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Academic Journal

The Proprotein Convertases in Hypercholesterolemia and Cardiovascular Diseases: Emphasis on Proprotein Convertase Subtilisin/Kexin 9.

  • Authors : Seidah NG; Laboratory of Biochemical Neuroendocrinology, Institut de Recherches Cliniques de Montréal, affiliated to Université de Montréal, QC, Canada (N.G.S., A.P.); LVTS, INSERM U1148, Hôpital Xavier-Bichat, Paris, France (M.A., C.B.)

Subjects: Cholesterol/Cholesterol/Cholesterol/*blood ; Hypercholesterolemia/Hypercholesterolemia/Hypercholesterolemia/*enzymology ; Proprotein Convertase 9/Proprotein Convertase 9/Proprotein Convertase 9/*metabolism

  • Source: Pharmacological reviews [Pharmacol Rev] 2017 Jan; Vol. 69 (1), pp. 33-52.Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 0421737 Publication Model: Print

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Academic Journal

PCSK9 inhibition in patients with hypercholesterolemia.

  • Authors : Desai NR; Section of Cardiovascular Medicine, Center for Outcomes Research and Evaluation, Yale-New Haven Hospital, Yale School of Medicine, New Haven, CT.; Sabatine MS

Subjects: Antibodies, Monoclonal/Antibodies, Monoclonal/Antibodies, Monoclonal/*therapeutic use ; Anticholesteremic Agents/Anticholesteremic Agents/Anticholesteremic Agents/*therapeutic use ; Cholesterol/Cholesterol/Cholesterol/*blood

  • Source: Trends in cardiovascular medicine [Trends Cardiovasc Med] 2015 Oct; Vol. 25 (7), pp. 567-74. Date of Electronic Publication: 2015 Feb 11.Publisher: Elsevier Science Publishing Country of Publication: United States NLM ID: 9108337 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

PCSK9 and its modulation.

  • Authors : Cui CJ; Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beilishi Road 167, Beijing 100037, PR China.; Li S

Subjects: Cholesterol/Cholesterol/Cholesterol/*metabolism ; Molecular Targeted Therapy/Molecular Targeted Therapy/Molecular Targeted Therapy/*methods ; Proprotein Convertases/Proprotein Convertases/Proprotein Convertases/*genetics

  • Source: Clinica chimica acta; international journal of clinical chemistry [Clin Chim Acta] 2015 Feb 02; Vol. 440, pp. 79-86. Date of Electronic Publication: 2014 Nov 06.Publisher: Elsevier Country of Publication: Netherlands NLM ID: 1302422 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

The Liver Clock Controls Cholesterol Homeostasis through Trib1 Protein-mediated Regulation of PCSK9/Low Density Lipoprotein Receptor (LDLR) Axis.

  • Authors : Ma D; From the Life Sciences Institute and Department of Cell and Developmental Biology and.; Liu T

Subjects: Cholesterol/Cholesterol/Cholesterol/*metabolism ; Circadian Clocks/Circadian Clocks/Circadian Clocks/*physiology ; Intracellular Signaling Peptides and Proteins/Intracellular Signaling Peptides and Proteins/Intracellular Signaling Peptides and Proteins/*metabolism

  • Source: The Journal of biological chemistry [J Biol Chem] 2015 Dec 25; Vol. 290 (52), pp. 31003-12. Date of Electronic Publication: 2015 Nov 07.Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication

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Academic Journal

A cholesterol-lowering VLP vaccine that targets PCSK9.

  • Authors : Crossey E; Department of Molecular Genetics and Microbiology, University of New Mexico, MSC08-4660, Albuquerque, NM 87131, USA.; Amar MJA

Subjects: Cholesterol/Cholesterol/Cholesterol/*blood ; Proprotein Convertases/Proprotein Convertases/Proprotein Convertases/*antagonists & inhibitors ; Vaccines, Virus-Like Particle/Vaccines, Virus-Like Particle/Vaccines, Virus-Like Particle/*administration & dosage

  • Source: Vaccine [Vaccine] 2015 Oct 26; Vol. 33 (43), pp. 5747-5755. Date of Electronic Publication: 2015 Sep 26.Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 8406899 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

The cholesterol, fatty acid and triglyceride synthesis pathways regulated by site 1 protease (S1P) are required for efficient replication of severe fever with thrombocytopenia syndrome virus.

