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Addressing the Evolution of Cardenolide Formation in Iridoid-Synthesizing Plants: Site-Directed Mutagenesis of PRISEs (Progesterone-5β-Reductase/Iridoid Synthase-like Enzymes) of Plantago Species.

• Authors : Dorfner M; Friedrich-Alexander-Universität Erlangen-Nürnberg, Department of Biology, Pharmaceutical Biology, Staudtstraße 5, 91058 Erlangen, Germany.; Klein J

Subjects: Mutagenesis, Site-Directed* ; Plantago*/Plantago*/Plantago*/genetics ; Plantago*/Plantago*/Plantago*/metabolism

• Source: Molecules (Basel, Switzerland) [Molecules] 2024 Dec 07; Vol. 29 (23). Date of Electronic Publication: 2024 Dec 07.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049

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Research Progress on Plant-Derived Cardenolides (2010-2023).

• Authors : He YL; Research Institute, Lanzhou Jiaotong University, Lanzhou, 730070, People's Republic of China.; State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, People's Republic of China.

Subjects: Cardenolides*/Cardenolides*/Cardenolides*/chemistry ; Cardenolides*/Cardenolides*/Cardenolides*/pharmacology ; Cardenolides*/Cardenolides*/Cardenolides*/isolation & purification

• Source: Chemistry & biodiversity [Chem Biodivers] 2024 Dec; Vol. 21 (12), pp. e202401460. Date of Electronic Publication: 2024 Oct 18.Publisher: Verlag Helvetica Chimica Acta Country of Publication: Switzerland NLM ID: 101197449 Publication Model: Print-Electronic Cited Medium:

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Heat waves induce milkweed resistance to a specialist herbivore via increased toxicity and reduced nutrient content.

• Authors : López‐Goldar, Xosé^1,2,3 (AUTHOR) ; Mollema, Alyssa² (AUTHOR); Sivak‐Schwennesen, Caz² (AUTHOR)

Subjects: *INSECT physiology; *MONARCH butterfly; *CLIMATE extremes

• Source: Plant, Cell & Environment. Dec2024, Vol. 47 Issue 12, p4530-4542. 13p.

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Substrate Specificity of ABCB Transporters Predicted by Docking Simulations Can Be Confirmed by Experimental Tests.

• Authors : Röpcke, Mario¹ (AUTHOR) ; Lu, Sha¹ (AUTHOR); Plate, Cäcilia¹ (AUTHOR)

Subjects: *STEROID glycosides; *METABOLITES; *CARDENOLIDES

• Source: Molecules. Nov2024, Vol. 29 Issue 22, p5272. 27p.

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Potent Nitrogen-containing Milkweed Toxins are Differentially Regulated by Soil Nitrogen and Herbivore-induced Defense.

• Authors : Agrawal AA; Department of Ecology and Evolutionary Biology, Cornell University, Ithaca, NY, 14853, USA. .; Department of Entomology, Cornell University, Ithaca, NY, 14853, USA. .

Subjects: Asclepias*/Asclepias*/Asclepias*/chemistry ; Asclepias*/Asclepias*/Asclepias*/metabolism ; Butterflies*/Butterflies*/Butterflies*/physiology

• Source: Journal of chemical ecology [J Chem Ecol] 2024 Nov; Vol. 50 (11), pp. 725-737. Date of Electronic Publication: 2024 Oct 29.Publisher: Springer Country of Publication: United States NLM ID: 7505563 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Biotransformation of Cardenolides from Calotropis procera and Their Cytotoxic Potential against Human Mammary Gland Carcinoma Cells.

• Authors : Kiran, R. Kharat^1,2 ; Vinod, R. Ragade¹; Amol, R. Kharat³

Subjects: *CALOTROPIS procera; *LIQUID chromatography-mass spectrometry; *CARDENOLIDES

• Source: Agricultural Science Digest. Oct2024, Vol. 44 Issue 5, p930-937. 8p.

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Progesterone Metabolism in Digitalis and Other Plants—60 Years of Research and Recent Results.

• Authors : Klein, Jan¹ (AUTHOR)

Subjects: *SUPRAVENTRICULAR tachycardia; *HEART failure; *BOTANISTS

• Source: Plant & Cell Physiology. Oct2024, Vol. 65 Issue 10, p1500-1514. 15p.

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Agricola

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Integrated GC-MS and UPLC-ESI-QTOF-MS based untargeted metabolomics analysis of in vitro raised tissues of Digitalis purpurea L.

• Authors : Yashika Bansal; Mujib, A.; Mamgain, Jyoti

Subjects: ROSMARINIC acid; GAS chromatography/Mass spectrometry (GC-MS); METABOLOMIC fingerprinting

• Source: Frontiers in Plant Science; 2024, p01-29, 29p

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Cardenolide glycosides sensitize gefitinib-induced apoptosis in non-small cell lung cancer: inhibition of Na + /K + -ATPase serving as a switch-on mechanism.

• Authors : Du CM; School of Pharmacy, National Taiwan University, No. 33, Linsen S. Rd., Zhongzheng Dist, Taipei, 100, Taiwan.; Leu WJ

Subjects: Carcinoma, Non-Small-Cell Lung*/Carcinoma, Non-Small-Cell Lung*/Carcinoma, Non-Small-Cell Lung*/drug therapy ; Carcinoma, Non-Small-Cell Lung*/Carcinoma, Non-Small-Cell Lung*/Carcinoma, Non-Small-Cell Lung*/pathology ; Carcinoma, Non-Small-Cell Lung*/Carcinoma, Non-Small-Cell Lung*/Carcinoma, Non-Small-Cell Lung*/metabolism

• Source: Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2024 Sep; Vol. 397 (9), pp. 6533-6550. Date of Electronic Publication: 2024 Mar 07.Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0326264 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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