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Academic Journal

Airway tryptase levels inform the lack of clinical efficacy of the tryptase inhibitor MTPS9579A in asthma.

  • Authors : Rhee H; Early Clinical Development, Ophthalmology, Metabolism, Neurology, Immunology (OMNI), Genentech, Inc., South San Francisco, California, USA.; Henderson LM

Subjects: Tryptases*/Tryptases*/Tryptases*/antagonists & inhibitors ; Asthma*/Asthma*/Asthma*/drug therapy; Humans

  • Source: Allergy [Allergy] 2024 Nov; Vol. 79 (11), pp. 2993-3004. Date of Electronic Publication: 2024 Sep 09.Publisher: Wiley-Blackwell Country of Publication: Denmark NLM ID: 7804028 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

The emerging role of mast cell proteases in asthma.

  • Authors : Pejler G; Dept of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden .; Dept of Anatomy, Physiology and Biochemistry, Swedish University of Agricultural Sciences, Uppsala, Sweden.

Subjects: Asthma/Asthma/Asthma/*enzymology ; Carboxypeptidases A/Carboxypeptidases A/Carboxypeptidases A/*metabolism ; Chymases/Chymases/Chymases/*metabolism

  • Source: The European respiratory journal [Eur Respir J] 2019 Oct 31; Vol. 54 (4). Date of Electronic Publication: 2019 Oct 31 (Print Publication: 2019).Publisher: European Respiratory Society Country of Publication: England NLM ID: 8803460 Publication Model: Electronic-Print Cited Medium: Internet

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Academic Journal

Direct effects of mast cell proteases, tryptase and chymase, on bronchial epithelial integrity proteins and anti-viral responses.

  • Authors : Ramu S; Department of Experimental Medical Science, Lund University, Lund, Sweden.; Akbarshahi H

Subjects: Asthma/Asthma/Asthma/*immunology ; Bronchi/Bronchi/Bronchi/*pathology ; Chymases/Chymases/Chymases/*metabolism

  • Source: BMC immunology [BMC Immunol] 2021 Jun 02; Vol. 22 (1), pp. 35. Date of Electronic Publication: 2021 Jun 02.Publisher: BioMed Central Country of Publication: England NLM ID: 100966980 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2172

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Academic Journal

Blood tryptase and thymic stromal lymphopoietin levels predict the risk of exacerbation in severe asthma.

  • Authors : Ko HK; Department of Chest Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, Taipei, 112, Taiwan, ROC.; School of Medicine, National Yang-Ming University, Taipei, Taiwan, ROC.

Subjects: Asthma*/Asthma*/Asthma*/drug therapy ; Asthma*/Asthma*/Asthma*/pathology ; Symptom Flare Up*

  • Source: Scientific reports [Sci Rep] 2021 Apr 19; Vol. 11 (1), pp. 8425. Date of Electronic Publication: 2021 Apr 19.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Characteristics and Treatment of Anaphylaxis in Children Visiting a Pediatric Emergency Department in Korea.

  • Authors : Lee WS; Department of Pediatrics, CHA Ilsan Medical Center, CHA University, Goyang, Republic of Korea.; Pediatric Emergency Department, CHA Ilsan Medical Center, CHA University, Goyang, Republic of Korea.

Subjects: Anaphylaxis/Anaphylaxis/Anaphylaxis/*drug therapy ; Asthma/Asthma/Asthma/*drug therapy ; Epinephrine/Epinephrine/Epinephrine/*administration & dosage

  • Source: BioMed research international [Biomed Res Int] 2020 Feb 27; Vol. 2020, pp. 2014104. Date of Electronic Publication: 2020 Feb 27 (Print Publication: 2020).Publisher: Hindawi Pub. Co Country of Publication: United States NLM ID: 101600173 Publication Model: eCollection Cited Medium: Internet ISSN:

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Academic Journal

An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma.

  • Authors : Maun HR; Department of Early Discovery Biochemistry, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.; Jackman JK

Subjects: Antibodies, Monoclonal, Humanized/Antibodies, Monoclonal, Humanized/Antibodies, Monoclonal, Humanized/*therapeutic use ; Asthma/Asthma/Asthma/*therapy ; Mast Cells/Mast Cells/Mast Cells/*enzymology

  • Source: Cell [Cell] 2019 Oct 03; Vol. 179 (2), pp. 417-431.e19.Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print Cited Medium: Internet ISSN: 1097-4172

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Academic Journal

Mouse mast cell protease-6 and MHC are involved in the development of experimental asthma.

  • Authors : Cui Y; Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.; Dahlin JS

Subjects: Major Histocompatibility Complex*; Asthma/Asthma/Asthma/*immunology ; Bronchial Hyperreactivity/Bronchial Hyperreactivity/Bronchial Hyperreactivity/*immunology

  • Source: Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2014 Nov 15; Vol. 193 (10), pp. 4783-4789. Date of Electronic Publication: 2014 Oct 15.Publisher: American Association of Immunologists Country of Publication: United States NLM ID: 2985117R Publication Model: Print-Electronic Cited Medium:

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Academic Journal

Alpha-tryptase gene variation is associated with levels of circulating IgE and lung function in asthma.

  • Authors : Abdelmotelb AM; Clinical and Experimental Sciences Unit, Faculty of Medicine, University of Southampton, Southampton, UK; Faculty of Medicine, Tanta University, Tanta, Egypt.

Subjects: Genetic Variation*; Asthma/Asthma/Asthma/*etiology ; Asthma/Asthma/Asthma/*physiopathology

  • Source: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology [Clin Exp Allergy] 2014 Jun; Vol. 44 (6), pp. 822-30.Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 8906443 Publication Model: Print Cited Medium: Internet ISSN:

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Academic Journal

Nafamostat mesilate, a potent serine protease inhibitor, inhibits airway eosinophilic inflammation and airway epithelial remodeling in a murine model of allergic asthma.

  • Authors : Ishizaki M; Laboratory of Pharmacology, Department of Bioactive Molecules, Gifu Pharmaceutical University, Gifu, Japan.; Tanaka H

Subjects: Anti-Inflammatory Agents, Non-Steroidal/Anti-Inflammatory Agents, Non-Steroidal/Anti-Inflammatory Agents, Non-Steroidal/*pharmacology ; Asthma/Asthma/Asthma/*drug therapy ; Eosinophils/Eosinophils/Eosinophils/*drug effects

  • Source: Journal of pharmacological sciences [J Pharmacol Sci] 2008 Nov; Vol. 108 (3), pp. 355-63. Date of Electronic Publication: 2008 Nov 14.Publisher: Japanese Pharmacological Society Country of Publication: Japan NLM ID: 101167001 Publication Model: Print-Electronic Cited Medium: Print

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Academic Journal

Potent, nonpeptide inhibitors of human mast cell tryptase. Synthesis and biological evaluation of novel spirocyclic piperidine amide derivatives.

  • Authors : Costanzo MJ; Research and Early Development, Johnson & Johnson Pharmaceutical Research & Development, Welsh & McKean Roads, Spring House, PA 19477-0776, USA. ; Yabut SC

Subjects: Asthma/Asthma/Asthma/*drug therapy ; Respiratory Hypersensitivity/Respiratory Hypersensitivity/Respiratory Hypersensitivity/*drug therapy ; Serine Proteinase Inhibitors/Serine Proteinase Inhibitors/Serine Proteinase Inhibitors/*pharmacology

  • Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2008 Mar 15; Vol. 18 (6), pp. 2114-21. Date of Electronic Publication: 2008 Jan 30.Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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  • 1-10 of  332 results for ""Tryptases""