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Academic Journal

Hydrophobic tagging of small molecules: an overview of the literature and future outlook.

  • Authors : Zhou Y; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan, PR China.; Zhou F

Subjects: Hydrophobic and Hydrophilic Interactions* ; Drug Design*/Drug Design*/Drug Design*/methods ; Small Molecule Libraries*/Small Molecule Libraries*/Small Molecule Libraries*/pharmacology

  • Source: Expert opinion on drug discovery [Expert Opin Drug Discov] 2024 Jul; Vol. 19 (7), pp. 799-813. Date of Electronic Publication: 2024 Jun 02.Publisher: Taylor & Francis Country of Publication: England NLM ID: 101295755 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Strategies in the design and development of (TAR) DNA-binding protein 43 (TDP-43) binding ligands.

  • Authors : Rao PPN; School of Pharmacy, Health Sciences Campus, University of Waterloo, 200 University Avenue West, Waterloo, Ontario, N2L 3G1, Canada. Electronic address: .; Shakeri A

Subjects: Drug Development*; DNA-Binding Proteins/DNA-Binding Proteins/DNA-Binding Proteins/*antagonists & inhibitors ; Oligonucleotides/Oligonucleotides/Oligonucleotides/*pharmacology

  • Source: European journal of medicinal chemistry [Eur J Med Chem] 2021 Dec 05; Vol. 225, pp. 113753. Date of Electronic Publication: 2021 Aug 08.Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Developments of CRBN-based PROTACs as potential therapeutic agents.

  • Authors : Wang C; The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao Cancer Institute, Qingdao, 266071, Shandong, China. Electronic address: .; Zhang Y

Subjects: Drug Development*; Enzyme Inhibitors/Enzyme Inhibitors/Enzyme Inhibitors/*pharmacology ; Neoplasms/Neoplasms/Neoplasms/*drug therapy

  • Source: European journal of medicinal chemistry [Eur J Med Chem] 2021 Dec 05; Vol. 225, pp. 113749. Date of Electronic Publication: 2021 Aug 10.Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Development of photocontrolled BRD4 PROTACs for tongue squamous cell carcinoma (TSCC).

  • Authors : Li Z; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (MOE), School of Pharmacy, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China.; Ma S

Subjects: Drug Development*; Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*pharmacology ; Carcinoma, Squamous Cell/Carcinoma, Squamous Cell/Carcinoma, Squamous Cell/*drug therapy

  • Source: European journal of medicinal chemistry [Eur J Med Chem] 2021 Oct 15; Vol. 222, pp. 113608. Date of Electronic Publication: 2021 Jun 05.Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Progress in the development of small molecular inhibitors of the Bruton's tyrosine kinase (BTK) as a promising cancer therapy.

  • Authors : Liu XJ; School of Pharmaceutical Sciences, Institute of Drug Discovery & Development, Key Laboratory of Advanced Drug Preparation Technologies (Ministry of Education), Zhengzhou University, Zhengzhou 450001, China.; Xu-Liu

Subjects: Drug Development*; Agammaglobulinaemia Tyrosine Kinase/Agammaglobulinaemia Tyrosine Kinase/Agammaglobulinaemia Tyrosine Kinase/*antagonists & inhibitors ; Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*pharmacology

  • Source: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2021 Oct 01; Vol. 47, pp. 116358. Date of Electronic Publication: 2021 Aug 10.Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Recent Update on Development of Small-Molecule STAT3 Inhibitors for Cancer Therapy: From Phosphorylation Inhibition to Protein Degradation.

  • Authors : Dong J; Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou, Zhejiang 310022, China.; Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou, Zhejiang 310018, China.

Subjects: Drug Development*; Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*pharmacology ; Neoplasms/Neoplasms/Neoplasms/*drug therapy

  • Source: Journal of medicinal chemistry [J Med Chem] 2021 Jul 08; Vol. 64 (13), pp. 8884-8915. Date of Electronic Publication: 2021 Jun 25.Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Developments of small molecules as inhibitors for carbonic anhydrase isoforms.

  • Authors : Buabeng ER; Department of Chemistry, 100 Piedmont Avenue SE, Georgia State University, Atlanta, GA 30303, USA; Center for Diagnostics and Therapeutics, 100 Piedmont Avenue SE, Georgia State University, Atlanta, GA 30303, USA.

Subjects: Drug Development*; Carbonic Anhydrase Inhibitors/Carbonic Anhydrase Inhibitors/Carbonic Anhydrase Inhibitors/*chemical synthesis ; Carbonic Anhydrase Inhibitors/Carbonic Anhydrase Inhibitors/Carbonic Anhydrase Inhibitors/*pharmacology

  • Source: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2021 Jun 01; Vol. 39, pp. 116140. Date of Electronic Publication: 2021 Apr 16.Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Emerging small-molecule inhibitors of the Bruton's tyrosine kinase (BTK): Current development.

  • Authors : Liu J; Pharmaceutical Department, PLA Strategic Support Force Medical Center, No.9 Anxiangbeili Road, Chaoyang District, Beijing, 100101, PR China.; Chen C

Subjects: Drug Development*; Agammaglobulinaemia Tyrosine Kinase/Agammaglobulinaemia Tyrosine Kinase/Agammaglobulinaemia Tyrosine Kinase/*antagonists & inhibitors ; Protein Kinase Inhibitors/Protein Kinase Inhibitors/Protein Kinase Inhibitors/*pharmacology

  • Source: European journal of medicinal chemistry [Eur J Med Chem] 2021 May 05; Vol. 217, pp. 113329. Date of Electronic Publication: 2021 Mar 12.Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Recent advances in the development of small molecules targeting RNA G-quadruplexes for drug discovery.

  • Authors : Tao Y; State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, China; National Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.

Subjects: Drug Development*; RNA/RNA/RNA/*drug effects ; Small Molecule Libraries/Small Molecule Libraries/Small Molecule Libraries/*pharmacology

  • Source: Bioorganic chemistry [Bioorg Chem] 2021 May; Vol. 110, pp. 104804. Date of Electronic Publication: 2021 Mar 06.Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

The development of an Amber-compatible organosilane force field for drug-like small molecules.

  • Authors : Dong X; Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu, 610041, P. R. China. .; Yuan X

Subjects: Drug Development*; Organosilicon Compounds/Organosilicon Compounds/Organosilicon Compounds/*chemistry ; Small Molecule Libraries/Small Molecule Libraries/Small Molecule Libraries/*chemistry

  • Source: Physical chemistry chemical physics : PCCP [Phys Chem Chem Phys] 2021 Jun 09; Vol. 23 (22), pp. 12582-12591.Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 100888160 Publication Model: Print Cited Medium: Internet ISSN:

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  • 1-10 of  102 results for ""Small Molecule Libraries""