism of fibrogenesis in submandibular glands in patients with IgG4-RD.

• Authors : Yajima R; Department of Otolaryngology, Sapporo Medical University School of Medicine, Sapporo, 060-8556, Japan.; Department of Cell Science, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, South-1, West-17, Chuo-ku, Sapporo, 060-8556, Japan.

Subjects: Fibroblasts/Fibroblasts/Fibroblasts/*metabolism ; Fibrosis/Fibrosis/Fibrosis/*etiology ; Immunoglobulin G/Immunoglobulin G/Immunoglobulin G/*metabolism

• Source: Journal of molecular histology [J Mol Histol] 2018 Dec; Vol. 49 (6), pp. 577-587. Date of Electronic Publication: 2018 Sep 24.Publisher: Springer Netherlands Country of Publication: Netherlands NLM ID: 101193653 Publication Model: Print-Electronic Cited Medium: Internet

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Study Results from McMaster University Broaden Understanding of Lung Diseases and Conditions (Therapeutic Strategies To Target Connective Tissue Growth Factor In Fibrotic Lung Diseases).

Subjects: CONNECTIVE tissue growth factor; FIBROSIS; LUNG diseases

• Source: Respiratory Therapeutics Week; 2/12/2024, p2769-2769, 1p

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Research on Glaucoma Reported by a Researcher at University Teknologi MARA (Connective tissue growth factor: Role in trabecular meshwork remodeling and intraocular pressure lowering).

Subjects: CONNECTIVE tissue growth factor; INTRAOCULAR pressure; TRANSFORMING growth factors-beta

• Source: Drug Week; 11/17/2023, p2172-2172, 1p

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