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Academic Journal

The stem cell-supporting small molecule UM171 triggers Cul3-KBTBD4-mediated degradation of ELM2 domain-harboring proteins.

  • Authors : Žemaitis K; Division of Molecular Medicine and Gene Therapy, Lund Stem Cell Center, Lund University, Lund, Sweden.; Ghosh S

Subjects: Hematopoietic Stem Cells*/Hematopoietic Stem Cells*/Hematopoietic Stem Cells*/cytology ; Hematopoietic Stem Cells*/Hematopoietic Stem Cells*/Hematopoietic Stem Cells*/drug effects ; Hematopoietic Stem Cells*/Hematopoietic Stem Cells*/Hematopoietic Stem Cells*/metabolism

  • Source: The Journal of biological chemistry [J Biol Chem] 2023 May; Vol. 299 (5), pp. 104662. Date of Electronic Publication: 2023 Mar 29.Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication

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Academic Journal

RNF217 regulates iron homeostasis through its E3 ubiquitin ligase activity by modulating ferroportin degradation.

  • Authors : Jiang L; The First Affiliated Hospital, School of Public Health, Institute of Translational Medicine, State Key Laboratory of Experimental Hematology, Zhejiang University School of Medicine, Hangzhou, China.; The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, China.

Subjects: Proteolysis* ; Ubiquitination*; Carrier Proteins/Carrier Proteins/Carrier Proteins/*metabolism

  • Source: Blood [Blood] 2021 Aug 26; Vol. 138 (8), pp. 689-705.Publisher: Elsevier Country of Publication: United States NLM ID: 7603509 Publication Model: Print Cited Medium: Internet ISSN: 1528-0020

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Academic Journal

The endosomal RIN2/Rab5C machinery prevents VEGFR2 degradation to control gene expression and tip cell identity during angiogenesis.

  • Authors : Kempers L; Sanquin Research, Plesmanlaan 125, 1066 CX, Amsterdam, The Netherlands.; Wakayama Y

Subjects: Gene Expression Regulation* ; Neovascularization, Physiologic* ; Proteolysis*

  • Source: Angiogenesis [Angiogenesis] 2021 Aug; Vol. 24 (3), pp. 695-714. Date of Electronic Publication: 2021 May 13.Publisher: Springer Country of Publication: Germany NLM ID: 9814575 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-7209

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Academic Journal

The CDC37-HSP90 chaperone complex co-translationally degrades the nascent kinase-dead mutant of HIPK2.

  • Authors : Müller JP; Institut für Biochemie, Westfälische-Wilhelms-Universität Münster, Germany.; Klempnauer KH

Subjects: Protein Biosynthesis* ; Proteolysis*; Carrier Proteins/Carrier Proteins/Carrier Proteins/*metabolism

  • Source: FEBS letters [FEBS Lett] 2021 Jun; Vol. 595 (11), pp. 1559-1568. Date of Electronic Publication: 2021 May 06.Publisher: John Wiley & Sons Ltd Country of Publication: England NLM ID: 0155157 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Proteasomal degradation of the tumour suppressor FBW7 requires branched ubiquitylation by TRIP12.

  • Authors : Khan OM; Adult Stem Cell Laboratory, The Francis Crick Institute, London, UK. .; Hamad Bin Khalifa University, College of Health and Life Sciences Qatar Foundation, Education City, Education City, Doha, Qatar. .

Subjects: Proteolysis* ; Ubiquitination*; Carrier Proteins/Carrier Proteins/Carrier Proteins/*metabolism

  • Source: Nature communications [Nat Commun] 2021 Apr 06; Vol. 12 (1), pp. 2043. Date of Electronic Publication: 2021 Apr 06.Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

TRIP12 promotes small-molecule-induced degradation through K29/K48-branched ubiquitin chains.

  • Authors : Kaiho-Soma A; Institute for Advanced Life Sciences, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan.; Akizuki Y

Subjects: Proteolysis*; Carrier Proteins/Carrier Proteins/Carrier Proteins/*metabolism ; Polyubiquitin/Polyubiquitin/Polyubiquitin/*metabolism

  • Source: Molecular cell [Mol Cell] 2021 Apr 01; Vol. 81 (7), pp. 1411-1424.e7. Date of Electronic Publication: 2021 Feb 09.Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Expression of protein kinase HIPK2 is subject to a quality control mechanism that acts during translation and requires its kinase activity to prevent degradation of nascent HIPK2.

  • Authors : Müller JP; Institut für Biochemie, Westfälische-Wilhelms-Universität Münster, Wilhelm-Klemm-Str. 2, D-48149 Münster, Germany.; Scholl S

Subjects: Protein Biosynthesis* ; Proteolysis*; Carrier Proteins/Carrier Proteins/Carrier Proteins/*genetics

  • Source: Biochimica et biophysica acta. Molecular cell research [Biochim Biophys Acta Mol Cell Res] 2021 Jan; Vol. 1868 (1), pp. 118894. Date of Electronic Publication: 2020 Oct 19.Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101731731 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Structural basis of ER-associated protein degradation mediated by the Hrd1 ubiquitin ligase complex.

  • Authors : Wu X; Howard Hughes Medical Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.; Siggel M

Subjects: Endoplasmic Reticulum-Associated Degradation* ; Proteolysis*; Carrier Proteins/Carrier Proteins/Carrier Proteins/*chemistry

  • Source: Science (New York, N.Y.) [Science] 2020 Apr 24; Vol. 368 (6489).Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print Cited Medium:

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Academic Journal

RBX1 prompts degradation of EXO1 to limit the homologous recombination pathway of DNA double-strand break repair in G1 phase.

  • Authors : Xie Y; Department of Radiation Toxicology and Oncology, Beijing Institute of Radiation Medicine, 100850, Beijing, China.; Key Laboratory of Molecular Epidemiology of Hunan Province, School of Medicine, Hunan Normal University, 410013, Changsha, China.

Subjects: DNA Breaks, Double-Stranded* ; DNA Repair* ; G1 Phase*

  • Source: Cell death and differentiation [Cell Death Differ] 2020 Apr; Vol. 27 (4), pp. 1383-1397. Date of Electronic Publication: 2019 Sep 27.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9437445 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Structural modeling defines transmembrane residues in ADAM17 that are crucial for Rhbdf2-ADAM17-dependent proteolysis.

  • Authors : Li X; Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, New York, NY 10021, USA.; Dept. of Biochemistry, Cellular and Molecular Biology, Weill Cornell Medicine, New York, NY 10021, USA.

Subjects: Models, Molecular* ; Proteolysis*; ADAM17 Protein/ADAM17 Protein/ADAM17 Protein/*chemistry

  • Source: Journal of cell science [J Cell Sci] 2017 Mar 01; Vol. 130 (5), pp. 868-878. Date of Electronic Publication: 2017 Jan 19.Publisher: Company of Biologists Country of Publication: England NLM ID: 0052457 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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  • 1-10 of  4,027 results for ""Proteolysis""