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Academic Journal

A Site-Specific Click Chemistry Approach to Di-Ubiquitylate H1 Variants Reveals Position-Dependent Stimulation of the DNA Repair Protein RNF168.

  • Authors : Franz P; Laboratory of Biophysical Chemistry of Macromolecules (LCBM), Institute of Chemical Sciences and Engineering (ISIC), EPFL (Ecole Polytechnique Fédérale de Lausanne), Station 6, 1015, Lausanne, Switzerland.; Delvaux de Fenffe CM

Subjects: Click Chemistry* ; Ubiquitination* ; Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/metabolism

  • Source: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2024 Dec 20; Vol. 63 (52), pp. e202408435. Date of Electronic Publication: 2024 Nov 14.Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 0370543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3773

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Academic Journal

PARP10 promotes the repair of nascent strand DNA gaps through RAD18 mediated translesion synthesis.

  • Authors : Khatib JB; Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA.; Dhoonmoon A

Subjects: Proliferating Cell Nuclear Antigen*/Proliferating Cell Nuclear Antigen*/Proliferating Cell Nuclear Antigen*/metabolism ; Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/metabolism ; Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/genetics

  • Source: Nature communications [Nat Commun] 2024 Jul 23; Vol. 15 (1), pp. 6197. Date of Electronic Publication: 2024 Jul 23.Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

E3 ligases: a ubiquitous link between DNA repair, DNA replication and human disease.

  • Authors : Chauhan AS; Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, U.K.; Jhujh SS

Subjects: Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/metabolism ; Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/genetics ; DNA Repair*

  • Source: The Biochemical journal [Biochem J] 2024 Jul 17; Vol. 481 (14), pp. 923-944.Publisher: Published by Portland Press on behalf of the Biochemical Society Country of Publication: England NLM ID: 2984726R Publication Model: Print Cited

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Academic Journal

Germline BARD1 variants predispose to mesothelioma by impairing DNA repair and calcium signaling.

  • Authors : Novelli F; Thoracic Oncology, University of Hawaii Cancer Center, Honolulu, HI 96816.; Yoshikawa Y

Subjects: DNA Repair*/DNA Repair*/DNA Repair*/genetics ; Tumor Suppressor Proteins*/Tumor Suppressor Proteins*/Tumor Suppressor Proteins*/genetics ; Tumor Suppressor Proteins*/Tumor Suppressor Proteins*/Tumor Suppressor Proteins*/metabolism

  • Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Jul 16; Vol. 121 (29), pp. e2405231121. Date of Electronic Publication: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Ubiquitin-induced RNF168 condensation promotes DNA double-strand break repair.

  • Authors : Feng LL; Department of Pathology, Henan Provincial Key Laboratory of Radiation Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.; Tianjian Laboratory of Advanced Biomedical Sciences, Zhengzhou University, Zhengzhou, Henan 450052, China.

Subjects: DNA Repair* ; Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/metabolism ; Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/genetics

  • Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Jul 09; Vol. 121 (28), pp. e2322972121. Date of Electronic Publication: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

UHRF1 poly-auto-ubiquitination induced by the anti-cancer drug, thymoquinone, is involved in the DNA repair machinery recruitment.

  • Authors : Almalki NAR; Department of Functional Genomics, Institute of Genetics and Molecular and Cellular Biology (IGBMC), INSERM U1258, CNRS UMR 7104, University of Strasbourg, 'équipe labellisée' Ligue contre le Cancer, Illkirch-Graffenstaden 67404, France; Experimental Biochemistry unit, King Fahad medical research Centre, King Abdulaziz University, Jeddah 21589, Saudi Arabia.

Subjects: Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/metabolism ; Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/genetics ; CCAAT-Enhancer-Binding Proteins*/CCAAT-Enhancer-Binding Proteins*/CCAAT-Enhancer-Binding Proteins*/metabolism

  • Source: The international journal of biochemistry & cell biology [Int J Biochem Cell Biol] 2024 Jun; Vol. 171, pp. 106582. Date of Electronic Publication: 2024 Apr 20.Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9508482 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

UBA80 and UBA52 fine-tune RNF168-dependent histone ubiquitination and DNA repair.

  • Authors : Lee SO; Department of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA; Department of Radiation Oncology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.

Subjects: DNA Repair* ; Histones*/Histones*/Histones*/metabolism ; Nucleosomes*/Nucleosomes*/Nucleosomes*/genetics

  • Source: The Journal of biological chemistry [J Biol Chem] 2023 Aug; Vol. 299 (8), pp. 105043. Date of Electronic Publication: 2023 Jul 13.Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication

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Academic Journal

Emerging Roles of RNF168 in Tumor Progression.

  • Authors : Xie T; Jiangsu Key Laboratory of Carcinogenesis and Intervention, School of Life Science and Technology, China Pharmaceutical University, 639 Longmian Road, Nanjing 211198, China.; Qin H

Subjects: DNA Repair* ; Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/metabolism; Humans

  • Source: Molecules (Basel, Switzerland) [Molecules] 2023 Feb 02; Vol. 28 (3). Date of Electronic Publication: 2023 Feb 02.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049

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Academic Journal

RNF126-Mediated MRE11 Ubiquitination Activates the DNA Damage Response and Confers Resistance of Triple-Negative Breast Cancer to Radiotherapy.

  • Authors : Liu W; Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650201, China.; Kunming College of Life Sciences, University of the Chinese Academy of Sciences, Kunming, 650204, China.

Subjects: DNA Damage*/DNA Damage*/DNA Damage*/genetics ; DNA Damage*/DNA Damage*/DNA Damage*/radiation effects ; DNA Repair*/DNA Repair*/DNA Repair*/genetics

  • Source: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2023 Feb; Vol. 10 (5), pp. e2203884. Date of Electronic Publication: 2022 Dec 23.Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844

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Academic Journal

SIAH2 regulates DNA end resection and replication fork recovery by promoting CtIP ubiquitination.

  • Authors : Jeong SY; Laboratory of Genomic Instability and Cancer therapeutics, Chosun University School of Medicine, 309 Pilmun-daero, Dong-gu, Gwangju 61452, Republic of Korea.; Department of Cellular and Molecular Medicine, Chosun University School of Medicine, 309 Pilmun-daero, Dong-gu, Gwangju 61452, Republic of Korea.

Subjects: DNA Repair* ; DNA Replication*; Endodeoxyribonucleases/Endodeoxyribonucleases/Endodeoxyribonucleases/*metabolism

  • Source: Nucleic acids research [Nucleic Acids Res] 2022 Oct 14; Vol. 50 (18), pp. 10469-10486.Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN:

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  • 1-10 of  791 results for ""Ubiquitin-Protein Ligases""