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Academic Journal

Discovery of 4-(Arylethynyl)piperidine Derivatives as Potent Nonsaccharide O -GlcNAcase Inhibitors for the Treatment of Alzheimer's Disease.

  • Authors : Cheng Z; Beijing Key Laboratory of Active Substances Discovery and Druggability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.; Shang N

Subjects: Alzheimer Disease*/Alzheimer Disease*/Alzheimer Disease*/drug therapy ; Piperidines*/Piperidines*/Piperidines*/pharmacology ; Piperidines*/Piperidines*/Piperidines*/therapeutic use

  • Source: Journal of medicinal chemistry [J Med Chem] 2024 Aug 22; Vol. 67 (16), pp. 14292-14312. Date of Electronic Publication: 2024 Aug 07.Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Synthesis, Spectroscopic Analysis, and in Vitro/in Silico Biological Studies of Novel Piperidine Derivatives Heterocyclic Schiff-Mannich Base Compounds.

  • Authors : Boy S; Atatürk Vocational College of Health Service, Kafkas University, Kars, 36100, Turkey.; Aras A

Subjects: Enzyme Inhibitors/Enzyme Inhibitors/Enzyme Inhibitors/*pharmacology ; Glutathione Transferase/Glutathione Transferase/Glutathione Transferase/*antagonists & inhibitors ; Heterocyclic Compounds/Heterocyclic Compounds/Heterocyclic Compounds/*pharmacology

  • Source: Chemistry & biodiversity [Chem Biodivers] 2021 Dec; Vol. 18 (12), pp. e2100433. Date of Electronic Publication: 2021 Oct 20.Publisher: Verlag Helvetica Chimica Acta Country of Publication: Switzerland NLM ID: 101197449 Publication Model: Print-Electronic Cited Medium:

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Academic Journal

Inhibition of Plasmodium falciparum Lysyl-tRNA Synthetase via a Piperidine-Ring Scaffold Inspired Cladosporin Analogues.

  • Authors : Babbar P; Molecular Medicine - Structural Parasitology Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), Aruna Asaf Ali Marg, New Delhi, 110067, India.; Department of Medical Elementology and Toxicology, School of Chemical and Life Sciences, Jamia Hamdard, New Delhi, 110062, India.

Subjects: Plasmodium falciparum*/Plasmodium falciparum*/Plasmodium falciparum*/enzymology ; Plasmodium falciparum*/Plasmodium falciparum*/Plasmodium falciparum*/drug effects ; Lysine-tRNA Ligase*/Lysine-tRNA Ligase*/Lysine-tRNA Ligase*/antagonists & inhibitors

  • Source: Chembiochem : a European journal of chemical biology [Chembiochem] 2021 Jul 15; Vol. 22 (14), pp. 2468-2477. Date of Electronic Publication: 2021 May 28.Publisher: Wiley-VCH Verlag Country of Publication: Germany NLM ID: 100937360 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Piperidine scaffold as the novel P2-ligands in cyclopropyl-containing HIV-1 protease inhibitors: Structure-based design, synthesis, biological evaluation and docking study.

  • Authors : Zhou H; Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.; Zhu M

Subjects: Enzyme Inhibitors/Enzyme Inhibitors/Enzyme Inhibitors/*chemistry ; HIV Infections/HIV Infections/HIV Infections/*drug therapy ; HIV Protease Inhibitors/HIV Protease Inhibitors/HIV Protease Inhibitors/*chemistry

  • Source: PloS one [PLoS One] 2020 Jul 22; Vol. 15 (7), pp. e0235483. Date of Electronic Publication: 2020 Jul 22 (Print Publication: 2020).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet

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Academic Journal

Discovery of Aryl Formyl Piperidine Derivatives as Potent, Reversible, and Selective Monoacylglycerol Lipase Inhibitors.

  • Authors : Zhi Z; Jiangsu Key Laboratory of Drug Design and Optimization, Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China.; Zhang W

Subjects: Enzyme Inhibitors/Enzyme Inhibitors/Enzyme Inhibitors/*chemistry ; Monoacylglycerol Lipases/Monoacylglycerol Lipases/Monoacylglycerol Lipases/*antagonists & inhibitors ; Piperidines/Piperidines/Piperidines/*chemistry

  • Source: Journal of medicinal chemistry [J Med Chem] 2020 Jun 11; Vol. 63 (11), pp. 5783-5796. Date of Electronic Publication: 2020 May 29.Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Piperidine and piperazine inhibitors of fatty acid amide hydrolase targeting excitotoxic pathology.

