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Academic Journal

Disentangling the formation, mechanism, and evolvement of the covalent methanesulfonyl fluoride acetylcholinesterase adduct: Insights into an aged-like inactive complex susceptible to reactivation by a combination of nucleophiles.

  • Authors : Stojan J; Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.; Pesaresi A

Subjects: Cholinesterase Inhibitors*/Cholinesterase Inhibitors*/Cholinesterase Inhibitors*/chemistry ; Cholinesterase Inhibitors*/Cholinesterase Inhibitors*/Cholinesterase Inhibitors*/metabolism ; Cholinesterase Inhibitors*/Cholinesterase Inhibitors*/Cholinesterase Inhibitors*/pharmacology

  • Source: Protein science : a publication of the Protein Society [Protein Sci] 2024 May; Vol. 33 (5), pp. e4977.Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 9211750 Publication Model: Print Cited Medium: Internet

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Academic Journal

A Pralidoxime Nanocomplex Formulation Targeting Transferrin Receptors for Reactivation of Brain Acetylcholinesterase After Exposure of Mice to an Anticholinesterase Organophosphate.

  • Authors : Pirollo KF; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, 20057, USA.; Moghe M

Subjects: Cholinesterase Inhibitors*/Cholinesterase Inhibitors*/Cholinesterase Inhibitors*/toxicity ; Cholinesterase Reactivators*/Cholinesterase Reactivators*/Cholinesterase Reactivators*/pharmacology ; Cholinesterase Reactivators*/Cholinesterase Reactivators*/Cholinesterase Reactivators*/chemistry

  • Source: International journal of nanomedicine [Int J Nanomedicine] 2024 Jan 12; Vol. 19, pp. 307-326. Date of Electronic Publication: 2024 Jan 12 (Print Publication: 2024).Publisher: DOVE Medical Press Country of Publication: New Zealand NLM ID: 101263847 Publication Model: eCollection Cited Medium: Internet ISSN:

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Academic Journal

Surface modification of pralidoxime chloride-loaded solid lipid nanoparticles for enhanced brain reactivation of organophosphorus-inhibited AChE: Pharmacokinetics in rat.

  • Authors : Buzyurova DN; Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, Arbuzov St., 8, Kazan, 420088, Russia.; Pashirova TN

Subjects: Antidotes/Antidotes/Antidotes/*administration & dosage ; Cholinesterase Inhibitors/Cholinesterase Inhibitors/Cholinesterase Inhibitors/*toxicity ; Cholinesterase Reactivators/Cholinesterase Reactivators/Cholinesterase Reactivators/*administration & dosage

  • Source: Toxicology [Toxicology] 2020 Nov; Vol. 444, pp. 152578. Date of Electronic Publication: 2020 Sep 06.Publisher: Elsevier Country of Publication: Ireland NLM ID: 0361055 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3185

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Academic Journal

Efficacy Assessment of an Uncharged Reactivator of NOP-Inhibited Acetylcholinesterase Based on Tetrahydroacridine Pyridine-Aldoxime Hybrid in Mouse Compared to Pralidoxime.

  • Authors : Calas AG; Département de Toxicologie et Risques Chimiques, Institut de Recherche Biomédicale des Armées, F-91220 Brétigny-sur-Orge, France.; COGNition and ACtion Group, UMR 8257, CNRS-MD-UPV, Centre Universitaire des Saints-Pères, F-75006 Paris, France.

Subjects: Acetylcholinesterase/Acetylcholinesterase/Acetylcholinesterase/*metabolism ; Cholinesterase Inhibitors/Cholinesterase Inhibitors/Cholinesterase Inhibitors/*pharmacology ; Pralidoxime Compounds/Pralidoxime Compounds/Pralidoxime Compounds/*pharmacology

  • Source: Biomolecules [Biomolecules] 2020 Jun 04; Vol. 10 (6). Date of Electronic Publication: 2020 Jun 04.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101596414 Publication Model: Electronic Cited Medium: Internet ISSN: 2218-273X

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Academic Journal

Molecular modeling studies on the interactions of 7-methoxytacrine-4-pyridinealdoxime, 4-PA, 2-PAM, and obidoxime with VX-inhibited human acetylcholinesterase: a near attack conformation approach.

