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Academic Journal

Utility of human cytochrome P450 inhibition data in the assessment of drug-induced liver injury.

  • Authors : Kaito S; School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan.; Takeshita JI

Subjects: Chemical and Drug Induced Liver Injury* ; Cytochrome P-450 Enzyme Inhibitors*/Cytochrome P-450 Enzyme Inhibitors*/Cytochrome P-450 Enzyme Inhibitors*/pharmacology ; Cytochrome P-450 Enzyme System*/Cytochrome P-450 Enzyme System*/Cytochrome P-450 Enzyme System*/metabolism

  • Source: Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2024 Jul; Vol. 54 (7), pp. 411-419. Date of Electronic Publication: 2024 Aug 21.Publisher: Informa Healthcare Country of Publication: England NLM ID: 1306665 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

A hepatoprotection study of Radix Bupleuri on acetaminophen-induced liver injury based on CYP450 inhibition.

  • Authors : Wang YX; Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, China; Jiangsu Institute for Food and Drug Control, Nanjing 210019, China.

Subjects: Acetaminophen/Acetaminophen/Acetaminophen/*analogs & derivatives ; Bupleurum/Bupleurum/Bupleurum/*chemistry ; Chemical and Drug Induced Liver Injury/Chemical and Drug Induced Liver Injury/Chemical and Drug Induced Liver Injury/*prevention & control

  • Source: Chinese journal of natural medicines [Chin J Nat Med] 2019 Jul; Vol. 17 (7), pp. 517-524.Publisher: Science Press Country of Publication: China NLM ID: 101504416 Publication Model: Print Cited Medium: Internet ISSN: 1875-5364

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Academic Journal

Piperine Enhances the Antioxidant and Anti-Inflammatory Activities of Thymoquinone against Microcystin-LR-Induced Hepatotoxicity and Neurotoxicity in Mice.

  • Authors : Abdel-Daim MM; Pharmacology Department, Faculty of Veterinary Medicine, Suez Canal University, Ismailia 41522, Egypt.; Sayed AA

Subjects: Alkaloids/Alkaloids/Alkaloids/*therapeutic use ; Anti-Inflammatory Agents/Anti-Inflammatory Agents/Anti-Inflammatory Agents/*therapeutic use ; Benzodioxoles/Benzodioxoles/Benzodioxoles/*therapeutic use

  • Source: Oxidative medicine and cellular longevity [Oxid Med Cell Longev] 2019 Apr 16; Vol. 2019, pp. 1309175. Date of Electronic Publication: 2019 Apr 16 (Print Publication: 2019).Publisher: Hindawi Pub. Corp Country of Publication: United States NLM ID: 101479826 Publication Model: eCollection Cited Medium: Internet ISSN:

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Academic Journal

Association of CYP1A1 and CYP1B1 inhibition in in vitro assays with drug-induced liver injury.

  • Authors : Shimizu Y; Laboratory of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka.; Sasaki T

Subjects: Chemical and Drug Induced Liver Injury/Chemical and Drug Induced Liver Injury/Chemical and Drug Induced Liver Injury/*etiology ; Cytochrome P-450 CYP1A1/Cytochrome P-450 CYP1A1/Cytochrome P-450 CYP1A1/*antagonists & inhibitors ; Cytochrome P-450 CYP1B1/Cytochrome P-450 CYP1B1/Cytochrome P-450 CYP1B1/*antagonists & inhibitors

  • Source: The Journal of toxicological sciences [J Toxicol Sci] 2021; Vol. 46 (4), pp. 167-176.Publisher: Doku Sayō Kenkyūkai Country of Publication: Japan NLM ID: 7805798 Publication Model: Print Cited Medium: Internet ISSN: 1880-3989

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Academic Journal

Curcumin Prevents Aflatoxin B₁ Hepatoxicity by Inhibition of Cytochrome P450 Isozymes in Chick Liver.

  • Authors : Zhang NY; Department of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, China. .; Qi M

Subjects: Aflatoxin B1/Aflatoxin B1/Aflatoxin B1/*toxicity ; Chemical and Drug Induced Liver Injury/Chemical and Drug Induced Liver Injury/Chemical and Drug Induced Liver Injury/*metabolism ; Curcumin/Curcumin/Curcumin/*pharmacology

  • Source: Toxins [Toxins (Basel)] 2016 Nov 10; Vol. 8 (11). Date of Electronic Publication: 2016 Nov 10.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101530765 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6651

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Academic Journal

Mechanism-based inhibition of CYPs and RMs-induced hepatoxicity by rutaecarpine.

