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Academic Journal

EGFR‐mediated hyperacetylation of tubulin induced docetaxel resistance by downregulation of HDAC6 and upregulation of MCAK and PLK1 in prostate cancer cells.

Subjects: TUBULINS; DOCETAXEL; EPIDERMAL growth factor receptors

  • Source: Kaohsiung Journal of Medical Sciences; Jan2024, Vol. 40 Issue 1, p23-34, 12p

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Hit Identification and Functional Validation of Novel Dual Inhibitors of HDAC8 and Tubulin Identified by Combining Docking and Molecular Dynamics Simulations.

Subjects: MOLECULAR dynamics; MOLECULAR docking; CELL survival

  • Source: Antioxidants; Nov2024, Vol. 13 Issue 11, p1427, 21p

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Academic Journal

A Novel Pyrazole Exhibits Potent Anticancer Cytotoxicity via Apoptosis, Cell Cycle Arrest, and the Inhibition of Tubulin Polymerization in Triple-Negative Breast Cancer Cells.

Subjects: TRIPLE-negative breast cancer; CELL cycle; MOLECULAR docking

  • Source: Cells (2073-4409); Jul2024, Vol. 13 Issue 14, p1225, 19p

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Academic Journal

Discovery of potent tubulin inhibitors targeting the colchicine binding site via structure-based lead optimization and antitumor evaluation.

Subjects: *TUBULINS; *BINDING sites; *COLCHICINE

  • Source: Journal of Enzyme Inhibition & Medicinal Chemistry. Dec2023, Vol. 38 Issue 1, p1-18. 18p.

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Academic Journal

Antiproliferative and Pro-Apoptotic Activity and Tubulin Dynamics Modulation of 1 H -Benzimidazol-2-yl Hydrazones in Human Breast Cancer Cell Line MDA-MB-231.

Subjects: TUBULINS; BREAST cancer; CELL lines

  • Source: Molecules; May2024, Vol. 29 Issue 10, p2400, 17p

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Academic Journal

A potent Bioorganic azapodophyllotoxin derivative Suppresses tumor Progression in Triple negative breast Cancer: An Insight into its Inhibitory effect on tubulin polymerization and Disruptive effect on microtubule assembly.

Subjects: *TRIPLE-negative breast cancer; *TUBULINS; *CELL survival

  • Source: Bioorganic Chemistry. Dec2024, Vol. 153, pN.PAG-N.PAG. 1p.

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Academic Journal

Synthesis, biological evaluation, and molecular modelling of new naphthalene-chalcone derivatives as potential anticancer agents on MCF-7 breast cancer cells by targeting tubulin colchicine binding site.

Subjects: *CHALCONE; *TUBULINS; *BINDING sites

  • Source: Journal of Enzyme Inhibition & Medicinal Chemistry. Dec2020, Vol. 35 Issue 1, p139-144. 6p.

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Academic Journal

Δ3-tubulin impairs mitotic spindle morphology and increases nuclear size in pancreatic cancer cells.

Subjects: TUBULINS; SPINDLE apparatus; PANCREATIC cancer

  • Source: Medical Molecular Morphology; Mar2024, Vol. 57 Issue 1, p59-67, 9p

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Academic Journal

βIII‐tubulin suppression enhances the activity of Amuvatinib to inhibit cell proliferation in c‐Met positive non‐small cell lung cancer cells.

Subjects: NON-small-cell lung carcinoma; TUBULINS; INHIBITION of cellular proliferation

  • Source: Cancer Medicine; Feb2023, Vol. 12 Issue 4, p4455-4471, 17p

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Academic Journal

Bicyclic isothioureas for conjugation with tubulin targeted anticancer agents.

Subjects: *TUBULINS; *ANTINEOPLASTIC agents; *MOLECULAR structure

  • Source: Mendeleev Communications. Nov2022, Vol. 32 Issue 6, p766-768. 3p.

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  • 1-10 of  8,623 results for ""Tubulin""