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Academic Journal

Protein Kinase A Regulates Platelet Phosphodiesterase 3A through an A-Kinase Anchoring Protein Dependent Manner.

  • Authors : Khalil JS; Leeds Institute of Cardiovascular & Metabolic Medicine, University of Leeds, Leeds LS2 9JT, UK.; Law R

Subjects: Cyclic Nucleotide Phosphodiesterases, Type 3*/Cyclic Nucleotide Phosphodiesterases, Type 3*/Cyclic Nucleotide Phosphodiesterases, Type 3*/metabolism ; Cyclic Nucleotide Phosphodiesterases, Type 3*/Cyclic Nucleotide Phosphodiesterases, Type 3*/Cyclic Nucleotide Phosphodiesterases, Type 3*/genetics ; Blood Platelets*/Blood Platelets*/Blood Platelets*/metabolism

  • Source: Cells [Cells] 2024 Jun 26; Vol. 13 (13). Date of Electronic Publication: 2024 Jun 26.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409

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Academic Journal

Inhibition of Phosphodiesterase 3A by Cilostazol Dampens Proinflammatory Platelet Functions.

  • Authors : Coenen DM; Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, 6229 ER Maastricht, The Netherlands.; Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, Lexington, KY 40506, USA.

Subjects: Anti-Inflammatory Agents/Anti-Inflammatory Agents/Anti-Inflammatory Agents/*pharmacology ; Blood Platelets/Blood Platelets/Blood Platelets/*drug effects ; Cilostazol/Cilostazol/Cilostazol/*pharmacology

  • Source: Cells [Cells] 2021 Aug 05; Vol. 10 (8). Date of Electronic Publication: 2021 Aug 05.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409

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Academic Journal

Protein kinase C-mediated phosphorylation and activation of PDE3A regulate cAMP levels in human platelets.

  • Authors : Hunter RW; Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK.; Mackintosh C

Subjects: Blood Platelets/Blood Platelets/Blood Platelets/*enzymology ; Cyclic AMP/Cyclic AMP/Cyclic AMP/*metabolism ; Cyclic Nucleotide Phosphodiesterases, Type 3/Cyclic Nucleotide Phosphodiesterases, Type 3/Cyclic Nucleotide Phosphodiesterases, Type 3/*metabolism

  • Source: The Journal of biological chemistry [J Biol Chem] 2009 May 01; Vol. 284 (18), pp. 12339-48. Date of Electronic Publication: 2009 Mar 04.Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication

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Academic Journal

Thrombospondin-1 promotes hemostasis through modulation of cAMP signaling in blood platelets.

  • Authors : Aburima A; Centre for Atherothrombosis and Metabolic Disease, Hull York Medical School, University of Hull, Hull, United Kingdom.; Berger M

Subjects: Blood Platelets/Blood Platelets/Blood Platelets/*physiology ; Cyclic AMP/Cyclic AMP/Cyclic AMP/*physiology ; Hemorrhagic Disorders/Hemorrhagic Disorders/Hemorrhagic Disorders/*genetics

  • Source: Blood [Blood] 2021 Feb 04; Vol. 137 (5), pp. 678-689.Publisher: Elsevier Country of Publication: United States NLM ID: 7603509 Publication Model: Print Cited Medium: Internet ISSN: 1528-0020

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Academic Journal

Atherogenic lipid stress induces platelet hyperactivity through CD36-mediated hyposensitivity to prostacyclin: the role of phosphodiesterase 3A.

  • Authors : Berger M; Centre for Cardiovascular and Metabolic Research, Hull York Medical School, University of Hull, Hull, UK.; Department of Internal Medicine 1, University Hospital RWTH Aachen, Aachen, Germany.

Subjects: Blood Platelets* ; Epoprostenol*; Animals

  • Source: Haematologica [Haematologica] 2020 Mar; Vol. 105 (3), pp. 808-819. Date of Electronic Publication: 2019 Jul 09.Publisher: Ferrata Storti Foundation Country of Publication: Italy NLM ID: 0417435 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Protective mechanisms of adenosine 5'-monophosphate in platelet activation and thrombus formation.

