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Academic Journal

Depleting chemoresponsive mitochondrial fission mediator DRP1 does not mitigate sarcoma resistance.

  • Authors : Borankova K; Department of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic.; International Clinical Research Center, St. Anne's University Hospital, Brno, Czech Republic.

Subjects: Mitochondrial Dynamics*/Mitochondrial Dynamics*/Mitochondrial Dynamics*/drug effects ; Dynamins*/Dynamins*/Dynamins*/metabolism ; Dynamins*/Dynamins*/Dynamins*/genetics

  • Source: Life science alliance [Life Sci Alliance] 2024 Dec 06; Vol. 8 (2). Date of Electronic Publication: 2024 Dec 06 (Print Publication: 2025).Publisher: Life Science Alliance, LLC Country of Publication: United States NLM ID: 101728869 Publication Model: Electronic-Print Cited Medium: Internet

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Academic Journal

Mutation-Specific CRISPR Targeting with SaCas9 and AsCas12a Restores Therapeutic Sensitivity in Treatment-Resistant Melanoma.

Subjects: Melanoma*/Melanoma*/Melanoma*/genetics ; Melanoma*/Melanoma*/Melanoma*/drug therapy ; Melanoma*/Melanoma*/Melanoma*/therapy

  • Source: The CRISPR journal [CRISPR J] 2024 Dec; Vol. 7 (6), pp. 366-373. Date of Electronic Publication: 2024 Oct 10.Publisher: Mary Ann Liebert, Inc Country of Publication: United States NLM ID: 101738191 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Tracking Response and Resistance in Acute Myeloid Leukemia through Single-Cell DNA Sequencing Helps Uncover New Therapeutic Targets.

  • Authors : Bruno S; Department of Medical and Surgical Science (DIMEC), University of Bologna, 40138 Bologna, Italy.; Borsi E

Subjects: Leukemia, Myeloid, Acute*/Leukemia, Myeloid, Acute*/Leukemia, Myeloid, Acute*/genetics ; Leukemia, Myeloid, Acute*/Leukemia, Myeloid, Acute*/Leukemia, Myeloid, Acute*/drug therapy ; Drug Resistance, Neoplasm*/Drug Resistance, Neoplasm*/Drug Resistance, Neoplasm*/genetics

  • Source: International journal of molecular sciences [Int J Mol Sci] 2024 Sep 17; Vol. 25 (18). Date of Electronic Publication: 2024 Sep 17.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

Silencing MFN2 Drives WNT/β-catenin Nucleation to Reduce Sorafenib Sensitivity in Hepatocellular Carcinoma Cells.

  • Authors : Zeng CM; Department of Geriatric Medicine, Shengli Clinical Medical College of Fujian Medical University, Fujian Key Laboratory of Geriatrics Diseases, Fujian Provincial Center for Geriatrics, Fujian Provincial Hospital, Fuzhou, 350001, China.; Shao B

Subjects: Sorafenib*/Sorafenib*/Sorafenib*/pharmacology ; Carcinoma, Hepatocellular*/Carcinoma, Hepatocellular*/Carcinoma, Hepatocellular*/genetics ; Carcinoma, Hepatocellular*/Carcinoma, Hepatocellular*/Carcinoma, Hepatocellular*/drug therapy

  • Source: Current medical science [Curr Med Sci] 2024 Aug; Vol. 44 (4), pp. 789-798. Date of Electronic Publication: 2024 Jun 27.Publisher: Huazhong University of Science and Technology Country of Publication: China NLM ID: 101729993 Publication Model: Print-Electronic Cited Medium:

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Academic Journal

Inhibition of MFN1 restores tamoxifen-induced apoptosis in resistant cells by disrupting aberrant mitochondrial fusion dynamics.