  • Authors : Lamani M; Center for Drug Discovery and Department of Chemistry and Chemical Biology and Pharmaceutical Sciences, Northeastern University, Boston, MA 02155, USA.; Malamas MS

Subjects: Amidohydrolases/Amidohydrolases/Amidohydrolases/*antagonists & inhibitors ; Enzyme Inhibitors/Enzyme Inhibitors/Enzyme Inhibitors/*pharmacology ; Neuroprotective Agents/Neuroprotective Agents/Neuroprotective Agents/*pharmacology

  • Source: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2019 Dec 01; Vol. 27 (23), pp. 115096. Date of Electronic Publication: 2019 Sep 10.Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Characterization of Novel Piperidine-Based Inhibitor of Cathepsin B-Dependent Bacterial Toxins and Viruses.

  • Authors : Hartmann S; School of Applied Life Sciences , Keck Graduate Institute , 535 Watson Drive , Claremont , California 91711 , United States.; Lopez Cruz R

Subjects: Antidotes/Antidotes/Antidotes/*pharmacology ; Antiviral Agents/Antiviral Agents/Antiviral Agents/*pharmacology ; Cathepsin B/Cathepsin B/Cathepsin B/*antagonists & inhibitors

  • Source: ACS infectious diseases [ACS Infect Dis] 2018 Aug 10; Vol. 4 (8), pp. 1235-1245. Date of Electronic Publication: 2018 May 18.Publisher: ACS Publications Country of Publication: United States NLM ID: 101654580 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Novel piperidine-derived amide sEH inhibitors as mediators of lipid metabolism with improved stability.

  • Authors : Pecic S; Department of Medicine, Columbia University, 650 W 168th Street, BB1029, New York, NY 10032, USA. Electronic address: .; Zeki AA

Subjects: Amides*/Amides*/Amides*/chemistry ; Amides*/Amides*/Amides*/pharmacology ; Enzyme Inhibitors*/Enzyme Inhibitors*/Enzyme Inhibitors*/chemistry

  • Source: Prostaglandins & other lipid mediators [Prostaglandins Other Lipid Mediat] 2018 May; Vol. 136, pp. 90-95. Date of Electronic Publication: 2018 Mar 20.Publisher: Elsevier Science Country of Publication: United States NLM ID: 9808648 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Azetidine and Piperidine Carbamates as Efficient, Covalent Inhibitors of Monoacylglycerol Lipase.

  • Authors : Butler CR; Pfizer Worldwide Research and Development , 1 Portland Street, Cambridge, Massachusetts 02139, United States.; Beck EM

Subjects: Azetidines/Azetidines/Azetidines/*pharmacology ; Carbamates/Carbamates/Carbamates/*pharmacology ; Enzyme Inhibitors/Enzyme Inhibitors/Enzyme Inhibitors/*pharmacology

  • Source: Journal of medicinal chemistry [J Med Chem] 2017 Dec 14; Vol. 60 (23), pp. 9860-9873. Date of Electronic Publication: 2017 Dec 05.Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Chemical exploration of 4-(4-fluorobenzyl)piperidine fragment for the development of new tyrosinase inhibitors.

  • Authors : Ferro S; Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche e Ambientali (CHIBIOFARAM) Polo Universitario SS. Annunziata, Università di Messina, Viale Annunziata I-98168 Messina, Italy. Electronic address: .; De Luca L

Subjects: Enzyme Inhibitors/Enzyme Inhibitors/Enzyme Inhibitors/*chemistry ; Monophenol Monooxygenase/Monophenol Monooxygenase/Monophenol Monooxygenase/*antagonists & inhibitors ; Piperidines/Piperidines/Piperidines/*chemistry

  • Source: European journal of medicinal chemistry [Eur J Med Chem] 2017 Jan 05; Vol. 125, pp. 992-1001. Date of Electronic Publication: 2016 Oct 18.Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet

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  • 1-10 of  1,331 results for ""PIPERIDINE""