  • Authors : da Silva JAV; a Laboratory of Molecular Modeling Applied to the Chemical and Biological Defense (LMCBD), Department of Chemical Engineering , Military Institute of Engineering , Rio de Janeiro/RJ , Brazil.; Nepovimova E

Subjects: Cholinesterase Inhibitors/Cholinesterase Inhibitors/Cholinesterase Inhibitors/*pharmacology ; Obidoxime Chloride/Obidoxime Chloride/Obidoxime Chloride/*pharmacology ; Organothiophosphorus Compounds/Organothiophosphorus Compounds/Organothiophosphorus Compounds/*pharmacology

  • Source: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2019 Dec; Vol. 34 (1), pp. 1018-1029.Publisher: Taylor & Francis Country of Publication: England NLM ID: 101150203 Publication Model: Print Cited Medium: Internet ISSN: 1475-6374

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Academic Journal

In silico and in vitro evaluation of two novel oximes (K378 and K727) in comparison to K-27 and pralidoxime against paraoxon-ethyl intoxication.

  • Authors : Arshad M; a Department of Biosciences , COMSATS Institute of Information Technology , Islamabad , Pakistan.; Fatmi MQ

Subjects: Molecular Docking Simulation*; Antidotes/Antidotes/Antidotes/*pharmacology ; Cholinesterase Inhibitors/Cholinesterase Inhibitors/Cholinesterase Inhibitors/*toxicity

  • Source: Toxicology mechanisms and methods [Toxicol Mech Methods] 2018 Jan; Vol. 28 (1), pp. 62-68. Date of Electronic Publication: 2017 Aug 04.Publisher: Informa Healthcare Country of Publication: England NLM ID: 101134521 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Superior efficacy of HI-6 dimethanesulfonate over pralidoxime methylsulfate against Russian VX poisoning in cynomolgus monkeys (Macaca fascicularis).

  • Authors : Reymond C; Institut de Recherche Biomédicale des Armées (IRBA), département de Toxicologie et Risques Chimiques, F-91 220 Brétigny-sur-Orge, France.; Jaffré N

Subjects: Cholinesterase Inhibitors/Cholinesterase Inhibitors/Cholinesterase Inhibitors/*poisoning ; Cholinesterase Reactivators/Cholinesterase Reactivators/Cholinesterase Reactivators/*therapeutic use ; Nerve Agents/Nerve Agents/Nerve Agents/*poisoning

  • Source: Toxicology [Toxicology] 2018 Dec 01; Vol. 410, pp. 96-105. Date of Electronic Publication: 2018 Sep 12.Publisher: Elsevier Country of Publication: Ireland NLM ID: 0361055 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3185

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Academic Journal

Novel pyridinium oximes enhance 24-h survivability against a lethal dose of nerve agent surrogate in adult female rats.

  • Authors : Garcia JM; Center for Environmental Health Sciences, Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, P.O. Box 6100, Mississippi State, MS, 39762, USA. Electronic address: .; Meek EC

Subjects: Antidotes/Antidotes/Antidotes/*pharmacology ; Cholinesterase Inhibitors/Cholinesterase Inhibitors/Cholinesterase Inhibitors/*toxicity ; Nerve Agents/Nerve Agents/Nerve Agents/*toxicity

  • Source: Toxicology [Toxicology] 2020 Dec 15; Vol. 446, pp. 152626. Date of Electronic Publication: 2020 Nov 04.Publisher: Elsevier Country of Publication: Ireland NLM ID: 0361055 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3185

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Academic Journal

The First Use of Pralidoxime in a Child With Rivastigmine Poisoning.

Subjects: Cholinesterase Inhibitors/Cholinesterase Inhibitors/Cholinesterase Inhibitors/*poisoning ; Cholinesterase Reactivators/Cholinesterase Reactivators/Cholinesterase Reactivators/*therapeutic use ; Pralidoxime Compounds/Pralidoxime Compounds/Pralidoxime Compounds/*therapeutic use

  • Source: Pediatric emergency care [Pediatr Emerg Care] 2018 Oct; Vol. 34 (10), pp. e184-e186.Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 8507560 Publication Model: Print Cited Medium: Internet ISSN:

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Academic Journal

The role of the oximes HI-6 and HS-6 inside human acetylcholinesterase inhibited with nerve agents: a computational study.

  • Authors : Cuya T; a Faculty of Technology , University of the State of Rio de Janeiro , Resende, Rio de Janeiro , Brazil.; Gonçalves ADS

Subjects: Acetylcholinesterase/Acetylcholinesterase/Acetylcholinesterase/*metabolism ; Chemical Warfare Agents/Chemical Warfare Agents/Chemical Warfare Agents/*chemistry ; Cholinesterase Inhibitors/Cholinesterase Inhibitors/Cholinesterase Inhibitors/*chemistry

  • Source: Journal of biomolecular structure & dynamics [J Biomol Struct Dyn] 2018 Oct; Vol. 36 (13), pp. 3444-3452. Date of Electronic Publication: 2017 Oct 27.Publisher: Taylor & Francis Country of Publication: England NLM ID: 8404176 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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  • 1-10 of  289 results for ""Pralidoxime Compounds""