  • Authors : Song Y; The State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, No.6 Ankang Avenue, Guian New District, Guizhou 561113, China; The High Efficacy Application of Natural Medicinal Resources Engineering Center of Guizhou Province, School of Pharmaceutical Sciences, Guizhou Medical University, No.6 Ankang Avenue, Guian New District, Guizhou 561113, China

Subjects: Tamoxifen*/Tamoxifen*/Tamoxifen*/pharmacology ; Mitochondrial Dynamics*/Mitochondrial Dynamics*/Mitochondrial Dynamics*/drug effects ; Apoptosis*/Apoptosis*/Apoptosis*/drug effects

  • Source: Cancer letters [Cancer Lett] 2024 May 28; Vol. 590, pp. 216847. Date of Electronic Publication: 2024 Apr 05.Publisher: Elsevier Science Ireland Country of Publication: Ireland NLM ID: 7600053 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

CircRNA_0044556 diminishes the sensitivity of triple‑negative breast cancer cells to adriamycin by sponging miR‑145 and regulating NRAS.

  • Authors : Chen J; The Second Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin 300060, P.R. China.; Shi P

Subjects: Doxorubicin/Doxorubicin/Doxorubicin/*pharmacology ; Drug Resistance, Neoplasm/Drug Resistance, Neoplasm/Drug Resistance, Neoplasm/*genetics ; GTP Phosphohydrolases/GTP Phosphohydrolases/GTP Phosphohydrolases/*genetics

  • Source: Molecular medicine reports [Mol Med Rep] 2022 Feb; Vol. 25 (2). Date of Electronic Publication: 2021 Dec 16.Publisher: D. A. Spandidos Country of Publication: Greece NLM ID: 101475259 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Diverse alterations associated with resistance to KRAS(G12C) inhibition.

  • Authors : Zhao Y; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer, New York, NY, USA.; Murciano-Goroff YR

Subjects: Mutation*; Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*pharmacology ; Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*therapeutic use

  • Source: Nature [Nature] 2021 Nov; Vol. 599 (7886), pp. 679-683. Date of Electronic Publication: 2021 Nov 10.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

miR-145-5p Modulates Gefitinib Resistance by Targeting NRAS and MEST in Non-Small Cell Lung Cancer.

  • Authors : Yu C; Department of Urology, The Third Medical Center of Chinese People's Liberation Army General Hospital, Beijing, China.; Li B

Subjects: Carcinoma, Non-Small-Cell Lung/Carcinoma, Non-Small-Cell Lung/Carcinoma, Non-Small-Cell Lung/*drug therapy ; Drug Resistance, Neoplasm/Drug Resistance, Neoplasm/Drug Resistance, Neoplasm/*genetics ; Gefitinib/Gefitinib/Gefitinib/*pharmacology

  • Source: Annals of clinical and laboratory science [Ann Clin Lab Sci] 2021 Sep; Vol. 51 (5), pp. 625-637.Publisher: Institute for Clinical Science Country of Publication: United States NLM ID: 0410247 Publication Model: Print Cited Medium: Internet ISSN:

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Academic Journal

TRERNA1 upregulation mediated by HBx promotes sorafenib resistance and cell proliferation in HCC via targeting NRAS by sponging miR-22-3p.

  • Authors : Song W; Department of Medical Genetics and Developmental Biology, Medical School of Southeast University, The Key Laboratory of Developmental Genes and Human Diseases, Ministry of Education, Southeast University, Nanjing 210009, China; School of Life Science, Southeast University, Nanjing 210018, China

Subjects: Drug Resistance, Neoplasm*; Carcinoma, Hepatocellular/Carcinoma, Hepatocellular/Carcinoma, Hepatocellular/*pathology ; GTP Phosphohydrolases/GTP Phosphohydrolases/GTP Phosphohydrolases/*genetics

  • Source: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2021 Aug 04; Vol. 29 (8), pp. 2601-2616. Date of Electronic Publication: 2021 Apr 09.Publisher: Cell Press Country of Publication: United States NLM ID: 100890581 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Analysis of nonleukemic cellular subcompartments reconstructs clonal evolution of acute myeloid leukemia and identifies therapy-resistant preleukemic clones.

  • Authors : Saeed BR; Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany.; Manta L

Subjects: Drug Resistance, Neoplasm* ; Point Mutation*; Biomarkers, Tumor/Biomarkers, Tumor/Biomarkers, Tumor/*genetics

  • Source: International journal of cancer [Int J Cancer] 2021 Jun 01; Vol. 148 (11), pp. 2825-2838. Date of Electronic Publication: 2021 Jan 18.Publisher: Wiley-Liss Country of Publication: United States NLM ID: 0042124 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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  • 1-10 of  53 results for ""GTP Phosphohydrolases genetics""