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Academic Journal

A NOTCH2 pathogenic variant and HES1 regulate osteoclastogenesis in induced pluripotent stem cells.

  • Authors : Canalis E; Department of Orthopaedic Surgery, UConn Health, Farmington, CT, USA; Department of Medicine, UConn Health, Farmington, CT, USA

Subjects: Receptor, Notch2*/Receptor, Notch2*/Receptor, Notch2*/metabolism ; Receptor, Notch2*/Receptor, Notch2*/Receptor, Notch2*/genetics ; Induced Pluripotent Stem Cells*/Induced Pluripotent Stem Cells*/Induced Pluripotent Stem Cells*/metabolism

  • Source: Bone [Bone] 2025 Feb; Vol. 191, pp. 117334. Date of Electronic Publication: 2024 Nov 19.Publisher: Elsevier Science Country of Publication: United States NLM ID: 8504048 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

MicroRNA-124a promoted the differentiation of bone marrow mesenchymal stem cells into neurons through Notch signal pathway.

  • Authors : Wang D; Department of Neurology, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, No. 19 Xiuhua Road, Xiuying District, Haikou, 570311, Hainan, China.; Jing L

Subjects: Mesenchymal Stem Cells*/Mesenchymal Stem Cells*/Mesenchymal Stem Cells*/metabolism ; Mesenchymal Stem Cells*/Mesenchymal Stem Cells*/Mesenchymal Stem Cells*/drug effects ; MicroRNAs*/MicroRNAs*/MicroRNAs*/genetics

  • Source: European journal of medical research [Eur J Med Res] 2024 Sep 28; Vol. 29 (1), pp. 472. Date of Electronic Publication: 2024 Sep 28.Publisher: BioMed Central Country of Publication: England NLM ID: 9517857 Publication Model: Electronic Cited Medium: Internet ISSN: 2047-783X

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Academic Journal

Hes1 marks peri-condensation mesenchymal cells that generate both chondrocytes and perichondrial cells in early bone development.

  • Authors : Matsushita Y; Department of Diagnostic and Biomedical Sciences, University of Texas Health Science Center at Houston School of Dentistry, Houston, Texas, USA; Department of Cell Biology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.

Subjects: Bone and Bones*/Bone and Bones*/Bone and Bones*/cytology ; Bone Development* ; Cartilage*/Cartilage*/Cartilage*/cytology

  • Source: The Journal of biological chemistry [J Biol Chem] 2023 Jun; Vol. 299 (6), pp. 104805. Date of Electronic Publication: 2023 May 11.Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication

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Academic Journal

Hes1 overexpression leads to expansion of embryonic neural stem cell pool and stem cell reservoir in the postnatal brain.

  • Authors : Ohtsuka T; Institute for Frontier Life and Medical Sciences, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan .; Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan.

Subjects: Gene Expression*; Cell Differentiation/Cell Differentiation/Cell Differentiation/*genetics ; Embryonic Stem Cells/Embryonic Stem Cells/Embryonic Stem Cells/*metabolism

  • Source: Development (Cambridge, England) [Development] 2021 Feb 17; Vol. 148 (4). Date of Electronic Publication: 2021 Feb 17.Publisher: Company Of Biologists Limited Country of Publication: England NLM ID: 8701744 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

The Notch signaling pathway controls CD8+ T cell differentiation independently of the classical effector HES1.

  • Authors : De Sousa DM; Maisonneuve-Rosemont Hospital Research Center, Montréal, Québec, Canada.; Département de microbiologie, infectiologie et immunologie, Université de Montréal, Montréal, Québec, Canada.

Subjects: CD8-Positive T-Lymphocytes/CD8-Positive T-Lymphocytes/CD8-Positive T-Lymphocytes/*immunology ; Cell Differentiation/Cell Differentiation/Cell Differentiation/*immunology ; Receptors, Notch/Receptors, Notch/Receptors, Notch/*immunology

  • Source: PloS one [PLoS One] 2019 Apr 05; Vol. 14 (4), pp. e0215012. Date of Electronic Publication: 2019 Apr 05 (Print Publication: 2019).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet

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Academic Journal

Hairy and enhancer of split 1 is a primary effector of NOTCH2 signaling and induces osteoclast differentiation and function.