  • Authors : Urata S; Department of Emerging Infectious Diseases, Institute of Tropical Medicine (NEKKEN), Japan; National Research Center for the Control and Prevention of Infectious Diseases (CCPID), Nagasaki University, 1-12-4 Sakamoto, Nagasaki, 852-8523, Japan. Electronic address: .

Subjects: Virus Replication*; Cholesterol/Cholesterol/Cholesterol/*metabolism ; Fatty Acids/Fatty Acids/Fatty Acids/*metabolism

  • Source: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2018 Sep 05; Vol. 503 (2), pp. 631-636. Date of Electronic Publication: 2018 Jun 14.Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

PCSK9 inhibition fails to alter hepatic LDLR, circulating cholesterol, and atherosclerosis in the absence of ApoE.

Subjects: Apolipoproteins E/Apolipoproteins E/Apolipoproteins E/*deficiency ; Atherosclerosis/Atherosclerosis/Atherosclerosis/*metabolism ; Cholesterol/Cholesterol/Cholesterol/*blood

  • Source: Journal of lipid research [J Lipid Res] 2014 Nov; Vol. 55 (11), pp. 2370-9. Date of Electronic Publication: 2014 Sep 25.Publisher: Elsevier Country of Publication: United States NLM ID: 0376606 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Cartilage-specific ablation of site-1 protease in mice results in the endoplasmic reticulum entrapment of type IIb procollagen and down-regulation of cholesterol and lipid homeostasis.

  • Authors : Patra D; Department of Orthopaedic Surgery, Washington University School of Medicine, St. Louis, Missouri, United States of America.; DeLassus E

Subjects: Cartilage/Cartilage/Cartilage/*metabolism ; Cholesterol/Cholesterol/Cholesterol/*metabolism ; Collagen Type II/Collagen Type II/Collagen Type II/*metabolism

  • Source: PloS one [PLoS One] 2014 Aug 22; Vol. 9 (8), pp. e105674. Date of Electronic Publication: 2014 Aug 22 (Print Publication: 2014).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet

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Academic Journal

Anti-PCSK9 antibody effectively lowers cholesterol in patients with statin intolerance: the GAUSS-2 randomized, placebo-controlled phase 3 clinical trial of evolocumab.

Subjects: Antibodies, Monoclonal/Antibodies, Monoclonal/Antibodies, Monoclonal/*drug effects ; Cholesterol/Cholesterol/Cholesterol/*blood ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/Hydroxymethylglutaryl-CoA Reductase Inhibitors/Hydroxymethylglutaryl-CoA Reductase Inhibitors/*administration & dosage

  • Source: Journal of the American College of Cardiology [J Am Coll Cardiol] 2014 Jun 17; Vol. 63 (23), pp. 2541-2548. Date of Electronic Publication: 2014 Mar 30.Publisher: Elsevier Biomedical Country of Publication: United States NLM ID: 8301365 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Transintestinal cholesterol excretion is an active metabolic process modulated by PCSK9 and statin involving ABCB1.

  • Authors : Le May C; INSERM, UMR 1087, CNRS UMR 6291, Nantes F-44000, France.; Berger JM

Subjects: ATP Binding Cassette Transporter, Subfamily B/ATP Binding Cassette Transporter, Subfamily B/ATP Binding Cassette Transporter, Subfamily B/*metabolism ; ATP Binding Cassette Transporter, Subfamily B, Member 1/ATP Binding Cassette Transporter, Subfamily B, Member 1/ATP Binding Cassette Transporter, Subfamily B, Member 1/*metabolism ; Cholesterol/Cholesterol/Cholesterol/*metabolism

  • Source: Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2013 Jul; Vol. 33 (7), pp. 1484-93. Date of Electronic Publication: 2013 Apr 04.Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 9505803 Publication Model: Print-Electronic Cited Medium:

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  • 1-10 of  437 results for ""PROPROTEIN convertases""