  • Authors : Zhang FL; a School of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Nankai District , Tianjin , P.R. China and.; He X

Subjects: Cytochrome P-450 Enzyme Inhibitors*/Cytochrome P-450 Enzyme Inhibitors*/Cytochrome P-450 Enzyme Inhibitors*/adverse effects ; Cytochrome P-450 Enzyme Inhibitors*/Cytochrome P-450 Enzyme Inhibitors*/Cytochrome P-450 Enzyme Inhibitors*/pharmacokinetics ; Cytochrome P-450 Enzyme Inhibitors*/Cytochrome P-450 Enzyme Inhibitors*/Cytochrome P-450 Enzyme Inhibitors*/pharmacology

  • Source: Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2015; Vol. 45 (11), pp. 978-89. Date of Electronic Publication: 2015 Jun 08.Publisher: Informa Healthcare Country of Publication: England NLM ID: 1306665 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

The gap junction inhibitor 2-aminoethoxy-diphenyl-borate protects against acetaminophen hepatotoxicity by inhibiting cytochrome P450 enzymes and c-jun N-terminal kinase activation.

  • Authors : Du K; Department of Pharmacology, Toxicology & Therapeutics, University of Kansas Medical Center, Kansas City, KS, USA.; Williams CD

Subjects: Cytochrome P-450 Enzyme Inhibitors*; Acetaminophen/Acetaminophen/Acetaminophen/*adverse effects ; Boron Compounds/Boron Compounds/Boron Compounds/*pharmacology

  • Source: Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2013 Dec 15; Vol. 273 (3), pp. 484-91. Date of Electronic Publication: 2013 Sep 23.Publisher: Academic Press Country of Publication: United States NLM ID: 0416575 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Mechanism-based inhibition of CYP450: an indicator of drug-induced hepatotoxicity.

  • Authors : Feng S; School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Nankai District, Tianjin, P.R. China, 300193. .; He X

Subjects: Cytochrome P-450 Enzyme Inhibitors*; Chemical and Drug Induced Liver Injury/Chemical and Drug Induced Liver Injury/Chemical and Drug Induced Liver Injury/*metabolism; Animals

  • Source: Current drug metabolism [Curr Drug Metab] 2013 Nov; Vol. 14 (9), pp. 921-45.Publisher: Bentham Science Publishers Country of Publication: Netherlands NLM ID: 100960533 Publication Model: Print Cited Medium: Internet ISSN:

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Academic Journal

Purinergic receptor antagonist A438079 protects against acetaminophen-induced liver injury by inhibiting p450 isoenzymes, not by inflammasome activation.

  • Authors : Xie Y; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160, USA.; Williams CD

Subjects: Cytochrome P-450 Enzyme Inhibitors*; Acetaminophen/Acetaminophen/Acetaminophen/*toxicity ; Chemical and Drug Induced Liver Injury/Chemical and Drug Induced Liver Injury/Chemical and Drug Induced Liver Injury/*prevention & control

  • Source: Toxicological sciences : an official journal of the Society of Toxicology [Toxicol Sci] 2013 Jan; Vol. 131 (1), pp. 325-35. Date of Electronic Publication: 2012 Sep 17.Publisher: Oxford University Press Country of Publication: United States NLM ID: 9805461 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Hepatotoxicity of Herbal Supplements Mediated by Modulation of Cytochrome P450.

  • Authors : Brewer CT; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. .; Integrated Biomedical Sciences Program, University of Tennessee Health Science Center, Memphis, TN 38163, USA. .

Subjects: Herb-Drug Interactions*; Chemical and Drug Induced Liver Injury/Chemical and Drug Induced Liver Injury/Chemical and Drug Induced Liver Injury/*etiology ; Cytochrome P-450 Enzyme Inhibitors/Cytochrome P-450 Enzyme Inhibitors/Cytochrome P-450 Enzyme Inhibitors/*pharmacology

  • Source: International journal of molecular sciences [Int J Mol Sci] 2017 Nov 08; Vol. 18 (11). Date of Electronic Publication: 2017 Nov 08.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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  • 1-10 of  63 results for ""Cytochrome P-450 Enzyme Inhibitors""