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Academic Journal

Sulfonamido, amido heterocyclic adducts of tetrazole derivatives as BACE1 inhibitors: in silico exploration.

  • Authors : Joshi N; Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM's NMIMS, V L Mehta Road, Vile Parle West, Mumbai, Maharashtra, 400056, India.; Alavala RR

Subjects: Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/antagonists & inhibitors ; Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/chemistry ; Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/metabolism

  • Source: Molecular diversity [Mol Divers] 2024 Dec; Vol. 28 (6), pp. 4017-4049. Date of Electronic Publication: 2024 Jan 25.Publisher: ESCOM Science Publishers Country of Publication: Netherlands NLM ID: 9516534 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Membrane-Targeted Quantum Dot-Based BACE1 Activity Sensors for In Vitro and In Cellulo Assays.

  • Authors : Tosat-Bitrián C; Centro de Investigaciones Biológicas 'Margarita Salas'-CSIC, Ramiro de Maeztu 9, 28040 Madrid, Spain.; Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas, (CIBERNED), Instituto de Salud Carlos III, Av. Monforte de Lemos, 3-5, 28029 Madrid, Spain.

Subjects: Quantum Dots*/Quantum Dots*/Quantum Dots*/chemistry ; Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/metabolism ; Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/chemistry

  • Source: ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2024 Nov 20; Vol. 16 (46), pp. 63186-63194. Date of Electronic Publication: 2024 Nov 08.Publisher: American Chemical Society Country of Publication: United States NLM ID: 101504991 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Therapeutic Potential of Ramalin Derivatives with Enhanced Stability in the Treatment of Alzheimer's Disease.

  • Authors : Kim TK; Division of Polar Life Sciences, Korea Polar Research Institute, Incheon 21990, Republic of Korea.; Hong JM

Subjects: Alzheimer Disease*/Alzheimer Disease*/Alzheimer Disease*/drug therapy ; Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/antagonists & inhibitors ; Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/metabolism

  • Source: Molecules (Basel, Switzerland) [Molecules] 2024 Nov 05; Vol. 29 (22). Date of Electronic Publication: 2024 Nov 05.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049

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Academic Journal

Virtual screening, ADMET prediction, molecular docking, and dynamic simulation studies of natural products as BACE1 inhibitors for the management of Alzheimer's disease.

  • Authors : Gheidari D; Department of Chemistry, Faculty of Science, University of Guilan, Rasht, Iran. .; Mehrdad M

Subjects: Alzheimer Disease*/Alzheimer Disease*/Alzheimer Disease*/drug therapy ; Alzheimer Disease*/Alzheimer Disease*/Alzheimer Disease*/metabolism ; Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/antagonists & inhibitors

  • Source: Scientific reports [Sci Rep] 2024 Nov 02; Vol. 14 (1), pp. 26431. Date of Electronic Publication: 2024 Nov 02.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Synthesis and biological evaluation of novel aminoquinolines with an n-octyl linker: Impact of halogen substituents on C(7) or a terminal amino group on anticholinesterase and BACE1 activity.

  • Authors : Matošević A; Institute for Medical Research and Occupational Health, Ksaverska cesta 2, 10000 Zagreb, Croatia.; Bartolić M

Subjects: Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/metabolism ; Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/antagonists & inhibitors ; Cholinesterase Inhibitors*/Cholinesterase Inhibitors*/Cholinesterase Inhibitors*/pharmacology

  • Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2024 Nov 01; Vol. 112, pp. 129928. Date of Electronic Publication: 2024 Aug 14.Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Autoantibodies to BACE1 promote Aβ accumulation and neurodegeneration in Alzheimer's disease.

  • Authors : Wang YR; Department of Neurology and Centre for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, China.; Key Laboratory of Aging and Brain Disease, Chongqing, China.

Subjects: Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/metabolism ; Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/immunology ; Alzheimer Disease*/Alzheimer Disease*/Alzheimer Disease*/immunology

  • Source: Acta neuropathologica [Acta Neuropathol] 2024 Oct 24; Vol. 148 (1), pp. 57. Date of Electronic Publication: 2024 Oct 24.Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0412041 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-0533

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Academic Journal

Clarifying the association of CSF Aβ, tau, BACE1, and neurogranin with AT(N) stages in Alzheimer disease.

Subjects: Alzheimer Disease*/Alzheimer Disease*/Alzheimer Disease*/cerebrospinal fluid ; tau Proteins*/tau Proteins*/tau Proteins*/cerebrospinal fluid ; Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/cerebrospinal fluid

  • Source: Molecular neurodegeneration [Mol Neurodegener] 2024 Oct 08; Vol. 19 (1), pp. 66. Date of Electronic Publication: 2024 Oct 08.Publisher: BioMed Central Country of Publication: England NLM ID: 101266600 Publication Model: Electronic Cited Medium: Internet ISSN: 1750-1326

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Academic Journal

Molecular mechanism underlying effect of D93 and D289 protonation states on inhibitor-BACE1 binding: exploration from multiple independent Gaussian accelerated molecular dynamics and deep learning.

  • Authors : Du J; Center for Medical Artificial Intelligence, Shandong University of Traditional Chinese Medicine, Qingdao, China.; Xu G

Subjects: Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/antagonists & inhibitors ; Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/chemistry ; Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/metabolism

  • Source: SAR and QSAR in environmental research [SAR QSAR Environ Res] 2024 Oct; Vol. 35 (10), pp. 919-947. Date of Electronic Publication: 2024 Nov 08.Publisher: Taylor & Francis Country of Publication: England NLM ID: 9440156 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Myeloid ectopic viral integration site 2 accelerates the progression of Alzheimer's disease.

  • Authors : Cui Y; Clinical Laboratory of Xuanwu Hospital, Capital Medical University, Beijing, People's Republic of China.; Zhang X

Subjects: Alzheimer Disease*/Alzheimer Disease*/Alzheimer Disease*/metabolism ; Alzheimer Disease*/Alzheimer Disease*/Alzheimer Disease*/genetics ; Alzheimer Disease*/Alzheimer Disease*/Alzheimer Disease*/pathology

  • Source: Aging cell [Aging Cell] 2024 Oct; Vol. 23 (10), pp. e14260. Date of Electronic Publication: 2024 Jul 12.Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101130839 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Identifying β-secretase 1 (BACE1) inhibitors from plant-based compounds: an approach targeting Alzheimer's therapeutics employing molecular docking and dynamics simulation.

  • Authors : Alrouji M; Department of Medical Laboratories, College of Applied Medical Sciences, Shaqra University, 11961, Shaqra, Saudi Arabia.; Alhumaydhi FA

Subjects: Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/antagonists & inhibitors ; Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/chemistry ; Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/metabolism

  • Source: Molecular diversity [Mol Divers] 2024 Oct; Vol. 28 (5), pp. 2967-2980. Date of Electronic Publication: 2023 Sep 20.Publisher: ESCOM Science Publishers Country of Publication: Netherlands NLM ID: 9516534 Publication Model: Print-Electronic Cited Medium: Internet

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  • 1-10 of  1,611 results for ""Amyloid Precursor Protein Secretases""