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Academic Journal

STIMULATION OF THE CYCLIC AMP/GMP SIGNALLING ENHANCES THE RELAXATION OF ISOLATED HUMAN DETRUSOR SMOOTH MUSCLE ACHIEVED BY PHOSPHODIESTERASE INHIBITORS.

  • Authors : Rahardjo HE; 1University of Indonesia, School of Medicine, Cipto Mangunkusumo Hospital, Department of Urology, Jakarta, Indonesia.; Ückert S

Subjects: Cyclic GMP* ; Phosphodiesterase Inhibitors*; Cyclic AMP

  • Source: Georgian medical news [Georgian Med News] 2021 Apr (313), pp. 7-12.Publisher: Assot︠s︡iat︠s︡ii︠a︡ delovoĭ pressy Gruzii Country of Publication: Georgia (Republic) NLM ID: 101218222 Publication Model: Print

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Academic Journal

Cyclic Nucleotides Signaling and Phosphodiesterase Inhibition: Defying Alzheimer's Disease.

  • Authors : Sharma VK; Chitkara College of Pharmacy, Chitkara University, Punjab, India; Govt. College of Pharmacy, Rohru, District Shimla, Himachal Pradesh-171207, India

Subjects: Alzheimer Disease/Alzheimer Disease/Alzheimer Disease/*drug therapy ; Cyclic AMP/Cyclic AMP/Cyclic AMP/*metabolism ; Cyclic GMP/Cyclic GMP/Cyclic GMP/*metabolism

  • Source: Current drug targets [Curr Drug Targets] 2020; Vol. 21 (13), pp. 1371-1384.Publisher: Bentham Science Publishers Country of Publication: United Arab Emirates NLM ID: 100960531 Publication Model: Print Cited Medium: Internet

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Academic Journal

Phosphodiesterase-2 inhibitor reverses post-traumatic stress induced fear memory deficits and behavioral changes via cAMP/cGMP pathway.

  • Authors : Chen L; Department of Clinical Pharmacology, Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310006, PR China; Brain Institute, School of Pharmacy, Wenzhou Medical University, Wenzhou, Zhejiang Province, China.

Subjects: Fear*; Behavior, Animal/Behavior, Animal/Behavior, Animal/*drug effects ; Brain/Brain/Brain/*drug effects

  • Source: European journal of pharmacology [Eur J Pharmacol] 2021 Jan 15; Vol. 891, pp. 173768. Date of Electronic Publication: 2020 Dec 01.Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Identification of lead BAY60-7550 analogues as potential inhibitors that utilize the hydrophobic groove in PDE2A: a molecular dynamics simulation study.

  • Authors : Kumar J; Department of Chemistry, Jamia Millia Islamia, Central University, New Delhi, India, 110025.; Umar T

Subjects: Cyclic AMP/Cyclic AMP/Cyclic AMP/*chemistry ; Cyclic GMP/Cyclic GMP/Cyclic GMP/*chemistry ; Cyclic Nucleotide Phosphodiesterases, Type 2/Cyclic Nucleotide Phosphodiesterases, Type 2/Cyclic Nucleotide Phosphodiesterases, Type 2/*antagonists & inhibitors

  • Source: Journal of molecular modeling [J Mol Model] 2017 Jan; Vol. 23 (1), pp. 7. Date of Electronic Publication: 2016 Dec 13.Publisher: Springer Country of Publication: Germany NLM ID: 9806569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 0948-5023

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Academic Journal

The Novel Phosphodiesterase 9A Inhibitor BI 409306 Increases Cyclic Guanosine Monophosphate Levels in the Brain, Promotes Synaptic Plasticity, and Enhances Memory Function in Rodents.

  • Authors : Rosenbrock H; Boehringer Ingelheim International GmbH, Biberach an der Riss, Germany (H.R., R.G., G.S., E.K., F.R., H.F., A.M., C.D.-C.); Leibniz Institute for Neurobiology, Magdeburg, Germany (K.G.R., U.H.S.)

Subjects: Brain Chemistry/Brain Chemistry/Brain Chemistry/*drug effects ; Cyclic GMP/Cyclic GMP/Cyclic GMP/*analysis ; Memory/Memory/Memory/*drug effects

  • Source: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2019 Dec; Vol. 371 (3), pp. 633-641. Date of Electronic Publication: 2019 Oct 02.Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 0376362 Publication Model:

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Academic Journal

Clinical relevance of cyclic GMP modulators: A translational success story of network pharmacology.

