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Plant polysaccharides attenuate fluorouracil toxicity for the small intestinal epithelium

• Authors : Safonova, E.A.; Lopatina, K.A.; Vychuzhanina, A.V.

• Source: Bulletin of Experimental Biology and Medicine. June, 2016, Vol. 161 Issue 2, p308, 4 p.

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Agricola

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MIR27A Gene Polymorphism Modifies the Effect of Common DPYD Gene Variants on Severe Toxicity in Patients with Gastrointestinal Tumors Treated with Fluoropyrimidine-Based Anticancer Therapy.

• Authors : Ikonnikova, Anna; Fedorinov, Denis; Gryadunov, Dmitry

Subjects: DIHYDROPYRIMIDINE dehydrogenase; GENETIC variation; GENETIC polymorphisms

• Source: International Journal of Molecular Sciences; Aug2024, Vol. 25 Issue 15, p8503, 13p

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Neoadjuvant short-course radiotherapy or chemoradiation plus consolidative chemotherapy followed by radical operation for locally advanced rectal cancer.

• Authors : Shing Fung Lee; Pui Lam Yip; Barry Wo

Subjects: RECTAL cancer; ABDOMINOPERINEAL resection; CHEMORADIOTHERAPY

• Source: Frontiers in Oncology; 2024, p1-11, 11p

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5-Fluorouracil Toxicity and Dihydropyrimidine Dehydrogenase Enzyme: Implications for Practice.

• Authors : Latchman, Jessica; Guastella, Ann; Tofthagen, Cindy

Subjects: STOMATITIS treatment; TREATMENT of drug toxicity; DRUG eruptions

• Source: Clinical Journal of Oncology Nursing. Oct2014, Vol. 18 Issue 5, p581-585. 5p. 1 Color Photograph, 2 Charts.

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Fluorouracil-induced leukoencephalopathy mimicking neuroleptic malignant syndrome: a case report.

• Authors : Hemachudha, Pasin; Rattanawong, Wanakorn; Pongpitakmetha, Thanakit

Subjects: LEUKOENCEPHALOPATHIES; NEUROLEPTIC malignant syndrome; SYMPTOMS

• Source: Journal of Medical Case Reports; 3/8/2023, Vol. 17 Issue 1, p1-5, 5p

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Case report: Uridine triacetate in the management of delayed onset 5-fluorouracil toxicity: A case report and review of literature.

• Authors : Jacob, Aasems; Veedu, Janeesh Sekkath; Selene, Insija

Subjects: URIDINE; ANTIMETABOLITES; ANTINEOPLASTIC agents

• Source: Frontiers in Pharmacology; 9/7/2022, Vol. 12, p01-05, 5p

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Predicting 5-fluorouracil toxicity: DPD genotype and 5,6-dihydrouracil:uracil ratio.

• Authors : Sistonen, Johanna; Büchel, Barbara; Froehlich, Tanja K

• Source: Pharmacogenomics; Oct2014, Vol. 15 Issue 13, p1653-1666, 14p

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Frequency of dihydropyrimidine dehydrogenase and UDP-glucuronosyltransferase 1A1 variants in cancer patients requiring chemotherapy: A single-center study in southern India.

• Authors : Gangavarapu, Kevin; Bora, Nandini Shyamali; Srinivas, Maddali

Subjects: DIHYDROPYRIMIDINE dehydrogenase; DRUG side effects; GLUCURONOSYLTRANSFERASEINDIA

• Source: Journal of Clinical & Basic Research; 2023, Vol. 7 Issue 1, p6-8, 3p

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Haplotype structure defines effects of common DPYD variants c.85T > C (rs1801265) and c.496A > G (rs2297595) on dihydropyrimidine dehydrogenase activity: Implication for 5‐fluorouracil toxicity.

• Authors : Hamzic, Seid; Schärer, Dominic; Offer, Steven M.

Subjects: DIHYDROPYRIMIDINE dehydrogenase; FLUOROURACIL; LINKAGE disequilibrium

• Source: British Journal of Clinical Pharmacology; Aug2021, Vol. 87 Issue 8, p3234-3243, 10p

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