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E3 ubiquitin ligase HECW1 promotes the metastasis of non-small cell lung cancer cells through mediating the ubiquitination of Smad4.

• Authors : Lu, Chen; Ning, Guangyao; Si, Panpan

Subjects: NON-small-cell lung carcinoma; UBIQUITIN ligases; UBIQUITINATION

• Source: Biochemistry & Cell Biology. 2021, Vol. 99 Issue 5, p675-681. 7p.

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Citrullinating enzyme PADI4 and transcriptional repressor RING1B bind in cancer cells.

• Authors : Araujo-Abad, Salome^1,2 (AUTHOR) ; Rizzuti, Bruno^3,4 (AUTHOR); Soto-Conde, Lourdes² (AUTHOR)

Subjects: *UBIQUITIN ligases; *ISOTHERMAL titration calorimetry; *CANCER cells

• Source: International Journal of Biological Macromolecules. Aug2024:Part 1, Vol. 274, pN.PAG-N.PAG. 1p.

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RNF43 Inactivation Enhances the B‐RAF/MEK Signaling and Creates a Combinatory Therapeutic Target in Cancer Cells.

• Authors : Hsu, Shih‐Han¹ (AUTHOR); Tsai, Ya‐Li¹ (AUTHOR); Wang, Yeng‐Tseng² (AUTHOR)

Subjects: *CANCER cells; *UBIQUITIN ligases; *PANCREATIC tumors

• Source: Advanced Science. 3/27/2024, Vol. 11 Issue 12, p1-15. 15p.

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Metformin Suppresses Both PD-L1 Expression in Cancer Cells and Cancer-Induced PD-1 Expression in Immune Cells to Promote Antitumor Immunity.

• Authors : Su Hwan Park; Juheon Le; Hye Jin Yun

Subjects: PROGRAMMED cell death 1 receptors; PROGRAMMED death-ligand 1; CANCER cells

• Source: Annals of Laboratory Medicine; Sep2024, Vol. 44 Issue 5, p426-436, 11p

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The role of NEDD4 related HECT-type E3 ubiquitin ligases in defective autophagy in cancer cells: molecular mechanisms and therapeutic perspectives.

• Authors : Zhang, Rui¹ (AUTHOR); Shi, Shaoqing² (AUTHOR)

Subjects: *UBIQUITIN ligases; *CANCER cells; *AUTOPHAGY

• Source: Molecular Medicine. 3/14/2023, Vol. 29 Issue 1, p1-17. 17p.

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The deubiquitinase ZRANB1 is an E3 ubiquitin ligase for SLC7A11 and regulates ferroptotic resistance.

• Authors : Shan Huang¹; Qimin Zhang¹; Manyu Zhao¹

Subjects: *GLUTAMATE transporters; *UBIQUITIN ligases; *CATALYTIC domains

• Source: Journal of Cell Biology. 11/6/2023, Vol. 222 Issue 11, p1-16. 24p.

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Biotinylation of an acetylenic tricyclic bis(cyanoenone) lowers its potency as an NRF2 activator while creating a novel activity against BACH1.

• Authors : Moreno, Rita¹ (AUTHOR); Casares, Laura¹ (AUTHOR); Higgins, Maureen¹ (AUTHOR)

Subjects: *NUCLEAR factor E2 related factor; *UBIQUITIN ligases; *TRANSCRIPTION factors

• Source: Free Radical Biology & Medicine. Oct2022, Vol. 191, p203-211. 9p.

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A molecular glue RBM39-degrader induces synthetic lethality in cancer cells with homologous recombination repair deficiency.

• Authors : Kohsaka, Shinji; Yagishita, Shigehiro; Shirai, Yukina

Subjects: HOMOLOGOUS recombination; CANCER cells; DOUBLE-strand DNA breaks

• Source: NPJ Precision Oncology; 5/24/2024, Vol. 8 Issue 1, p1-11, 11p

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Oncogene-Stimulated Congestion at the KEAP1 Stress Signaling Hub Allows Bypass of NRF2 and Induction of NRF2-Target Genes that Promote Tumor Survival.

• Authors : Hayes, John D.¹; Dinkova-Kostova, Albena T.¹

Subjects: *ONCOGENES; *UBIQUITIN ligases; *CANCER cells

• Source: Cancer Cell. Nov2017, Vol. 32 Issue 5, p539-541. 3p.

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Researchers at University of Manitoba Describe Findings in Medulloblastoma (Ubiquitin ligases and medulloblastoma: genetic markers of the four consensus subgroups identified through transcriptome datasets)

• Source: Obesity, Fitness & Wellness Week. June 13, 2020, 5531

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