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Academic Journal

Improving dynamic control of toehold-mediated strand displacement reactions through phosphorothioate modifications.

  • Authors : Liang R; School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. .; Shen Y

Subjects: Phosphorothioate Oligonucleotides*/Phosphorothioate Oligonucleotides*/Phosphorothioate Oligonucleotides*/chemistry ; DNA*/DNA*/DNA*/chemistry

  • Source: Nanoscale [Nanoscale] 2024 Dec 12; Vol. 16 (48), pp. 22393-22402. Date of Electronic Publication: 2024 Dec 12.Publisher: RSC Pub Country of Publication: England NLM ID: 101525249 Publication Model: Electronic Cited Medium: Internet ISSN: 2040-3372

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Developing predictive hybridization models for phosphorothioate oligonucleotides using high-resolution melting.

  • Authors : Wang SS; Department of Molecular Biosciences, Center for Systems and Synthetic Biology, College of Natural Sciences, The University of Texas at Austin, Austin, Texas, United States of America.; Xiong E

Subjects: DNA*/DNA*/DNA*/genetics ; Phosphorothioate Oligonucleotides*; Nucleic Acid Conformation

  • Source: PloS one [PLoS One] 2022 May 18; Vol. 17 (5), pp. e0268575. Date of Electronic Publication: 2022 May 18 (Print Publication: 2022).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet

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Academic Journal

Stressing the Role of DNA as a Drug Carrier: Synthesis of DNA-Drug Conjugates through Grafting Chemotherapeutics onto Phosphorothioate Oligonucleotides.

  • Authors : Guo Y; School of Chemistry and Chemical Engineering, State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China.; Zhang J

Subjects: Antineoplastic Agents, Phytogenic/Antineoplastic Agents, Phytogenic/Antineoplastic Agents, Phytogenic/*administration & dosage ; DNA/DNA/DNA/*chemistry ; Drug Carriers/Drug Carriers/Drug Carriers/*chemistry

  • Source: Advanced materials (Deerfield Beach, Fla.) [Adv Mater] 2019 Apr; Vol. 31 (16), pp. e1807533. Date of Electronic Publication: 2019 Mar 07.Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 9885358 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-4095

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Academic Journal

Understanding the effect of controlling phosphorothioate chirality in the DNA gap on the potency and safety of gapmer antisense oligonucleotides.

Subjects: DNA/DNA/DNA/*genetics ; Oligonucleotides, Antisense/Oligonucleotides, Antisense/Oligonucleotides, Antisense/*genetics ; Phosphorothioate Oligonucleotides/Phosphorothioate Oligonucleotides/Phosphorothioate Oligonucleotides/*genetics

  • Source: Nucleic acids research [Nucleic Acids Res] 2020 Feb 28; Vol. 48 (4), pp. 1691-1700.Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN:

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Homopurine R P -stereodefined phosphorothioate analogs of DNA with hampered Watson-Crick base pairings form Hoogsteen paired parallel duplexes with (2'-OMe)-RNAs.

  • Authors : Maciaszek A; Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Department of Bioorganic Chemistry, Sienkiewicza 112, 90-363 Łódź, Poland. .; Jastrzębska K

Subjects: DNA/DNA/DNA/*chemistry ; Phosphorothioate Oligonucleotides/Phosphorothioate Oligonucleotides/Phosphorothioate Oligonucleotides/*chemistry ; RNA/RNA/RNA/*chemistry

  • Source: Organic & biomolecular chemistry [Org Biomol Chem] 2019 May 08; Vol. 17 (18), pp. 4611-4620.Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101154995 Publication Model: Print Cited Medium: Internet ISSN:

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Ultrasensitive nucleic acid detection based on phosphorothioated hairpin-assisted isothermal amplification.

  • Authors : Jung Y; Department of Chemical and Biomolecular Engineering (BK 21+ Program), KAIST, Daehak-ro 291, Yuseong-gu, Daejeon, 34141, Republic of Korea.; Song J

Subjects: Biosensing Techniques/Biosensing Techniques/Biosensing Techniques/*methods ; DNA/DNA/DNA/*blood ; Fluorescent Dyes/Fluorescent Dyes/Fluorescent Dyes/*chemistry

  • Source: Scientific reports [Sci Rep] 2021 Apr 16; Vol. 11 (1), pp. 8399. Date of Electronic Publication: 2021 Apr 16.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Conformation and protein interactions of intramolecular DNA and phosphorothioate four-way junctions.

  • Authors : Troisi M; Department of Chemistry and Biochemistry, University of San Diego, San Diego, CA 92110, USA.; Klein M

Subjects: Nucleic Acid Conformation*; DNA/DNA/DNA/*chemistry ; DNA/DNA/DNA/*metabolism

  • Source: Experimental biology and medicine (Maywood, N.J.) [Exp Biol Med (Maywood)] 2021 Mar; Vol. 246 (6), pp. 707-717. Date of Electronic Publication: 2020 Dec 20.Publisher: Sage Country of Publication: England NLM ID: 100973463 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1535-3699

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Enhanced affinity of racemic phosphorothioate DNA with transcription factor SATB1 arising from diastereomer-specific hydrogen bonds and hydrophobic contacts.

  • Authors : Yamasaki K; Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), 1-1-1 Higashi, Tsukuba 305-8566, Japan.; Akutsu Y

Subjects: DNA/DNA/DNA/*chemistry ; Matrix Attachment Region Binding Proteins/Matrix Attachment Region Binding Proteins/Matrix Attachment Region Binding Proteins/*chemistry ; Phosphorothioate Oligonucleotides/Phosphorothioate Oligonucleotides/Phosphorothioate Oligonucleotides/*chemistry

  • Source: Nucleic acids research [Nucleic Acids Res] 2020 May 07; Vol. 48 (8), pp. 4551-4561.Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN:

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Academic Journal

Oxidation of phosphorothioate DNA modifications leads to lethal genomic instability.

  • Authors : Kellner S; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.; DeMott MS

Subjects: DNA/DNA/DNA/*metabolism ; Genomic Instability/Genomic Instability/Genomic Instability/*drug effects ; Phosphorothioate Oligonucleotides/Phosphorothioate Oligonucleotides/Phosphorothioate Oligonucleotides/*metabolism

  • Source: Nature chemical biology [Nat Chem Biol] 2017 Aug; Vol. 13 (8), pp. 888-894. Date of Electronic Publication: 2017 Jun 12.Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Characterizing the effect of GalNAc and phosphorothioate backbone on binding of antisense oligonucleotides to the asialoglycoprotein receptor.

  • Authors : Schmidt K; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, USA.; Prakash TP

Subjects: Biological Assay*; Acetylgalactosamine/Acetylgalactosamine/Acetylgalactosamine/*chemistry ; Asialoglycoprotein Receptor/Asialoglycoprotein Receptor/Asialoglycoprotein Receptor/*metabolism

  • Source: Nucleic acids research [Nucleic Acids Res] 2017 Mar 17; Vol. 45 (5), pp. 2294-2306.Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN:

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  • 1-10 of  179 results for ""Phosphorothioate Oligonucleotides""