  • Authors : Yu J; Department of Orthopaedic Surgery, UConn Health, Farmington, Connecticut, USA; UConn Musculoskeletal Institute, UConn Health, Farmington, Connecticut, USA.

Subjects: Cell Differentiation/Cell Differentiation/Cell Differentiation/*physiology ; Osteoclasts/Osteoclasts/Osteoclasts/*cytology ; Receptor, Notch2/Receptor, Notch2/Receptor, Notch2/*metabolism

  • Source: The Journal of biological chemistry [J Biol Chem] 2021 Dec; Vol. 297 (6), pp. 101376. Date of Electronic Publication: 2021 Nov 03.Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication

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Editorial & Opinion

The NOTCH-HES-1 axis is involved in promoting Th22 cell differentiation.

  • Authors : Zeng C; Medical Research Center, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde), Foshan, 528300, China. .; Shao Z

Subjects: Signal Transduction*; Cell Differentiation/Cell Differentiation/Cell Differentiation/*immunology ; Interleukins/Interleukins/Interleukins/*metabolism

  • Source: Cellular & molecular biology letters [Cell Mol Biol Lett] 2021 Feb 23; Vol. 26 (1), pp. 7. Date of Electronic Publication: 2021 Feb 23.Publisher: BioMed Central Country of Publication: England NLM ID: 9607427 Publication Model: Electronic Cited Medium: Internet ISSN: 1689-1392

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Academic Journal

Hes1 expression in mature neurons in the adult mouse brain is required for normal behaviors.

  • Authors : Matsuzaki T; Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, 606-8507, Japan.; Graduate School of Medicine, Kyoto University, Kyoto, 606-8501, Japan.

Subjects: Behavior, Animal* ; Cell Differentiation*; Aging/Aging/Aging/*metabolism

  • Source: Scientific reports [Sci Rep] 2019 Jun 03; Vol. 9 (1), pp. 8251. Date of Electronic Publication: 2019 Jun 03.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Alteration in MicroRNA Expression Governs the Nature and Timing of Cellular Fate Commitment.

  • Authors : Sengupta D; Department of Chemistry , IIT Bombay , Powai, Mumbai 400076 , India.; Kar S

Subjects: Cell Differentiation/Cell Differentiation/Cell Differentiation/*genetics ; Gene Expression Regulation, Developmental/Gene Expression Regulation, Developmental/Gene Expression Regulation, Developmental/*genetics ; MicroRNAs/MicroRNAs/MicroRNAs/*genetics

  • Source: ACS chemical neuroscience [ACS Chem Neurosci] 2018 Apr 18; Vol. 9 (4), pp. 725-737. Date of Electronic Publication: 2017 Dec 13.Publisher: American Chemical Society Country of Publication: United States NLM ID: 101525337 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Kynurenine promotes the goblet cell differentiation of HT-29 colon carcinoma cells by modulating Wnt, Notch and AhR signals.

  • Authors : Park JH; Department of Biology, Changwon National University, Changwon, Kyungnam 51140, Republic of Korea.; Lee JM

Subjects: Basic Helix-Loop-Helix Transcription Factors/Basic Helix-Loop-Helix Transcription Factors/Basic Helix-Loop-Helix Transcription Factors/*genetics ; Cell Differentiation/Cell Differentiation/Cell Differentiation/*drug effects ; Colonic Neoplasms/Colonic Neoplasms/Colonic Neoplasms/*drug therapy

  • Source: Oncology reports [Oncol Rep] 2018 Apr; Vol. 39 (4), pp. 1930-1938. Date of Electronic Publication: 2018 Feb 13.Publisher: D.A. Spandidos Country of Publication: Greece NLM ID: 9422756 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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  • 1-10 of  130 results for ""Transcription Factor HES-1""