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Academic Journal

Translational Models and Tools to Reduce Clinical Trials and Improve Regulatory Decision Making for QTc and Proarrhythmia Risk (ICH E14/S7B Updates).

Subjects: PROARRHYTHMIA; DECISION making; CLINICAL trials

  • Source: Clinical Pharmacology & Therapeutics; Feb2021, Vol. 109 Issue 2, p319-333, 15p

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Automated Algorithm for J-Tpeak and Tpeak-Tend Assessment of Drug-Induced Proarrhythmia Risk.

Subjects: *PROARRHYTHMIA; *HEART beat; *ELECTROCARDIOGRAPHY

  • Source: PLoS ONE. 12/30/2016, Vol. 11 Issue 12, p1-18. 18p.

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The prospective IQ-CSRC trial: A prototype early clinical proarrhythmia assessment investigation for replacing the ICH E14 thorough QTc (TQT) study.

Subjects: *PROARRHYTHMIA; *HEART rate monitoring; *CLINICAL trials

  • Source: Journal of Pharmacological & Toxicological Methods. Jul2016, Vol. 80, p1-8. 8p.

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Evaluating cardiac risk: exposure response analysis in early clinical drug development.

Subjects: DRUG development; CLINICAL trials; PROARRHYTHMIA

  • Source: Drug, Healthcare & Patient Safety; Apr2018, Vol. 10, p27-36, 10p

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Academic Journal

Mechanistic Model-Informed Proarrhythmic Risk Assessment of Drugs: Review of the 'CiPA' Initiative and Design of a Prospective Clinical Validation Study.

Subjects: PROARRHYTHMIA; HEART cells; ELECTROCARDIOGRAPHY

  • Source: Clinical Pharmacology & Therapeutics; Jan2018, Vol. 103 Issue 1, p54-66, 13p

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Academic Journal

In vitro to clinical translation to improve proarrhythmic risk assessment.

Subjects: *PROARRHYTHMIA; *POTASSIUM channels; *CLINICAL trials

  • Source: Journal of Pharmacological & Toxicological Methods. Sep2016, Vol. 81, p360-360. 1p.

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Academic Journal

An evaluation of hERG current assay performance: Translating preclinical safety studies to clinical QT prolongation

Subjects: *PROARRHYTHMIA; *QUANTITATIVE research; *CLINICAL trials

  • Source: Pharmacology & Therapeutics. Feb2011, Vol. 129 Issue 2, p109-119. 11p.

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Academic Journal

Drug-drug interactions and QT prolongation as a commonly assessed cardiac effect - comprehensive overview of clinical trials.

Subjects: DRUG interactions; PROARRHYTHMIA; MUSCLE cells

  • Source: BMC Pharmacology & Toxicology; 3/10/2016, Vol. 17, p1-15, 15p

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Academic Journal

Proarrhythmia with Class III Antiarrhythmic Drugs: Definition, Electrophysiologic Mechanisms, Incidence, Predisposing Factors, and Clinical Implications.

Subjects: ARRHYTHMIA treatment; HEART diseases; THERAPEUTICS

  • Source: Journal of Cardiovascular Electrophysiology; Oct1995, Vol. 6 Issue 10P2, p920-936, 17p

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Academic Journal

Electrocardiographic Biomarkers for Detection of Drug-Induced Late Sodium Current Block.

Subjects: DRUG side effects; ELECTROCARDIOGRAPHY; BIOMARKERS

  • Source: PLoS ONE; 12/30/2016, Vol. 11 Issue 12, p1-16, 16p

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  • 1-10 of  215 results for ""PROARRHYTHMIA""