Subjects: Adenosine Monophosphate/Adenosine Monophosphate/Adenosine Monophosphate/*metabolism ; Blood Platelets/Blood Platelets/Blood Platelets/*physiology ; Mesenteric Veins/Mesenteric Veins/Mesenteric Veins/*physiology

  • Source: Thrombosis and haemostasis [Thromb Haemost] 2014 Mar 03; Vol. 111 (3), pp. 491-507. Date of Electronic Publication: 2013 Dec 05.Publisher: Thieme Country of Publication: Germany NLM ID: 7608063 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2567-689X

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Academic Journal

Cilostazol, a specific PDE-3 inhibitor, ameliorates chronic ileitis via suppression of interaction of platelets with monocytes.

  • Authors : Matsunaga H; Dept. of Internal Medicine, National Defense Medical College, Saitama, Japan.; Hokari R

Subjects: Phosphodiesterase 3 Inhibitors*; Anti-Inflammatory Agents/Anti-Inflammatory Agents/Anti-Inflammatory Agents/*pharmacology ; Blood Platelets/Blood Platelets/Blood Platelets/*drug effects

  • Source: American journal of physiology. Gastrointestinal and liver physiology [Am J Physiol Gastrointest Liver Physiol] 2009 Dec; Vol. 297 (6), pp. G1077-84. Date of Electronic Publication: Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901227 Publication Model: Print-Electronic Cited Medium:

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Academic Journal

Thrombin regulates intracellular cyclic AMP concentration in human platelets through phosphorylation/activation of phosphodiesterase 3A.

  • Authors : Zhang W; Sol Sherry Thrombosis Research Center, Temple University School of Medicine, Philadelphia, PA 19140, USA.; Colman RW

Subjects: 3',5'-Cyclic-AMP Phosphodiesterases/3',5'-Cyclic-AMP Phosphodiesterases/3',5'-Cyclic-AMP Phosphodiesterases/*metabolism ; Blood Platelets/Blood Platelets/Blood Platelets/*enzymology ; Calcium Signaling/Calcium Signaling/Calcium Signaling/*drug effects

  • Source: Blood [Blood] 2007 Sep 01; Vol. 110 (5), pp. 1475-82. Date of Electronic Publication: 2007 Mar 28.Publisher: Elsevier Country of Publication: United States NLM ID: 7603509 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0006-4971

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Academic Journal

Role of phosphodiesterase type 3A and 3B in regulating platelet and cardiac function using subtype-selective knockout mice.

  • Authors : Sun B; Otsuka Maryland Medicinal Laboratories, Inc, 9900 Medical Center Drive, Rockville, MD 20850, United States.; Li H

Subjects: Gene Expression Regulation, Enzymologic*; 3',5'-Cyclic-AMP Phosphodiesterases/3',5'-Cyclic-AMP Phosphodiesterases/3',5'-Cyclic-AMP Phosphodiesterases/*metabolism ; Blood Platelets/Blood Platelets/Blood Platelets/*metabolism

  • Source: Cellular signalling [Cell Signal] 2007 Aug; Vol. 19 (8), pp. 1765-71. Date of Electronic Publication: 2007 Apr 06.Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 8904683 Publication Model: Print-Electronic Cited Medium: Print ISSN:

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Academic Journal

Leptin-mediated activation of human platelets: involvement of a leptin receptor and phosphodiesterase 3A-containing cellular signaling complex.

  • Authors : Elbatarny HS; Dept. of Pharmacology & Toxicology, Queen's University, Kingston, Ontario, Canada K7L 3N6.; Maurice DH

Subjects: 3',5'-Cyclic-AMP Phosphodiesterases/3',5'-Cyclic-AMP Phosphodiesterases/3',5'-Cyclic-AMP Phosphodiesterases/*metabolism ; Blood Platelets/Blood Platelets/Blood Platelets/*physiology ; Leptin/Leptin/Leptin/*metabolism

  • Source: American journal of physiology. Endocrinology and metabolism [Am J Physiol Endocrinol Metab] 2005 Oct; Vol. 289 (4), pp. E695-702. Date of Electronic Publication: 2005 May 10.Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901226 Publication Model: Print-Electronic Cited Medium:

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