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Academic Journal

Monogenic diabetes: a gateway to precision medicine in diabetes.

  • Authors : Zhang H; University of Maryland School of Medicine, Department of Medicine, Baltimore, Maryland, USA.; Colclough K

Subjects: Diabetes Mellitus*/Diabetes Mellitus*/Diabetes Mellitus*/drug therapy ; Diabetes Mellitus*/Diabetes Mellitus*/Diabetes Mellitus*/genetics ; Diabetes Mellitus*/Diabetes Mellitus*/Diabetes Mellitus*/metabolism

  • Source: The Journal of clinical investigation [J Clin Invest] 2021 Feb 01; Vol. 131 (3).Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: Print Cited Medium:

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Academic Journal

An HNF1α truncation associated with maturity-onset diabetes of the young impairs pancreatic progenitor differentiation by antagonizing HNF1β function.

Subjects: Diabetes Mellitus* ; Induced Pluripotent Stem Cells*; Hepatocyte Nuclear Factor 1-alpha/Hepatocyte Nuclear Factor 1-alpha/Hepatocyte Nuclear Factor 1-alpha/*geneticsMason-Type Diabetes; Maturity-Onset Diabetes of the Young, Type 3

  • Source: Cell reports [Cell Rep] 2022 Mar 01; Vol. 38 (9), pp. 110425.Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print Cited Medium: Internet ISSN: 2211-1247

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Academic Journal

The E3 SUMO ligase PIASγ is a novel interaction partner regulating the activity of diabetes associated hepatocyte nuclear factor-1α.

  • Authors : Kaci A; KG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, 5021, Bergen, Norway.; Department of Medical Genetics, Haukeland University Hospital, 5021, Bergen, Norway.

Subjects: Diabetes Mellitus/Diabetes Mellitus/Diabetes Mellitus/*metabolism ; Hepatocyte Nuclear Factor 1-alpha/Hepatocyte Nuclear Factor 1-alpha/Hepatocyte Nuclear Factor 1-alpha/*metabolism ; Poly-ADP-Ribose Binding Proteins/Poly-ADP-Ribose Binding Proteins/Poly-ADP-Ribose Binding Proteins/*metabolism

  • Source: Scientific reports [Sci Rep] 2018 Aug 24; Vol. 8 (1), pp. 12780. Date of Electronic Publication: 2018 Aug 24.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Diffuse glomerular nodular lesions in diabetic pigs carrying a dominant-negative mutant hepatocyte nuclear factor 1-alpha, an inheritant diabetic gene in humans.

  • Authors : Hara S; Department of Kidney and Vascular Pathology, University of Tsukuba, Tsukuba, Japan; Division of Rheumatology, Department of Internal Medicine, Kanazawa University of Graduate School of Medicine, Kanazawa, Japan.

Subjects: Genes, Dominant*; Diabetes Mellitus/Diabetes Mellitus/Diabetes Mellitus/*genetics ; Hepatocyte Nuclear Factor 1-alpha/Hepatocyte Nuclear Factor 1-alpha/Hepatocyte Nuclear Factor 1-alpha/*genetics

  • Source: PloS one [PLoS One] 2014 Mar 19; Vol. 9 (3), pp. e92219. Date of Electronic Publication: 2014 Mar 19 (Print Publication: 2014).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet

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Academic Journal

Liraglutide downregulates hepatic LDL receptor and PCSK9 expression in HepG2 cells and db/db mice through a HNF-1a dependent mechanism.

  • Authors : Yang SH; Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, BeiLiShi Road 167, Beijing, 100037, China.; Department of Cardiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China.

Subjects: Diabetes Mellitus/Diabetes Mellitus/Diabetes Mellitus/*drug therapy ; Hepatocyte Nuclear Factor 1-alpha/Hepatocyte Nuclear Factor 1-alpha/Hepatocyte Nuclear Factor 1-alpha/*metabolism ; Hepatocytes/Hepatocytes/Hepatocytes/*drug effects

  • Source: Cardiovascular diabetology [Cardiovasc Diabetol] 2018 Apr 04; Vol. 17 (1), pp. 48. Date of Electronic Publication: 2018 Apr 04.Publisher: BioMed Central Country of Publication: England NLM ID: 101147637 Publication Model: Electronic Cited Medium: Internet ISSN: 1475-2840

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Academic Journal

Pancreatic Histopathology of Human Monogenic Diabetes Due to Causal Variants in KCNJ11, HNF1A, GATA6, and LMNA.

