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Academic Journal

Discovery of small molecules for autophagy-lysosome degradation of immune checkpoint proteins.

  • Authors : Wang K; Department of Biomedical Engineering and Diagnostic Pharmacy, School of Engineering, China Pharmaceutical University, Nanjing, 210009, China.; Qi Z

Subjects: Autophagy*/Autophagy*/Autophagy*/drug effects ; Drug Discovery* ; Lysosomes*/Lysosomes*/Lysosomes*/metabolism

  • Source: European journal of medicinal chemistry [Eur J Med Chem] 2024 Dec 15; Vol. 280, pp. 116958. Date of Electronic Publication: 2024 Oct 16.Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Challenges and Prospects of DNA-Encoded Library Data Interpretation.

  • Authors : Wichert M; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, 4070 Basel, Switzerland.; Guasch L

Subjects: DNA*/DNA*/DNA*/chemistry ; Drug Discovery*/Drug Discovery*/Drug Discovery*/methods ; Small Molecule Libraries*/Small Molecule Libraries*/Small Molecule Libraries*/chemistry

  • Source: Chemical reviews [Chem Rev] 2024 Nov 27; Vol. 124 (22), pp. 12551-12572. Date of Electronic Publication: 2024 Nov 07.Publisher: American Chemical Society Country of Publication: United States NLM ID: 2985134R Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Identification of protein partners for small molecules reshapes the understanding of nonalcoholic steatohepatitis and drug discovery.

  • Authors : Wang D; School of Exercise and Health, Shanghai University of Sport, Shanghai 200438, China.; Wang Y

Subjects: Drug Discovery* ; Fatty Liver*/Fatty Liver*/Fatty Liver*/metabolism ; Proteolysis Targeting Chimera*/Proteolysis Targeting Chimera*/Proteolysis Targeting Chimera*/chemistry

  • Source: Life sciences [Life Sci] 2024 Nov 01; Vol. 356, pp. 123031. Date of Electronic Publication: 2024 Sep 01.Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0375521 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Enhancing the Predictive Power of Machine Learning Models through a Chemical Space Complementary DEL Screening Strategy.

  • Authors : Suo Y; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Zhang Jiang Hi-Tech Park, Pudong, Shanghai 201203, China.; University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, China.

Subjects: Machine Learning* ; Small Molecule Libraries*/Small Molecule Libraries*/Small Molecule Libraries*/chemistry ; Transcription Factors*/Transcription Factors*/Transcription Factors*/metabolism

  • Source: Journal of medicinal chemistry [J Med Chem] 2024 Nov 14; Vol. 67 (21), pp. 18969-18980. Date of Electronic Publication: 2024 Oct 23.Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Perspectives on current approaches to virtual screening in drug discovery.

Subjects: Drug Discovery*/Drug Discovery*/Drug Discovery*/methods ; Machine Learning* ; Small Molecule Libraries*

  • Source: Expert opinion on drug discovery [Expert Opin Drug Discov] 2024 Oct; Vol. 19 (10), pp. 1173-1183. Date of Electronic Publication: 2024 Aug 12.Publisher: Taylor & Francis Country of Publication: England NLM ID: 101295755 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Computational Toxicology Methods in Chemical Library Design and High-Throughput Screening Hit Validation.

  • Authors : Kauler KR; Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN, USA.; Hevener KE

Subjects: High-Throughput Screening Assays*/High-Throughput Screening Assays*/High-Throughput Screening Assays*/methods ; Small Molecule Libraries*/Small Molecule Libraries*/Small Molecule Libraries*/toxicity ; Drug Discovery*/Drug Discovery*/Drug Discovery*/methods

  • Source: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2025; Vol. 2834, pp. 181-193.Publisher: Humana Press Country of Publication: United States NLM ID: 9214969 Publication Model: Print Cited Medium: Internet ISSN: 1940-6029

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Academic Journal

RNA-Binding Small Molecules in Drug Discovery and Delivery: An Overview from Fundamentals.

  • Authors : Chen S; Department of Pharmaceutical Engineering, School of Pharmaceutical Sciences, Wuhan University, Wuhan, Hubei 430071, China.; Department of Pharmacy, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, China.

Subjects: Drug Discovery* ; Small Molecule Libraries*/Small Molecule Libraries*/Small Molecule Libraries*/chemistry ; Small Molecule Libraries*/Small Molecule Libraries*/Small Molecule Libraries*/pharmacology

  • Source: Journal of medicinal chemistry [J Med Chem] 2024 Sep 26; Vol. 67 (18), pp. 16002-16017. Date of Electronic Publication: 2024 Sep 17.Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Large library docking identifies positive allosteric modulators of the calcium-sensing receptor.

  • Authors : Liu F; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94143, USA.; Wu CG

Subjects: Cryoelectron Microscopy* ; Molecular Docking Simulation* ; Parathyroid Hormone*/Parathyroid Hormone*/Parathyroid Hormone*/metabolism

  • Source: Science (New York, N.Y.) [Science] 2024 Sep 20; Vol. 385 (6715), pp. eado1868. Date of Electronic Publication: 2024 Sep 20.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic

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Academic Journal

Ligand discovery by activity-based protein profiling.

  • Authors : Niphakis MJ; Lundbeck La Jolla Research Center Inc., San Diego, CA, USA. Electronic address: .; Cravatt BF

Subjects: Drug Discovery* ; Proteins*/Proteins*/Proteins*/metabolism ; Proteins*/Proteins*/Proteins*/chemistry

  • Source: Cell chemical biology [Cell Chem Biol] 2024 Sep 19; Vol. 31 (9), pp. 1636-1651.Publisher: Cell Press Country of Publication: United States NLM ID: 101676030 Publication Model: Print Cited Medium: Internet ISSN: 2451-9448

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Academic Journal

Discovery Small-Molecule p300 Inhibitors Derived from a Newly Developed Indazolone-Focused DNA-Encoded Library.

  • Authors : Suo Y; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai 201203, China.; University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, China.

Subjects: DNA*/DNA*/DNA*/chemistry ; Indazoles*/Indazoles*/Indazoles*/chemistry ; Indazoles*/Indazoles*/Indazoles*/pharmacology

  • Source: Bioconjugate chemistry [Bioconjug Chem] 2024 Aug 21; Vol. 35 (8), pp. 1251-1257. Date of Electronic Publication: 2024 Aug 08.Publisher: American Chemical Society Country of Publication: United States NLM ID: 9010319 Publication Model: Print-Electronic Cited Medium: Internet

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  • 1-10 of  1,629 results for ""Small Molecule Libraries""