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Academic Journal

Design, synthesis and biological activity of α-nitrile substituted guaiazulene-based chalcone derivatives.

  • Authors : Zhang W; Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China; Laboratory for Marine Drugs and Bioproducts, Pilot National Laboratory for Marine Science and Technology, Qingdao 266237, China.

Subjects: Azulenes*/Azulenes*/Azulenes*/pharmacology ; Azulenes*/Azulenes*/Azulenes*/chemistry ; Azulenes*/Azulenes*/Azulenes*/chemical synthesis

  • Source: Fitoterapia [Fitoterapia] 2024 Oct; Vol. 178, pp. 106151. Date of Electronic Publication: 2024 Aug 06.Publisher: Elsevier Country of Publication: Netherlands NLM ID: 16930290R Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Advances in chalcone-based anticancer therapy: mechanisms, preclinical advances, and future perspectives.

  • Authors : Chowdhary S; Department of Chemistry, Guru Nanak Dev University, Amritsar, India.; Preeti

Subjects: Neoplasms*/Neoplasms*/Neoplasms*/drug therapy ; Antineoplastic Agents*/Antineoplastic Agents*/Antineoplastic Agents*/pharmacology ; Chalcones*/Chalcones*/Chalcones*/pharmacology

  • Source: Expert opinion on drug discovery [Expert Opin Drug Discov] 2024 Dec; Vol. 19 (12), pp. 1417-1437. Date of Electronic Publication: 2024 Dec 05.Publisher: Taylor & Francis Country of Publication: England NLM ID: 101295755 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Synthesis, molecular docking, ADMET, and evaluation of the anxiolytic effect in adult zebrafish of synthetic chalcone (E)-3-(4-(dimethylamino)phenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one: An in vivo and in silico approach.

Subjects: Anti-Anxiety Agents*/Anti-Anxiety Agents*/Anti-Anxiety Agents*/pharmacology ; Chalcone* ; Chalcones*

  • Source: Fundamental & clinical pharmacology [Fundam Clin Pharmacol] 2024 Apr; Vol. 38 (2), pp. 290-306. Date of Electronic Publication: 2023 Oct 16.Publisher: Blackwell Science Country of Publication: England NLM ID: 8710411 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

A Review of Experimental Studies on Natural Chalcone-Based Therapeutic Targeting of Genes and Signaling Pathways in Type 2 Diabetes Complications.

  • Authors : Alsharairi NA; Heart, Mind and Body Research Group, Griffith University, Gold Coast, QLD 4222, Australia.

Subjects: Diabetes Mellitus, Type 2*/Diabetes Mellitus, Type 2*/Diabetes Mellitus, Type 2*/drug therapy ; Diabetes Mellitus, Type 2*/Diabetes Mellitus, Type 2*/Diabetes Mellitus, Type 2*/metabolism ; Diabetes Mellitus, Type 2*/Diabetes Mellitus, Type 2*/Diabetes Mellitus, Type 2*/complications

  • Source: Genes [Genes (Basel)] 2024 Jul 18; Vol. 15 (7). Date of Electronic Publication: 2024 Jul 18.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101551097 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4425

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Academic Journal

The Induction of G2/M Phase Cell Cycle Arrest and Apoptosis by the Chalcone Derivative 1C in Sensitive and Resistant Ovarian Cancer Cells Is Associated with ROS Generation.

  • Authors : Salanci Š; Department of Pharmacology, Faculty of Medicine, Pavol Jozef Šafárik University, 040 01 Košice, Slovakia.; Vilková M

Subjects: Reactive Oxygen Species*/Reactive Oxygen Species*/Reactive Oxygen Species*/metabolism ; Apoptosis*/Apoptosis*/Apoptosis*/drug effects ; Ovarian Neoplasms*/Ovarian Neoplasms*/Ovarian Neoplasms*/metabolism

  • Source: International journal of molecular sciences [Int J Mol Sci] 2024 Jul 09; Vol. 25 (14). Date of Electronic Publication: 2024 Jul 09.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

Naringenin chalcone carbon double-bond reductases mediate dihydrochalcone biosynthesis in apple leaves.