  • Authors : Oettrich JM; Department of Pharmacology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands.; Dao VT

Subjects: Cyclic GMP/Cyclic GMP/Cyclic GMP/*metabolism ; Drug Discovery/Drug Discovery/Drug Discovery/*methods ; Enzyme Activators/Enzyme Activators/Enzyme Activators/*pharmacology

  • Source: Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2016 Apr; Vol. 99 (4), pp. 360-2. Date of Electronic Publication: 2016 Feb 13.Publisher: Wiley Country of Publication: United States NLM ID: 0372741 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-6535

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Academic Journal

A novel PDE9 inhibitor WYQ-C36D ameliorates corticosterone-induced neurotoxicity and depression-like behaviors by cGMP-CREB-related signaling.

  • Authors : Huang XF; School of Pharmaceutical Engineering and Life Sciences, Changzhou University, Changzhou, Jiangsu, China.; Jiang WT

Subjects: Corticosterone/Corticosterone/Corticosterone/*toxicity ; Cyclic GMP/Cyclic GMP/Cyclic GMP/*metabolism ; Depression/Depression/Depression/*drug therapy

  • Source: CNS neuroscience & therapeutics [CNS Neurosci Ther] 2018 Oct; Vol. 24 (10), pp. 889-896. Date of Electronic Publication: 2018 May 02.Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101473265 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Phosphodiesterase 2 inhibition preferentially promotes NO/guanylyl cyclase/cGMP signaling to reverse the development of heart failure.

  • Authors : Baliga RS; William Harvey Research Institute, Barts & The London School of Medicine & Dentistry, Queen Mary University of London, EC1M 6BQ London, United Kingdom.; Preedy MEJ

Subjects: Cyclic GMP/Cyclic GMP/Cyclic GMP/*physiology ; Cyclic Nucleotide Phosphodiesterases, Type 2/Cyclic Nucleotide Phosphodiesterases, Type 2/Cyclic Nucleotide Phosphodiesterases, Type 2/*physiology ; Guanylate Cyclase/Guanylate Cyclase/Guanylate Cyclase/*physiology

  • Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2018 Jul 31; Vol. 115 (31), pp. E7428-E7437. Date of Electronic Publication: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Preventive effect of zaprinast and 3-isobutyl, 1-methylxanthine (phosphodiesterase inhibitors) on gastric injury induced by nonsteroidal antiinflammatory drugs in rats.

  • Authors : Herrerías JM; Servicio de Aparato Digestivo, Hospital Universitario Virgen de la Macarena, 41009 Seville, Spain.; Esteban JM

Subjects: 1-Methyl-3-isobutylxanthine/1-Methyl-3-isobutylxanthine/1-Methyl-3-isobutylxanthine/*pharmacology ; Anti-Inflammatory Agents, Non-Steroidal/Anti-Inflammatory Agents, Non-Steroidal/Anti-Inflammatory Agents, Non-Steroidal/*pharmacology ; Cyclic GMP/Cyclic GMP/Cyclic GMP/*analysis

  • Source: Digestive diseases and sciences [Dig Dis Sci] 2003 May; Vol. 48 (5), pp. 986-91.Publisher: Springer Science + Business Media Country of Publication: United States NLM ID: 7902782 Publication Model: Print Cited Medium: Print ISSN:

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Academic Journal

Inhibition of phosphodiesterase 2 augments cGMP and cAMP signaling to ameliorate pulmonary hypertension.

  • Authors : Bubb KJ; From the William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London (K.J.B., S.L.T., R.S.B., A.J.H.); and Centre for Clinical Pharmacology, University College London (J.P., L.H.C., R.J.M.), London, United Kingdom.

Subjects: Cyclic AMP/Cyclic AMP/Cyclic AMP/*physiology ; Cyclic GMP/Cyclic GMP/Cyclic GMP/*physiology ; Cyclic Nucleotide Phosphodiesterases, Type 2/Cyclic Nucleotide Phosphodiesterases, Type 2/Cyclic Nucleotide Phosphodiesterases, Type 2/*antagonists & inhibitors

  • Source: Circulation [Circulation] 2014 Aug 05; Vol. 130 (6), pp. 496-507. Date of Electronic Publication: 2014 Jun 04.Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0147763 Publication Model: Print-Electronic Cited Medium:

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  • 1-10 of  599 results for ""PHOSPHODIESTERASE inhibitors""