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Academic Journal

Development of a Novel CYP3A4 Classifier Model via Site of Metabolism (SOM)-based Molecular Docking, Multivariate Analysis and Molecular Dynamics of Known Substrates and Inhibitors.

Subjects: MOLECULAR docking; CYTOCHROME P-450 CYP3A; MULTIVARIATE analysis

  • Source: Journal of Computational Biophysics & Chemistry. Mar2024, Vol. 23 Issue 2, p243-269. 27p.

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Academic Journal

Effects of clarithromycin on the pharmacokinetics of tacrolimus and expression of CYP3A4 and P‐glycoprotein in rats.

Subjects: *CYTOCHROME P-450 CYP3A; *CLARITHROMYCIN; *TACROLIMUS

  • Source: Fundamental & Clinical Pharmacology. Aug2023, Vol. 37 Issue 4, p843-848. 6p.

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Academic Journal

A Comprehensive Analysis of Human CYP3A4 Crystal Structures as a Potential Tool for Molecular Docking-Based Site of Metabolism and Enzyme Inhibition Studies.

Subjects: CYTOCHROME P-450 CYP3A; ENZYME metabolism; CRYSTAL structure

  • Source: Journal of Computational Biophysics & Chemistry. May2022, Vol. 21 Issue 3, p259-285. 27p.

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Academic Journal

The Role of CYP3A4 and CYP2C8 Polymorphism on Amiodarone Responses: Review Article.

Subjects: *CYTOCHROME P-450 CYP3A; *AMIODARONE

  • Source: Pharmacognosy Journal. May/Jun2023, Vol. 15 Issue 3, p467-470. 4p.

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Academic Journal

Effect of Strong CYP3A4 Inhibition, CYP3A4 Induction, and OATP1B1/3 Inhibition on the Pharmacokinetics of a Single Oral Dose of Sotorasib.

Subjects: *CYTOCHROME P-450 CYP3A; *MUTANT proteins; *CYTOCHROME P-450

  • Source: Clinical Pharmacology in Drug Development. Jul2024, Vol. 13 Issue 7, p810-818. 9p.

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Academic Journal

The influence of the model pesticides parathion and paraoxon on human cytochrome P450 and associated oxygenases in HepaRG cells.

Subjects: *CYTOCHROME P-450; *CYTOCHROME P-450 CYP3A; *ORGANOPHOSPHORUS pesticides

  • Source: Clinical Toxicology (15563650). May2024, Vol. 62 Issue 5, p288-295. 8p.

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Academic Journal

Synthesis and anticancer properties of a hybrid molecule with the testosterone and estradiol head-groups.

Subjects: *ANDROGEN receptors; *CYTOCHROME P-450 CYP3A; *ESTRADIOL

  • Source: Steroids. Sep2024, Vol. 209, pN.PAG-N.PAG. 1p.

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Academic Journal

Pharmacokinetic study of capivasertib and the CYP3A4 substrate midazolam in patients with advanced solid tumors.

Subjects: *CYTOCHROME P-450 CYP3A; *CLINICAL trials; *MIDAZOLAM

  • Source: Cancer Chemotherapy & Pharmacology. Aug2024, Vol. 94 Issue 2, p223-235. 13p.

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Academic Journal

3D spheroid HepaRG and fluorescent biphasic tracer for CYP3A4-mediated antibiotic interaction monitoring in sepsis.

Subjects: *CYTOCHROME P-450 CYP3A; *DRUG interactions; *SEPSIS

  • Source: Analytical & Bioanalytical Chemistry. Aug2024, Vol. 416 Issue 19, p4261-4274. 14p.

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Lack of CYP3A4 protein induction despite mRNA induction in primary hepatocytes exposed to rifabutin as a possible explanation for its low interaction risk in vivo.

Subjects: *CYTOCHROME P-450 CYP3A; *CYTOCHROME P-450; *LIVER cells

  • Source: Archives of Toxicology. Aug2024, Vol. 98 Issue 8, p2541-2556. 16p.

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  • 1-10 of  198 results for ""Cytochrome P-450 CYP3A""