  • Authors : Yauk YK; The New Zealand Institute for Plant and Food Research Limited (Plant and Food Research), Auckland 1142, New Zealand.; Dare AP

Subjects: Malus*/Malus*/Malus*/genetics ; Malus*/Malus*/Malus*/metabolism ; Malus*/Malus*/Malus*/enzymology

  • Source: Plant physiology [Plant Physiol] 2024 Dec 02; Vol. 196 (4), pp. 2768-2783.Publisher: American Society of Plant Biologists Country of Publication: United States NLM ID: 0401224 Publication Model: Print Cited Medium: Internet

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Academic Journal

Synergistic Antibacterial Activity of Gallic Acid Based Chalcone Indl 2 by Inhibiting Efflux Pump Transporters.

  • Authors : Dwivedi GR; Biotechnology Division, CSIR-Central Institute of Medicinal and Aromatic Plants, Near Kukrail Picnic Spot, P.O. CIMAP, Lucknow, 226015, India.; Microbiology Department, ICMR-Regional Medical Research Centre, Gorakhpur, 273013, U.P., India.

Subjects: Chalcone*/Chalcone*/Chalcone*/pharmacology ; Chalcones*/Chalcones*/Chalcones*/pharmacology; Escherichia coli

  • Source: Chemistry & biodiversity [Chem Biodivers] 2024 Apr; Vol. 21 (4), pp. e202301820. Date of Electronic Publication: 2024 Mar 13.Publisher: Verlag Helvetica Chimica Acta Country of Publication: Switzerland NLM ID: 101197449 Publication Model: Print-Electronic Cited Medium:

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Academic Journal

A Promising Drug Candidate as Potent Therapeutic Approach for Neuroinflammation and Its In Silico Justification of Chalcone Congeners: a Comprehensive Review.

  • Authors : Karati D; Department of Pharmaceutical Technology, School of Pharmacy, Techno India University, Kolkata, West Bengal, 700091, India.; Mukherjee S

Subjects: Chalcone*/Chalcone*/Chalcone*/pharmacology ; Chalcones*/Chalcones*/Chalcones*/pharmacology; Humans

  • Source: Molecular neurobiology [Mol Neurobiol] 2024 Apr; Vol. 61 (4), pp. 1873-1891. Date of Electronic Publication: 2023 Oct 06.Publisher: Humana Press Country of Publication: United States NLM ID: 8900963 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Synthesis of chalcone derivatives by Claisen-Schmidt condensation and in vitro analyses of their antiprotozoal activities.

  • Authors : Souza GB; Departamento de Química, Universidade Federal de Sergipe, São Cristóvão, SE, Brasil.; Santos TAC

Subjects: Chalcone* ; Chalcones*/Chalcones*/Chalcones*/pharmacology ; Antiprotozoal Agents*/Antiprotozoal Agents*/Antiprotozoal Agents*/pharmacology

  • Source: Natural product research [Nat Prod Res] 2024 Apr; Vol. 38 (8), pp. 1326-1333. Date of Electronic Publication: 2022 Nov 04.Publisher: Taylor & Francis Health Sciences Country of Publication: England NLM ID: 101167924 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

The effects of a chalcone derivative on memory, hippocampal corticosterone and BDNF levels in adult rats.

Subjects: Chalcone*/Chalcone*/Chalcone*/pharmacology ; Chalcones*/Chalcones*/Chalcones*/pharmacology; Male

  • Source: The International journal of neuroscience [Int J Neurosci] 2024 Jun; Vol. 134 (3), pp. 214-223. Date of Electronic Publication: 2022 Jul 21.Publisher: Informa Healthcare Country of Publication: England NLM ID: 0270707 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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