  • Authors : Sanyoura M; Section of Adult and Pediatric Endocrinology, Diabetes, and Metabolism, The University of Chicago, Chicago, Illinois.; Jacobsen L

Subjects: Genetic Variation*; Diabetes Mellitus/Diabetes Mellitus/Diabetes Mellitus/*pathology ; GATA6 Transcription Factor/GATA6 Transcription Factor/GATA6 Transcription Factor/*genetics

  • Source: The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2018 Jan 01; Vol. 103 (1), pp. 35-45.Publisher: Oxford University Press Country of Publication: United States NLM ID: 0375362 Publication Model: Print Cited Medium: Internet ISSN:

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Report

More than kin, less than kind: one family and the many faces of diabetes in youth.

  • Authors : Franco LF; Disciplina de Endocrinologia, Universidade Federal de São Paulo (Unifesp), São Paulo, SP Brasil.; Peixoto-Barbosa R

Subjects: Genetic Predisposition to Disease*; Diabetes Mellitus/Diabetes Mellitus/Diabetes Mellitus/*genetics ; Hepatocyte Nuclear Factor 1-alpha/Hepatocyte Nuclear Factor 1-alpha/Hepatocyte Nuclear Factor 1-alpha/*genetics

  • Source: Archives of endocrinology and metabolism [Arch Endocrinol Metab] 2017 Dec; Vol. 61 (6), pp. 637-642.Publisher: Segmento Farma Editores Country of Publication: Brazil NLM ID: 101652058 Publication Model: Print Cited Medium: Internet ISSN:

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Academic Journal

Differential effects of HNF-1α mutations associated with familial young-onset diabetes on target gene regulation.

  • Authors : Galán M; Department of Biochemistry and Molecular Biology III, Faculty of Medicine, Complutense University of Madrid, Madrid, Spain.; García-Herrero CM

Subjects: Gene Expression Regulation* ; Mutation*; Diabetes Mellitus/Diabetes Mellitus/Diabetes Mellitus/*genetics

  • Source: Molecular medicine (Cambridge, Mass.) [Mol Med] 2011 Mar-Apr; Vol. 17 (3-4), pp. 256-65. Date of Electronic Publication: 2010 Dec 15.Publisher: BioMed Central Country of Publication: England NLM ID: 9501023 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Dominant-negative mutant hepatocyte nuclear factor 1alpha induces diabetes in transgenic-cloned pigs.

  • Authors : Umeyama K; BIOS Research Laboratory Inc, Hiratsuka, Kanagawa 254-0031, Japan. ; Watanabe M

Subjects: Disease Models, Animal*; Diabetes Mellitus/Diabetes Mellitus/Diabetes Mellitus/*genetics ; Hepatocyte Nuclear Factor 1-alpha/Hepatocyte Nuclear Factor 1-alpha/Hepatocyte Nuclear Factor 1-alpha/*metabolism

  • Source: Transgenic research [Transgenic Res] 2009 Oct; Vol. 18 (5), pp. 697-706. Date of Electronic Publication: 2009 Apr 09.Publisher: Kluwer Academic Publishers Country of Publication: Netherlands NLM ID: 9209120 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

The production of a diabetic mouse using constructs encoding porcine insulin promoter-driven mutant human hepatocyte nuclear factor-1alpha.

Subjects: Disease Models, Animal* ; Promoter Regions, Genetic*; Diabetes Mellitus/Diabetes Mellitus/Diabetes Mellitus/*genetics

  • Source: The Journal of reproduction and development [J Reprod Dev] 2007 Apr; Vol. 53 (2), pp. 189-200. Date of Electronic Publication: 2006 Nov 01.Publisher: Japanese Society of Animal Reproduction Country of Publication: Japan NLM ID: 9438792 Publication Model: Print-Electronic Cited Medium: Print

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  • 1-10 of  55 results for ""Hepatocyte Nuclear Factor 1-alpha""