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Academic Journal

Fast and Reliable Thermodynamic Approach for Determining the Protonation State of the Asp Dyad.

  • Authors : Huang J; School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology , 13 Hangkong Road, Wuhan, Hubei 430030, P.R. China.; Sun B

Subjects: Aspartic Acid* ; Protons* ; Quantum Theory*

  • Source: Journal of chemical information and modeling [J Chem Inf Model] 2017 Sep 25; Vol. 57 (9), pp. 2273-2280. Date of Electronic Publication: 2017 Sep 15.Publisher: American Chemical Society Country of Publication: United States NLM ID: 101230060 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Asp32 and Asp228 determine the selective inhibition of BACE1 as shown by docking and molecular dynamics simulations.

  • Authors : Hernández-Rodríguez M; Laboratorio de Modelado Molecular y Bioinformática y diseño de farmaos, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón s/n, 11340 México D.F, Mexico; Laboratorio de Biofísica y Biocatálisis, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón s/n, 11340 México D.F, Mexico

Subjects: Aspartic Acid* ; Molecular Docking Simulation* ; Molecular Dynamics Simulation*

  • Source: European journal of medicinal chemistry [Eur J Med Chem] 2016 Nov 29; Vol. 124, pp. 1142-1154. Date of Electronic Publication: 2016 Aug 16.Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates.

  • Authors : Bowers S; Department of Chemical Sciences, Elan Pharmaceuticals, 180 Oyster Point Boulevard, South San Francisco, CA 94080, USA. ; Xu YZ

Subjects: Drug Design*; Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/*antagonists & inhibitors ; Aspartic Acid/Aspartic Acid/Aspartic Acid/*chemistry

  • Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2013 Apr 01; Vol. 23 (7), pp. 2181-6. Date of Electronic Publication: 2013 Feb 04.Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

SAR of tertiary carbinamine derived BACE1 inhibitors: role of aspartate ligand amine pKa in enzyme inhibition.

  • Authors : Rajapakse HA; Department of Medicinal Chemistry, Merck Research Laboratories, West Point, PA 19486, USA. ; Nantermet PG

Subjects: Amines/Amines/Amines/*metabolism ; Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/*antagonists & inhibitors ; Aspartic Acid/Aspartic Acid/Aspartic Acid/*metabolism

  • Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2010 Mar 15; Vol. 20 (6), pp. 1885-9. Date of Electronic Publication: 2010 Feb 04.Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Crystallographic evidence for noncoplanar catalytic aspartic acids in plasmepsin II resides in the Protein Data Bank.

  • Authors : Robbins AH; Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, FL 32610, USA.; Dunn BM

Subjects: Aspartic Acid/Aspartic Acid/Aspartic Acid/*chemistry ; Aspartic Acid Endopeptidases/Aspartic Acid Endopeptidases/Aspartic Acid Endopeptidases/*chemistry ; Plasmodium falciparum/Plasmodium falciparum/Plasmodium falciparum/*enzymology

  • Source: Acta crystallographica. Section D, Biological crystallography [Acta Crystallogr D Biol Crystallogr] 2009 Mar; Vol. 65 (Pt 3), pp. 294-6. Date of Electronic Publication: 2009 Feb Publisher: Wiley-Blackwell Country of Publication: United States NLM ID: 9305878 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Potent memapsin 2 (beta-secretase) inhibitors: design, synthesis, protein-ligand X-ray structure, and in vivo evaluation.

Subjects: Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/*antagonists & inhibitors ; Aspartic Acid/Aspartic Acid/Aspartic Acid/*analogs & derivatives ; Aspartic Acid Endopeptidases/Aspartic Acid Endopeptidases/Aspartic Acid Endopeptidases/*antagonists & inhibitors

  • Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2008 Feb 01; Vol. 18 (3), pp. 1031-6. Date of Electronic Publication: 2008 Jan 03.Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

The protonation state of the catalytic aspartates in plasmepsin II.

  • Authors : Friedman R; Department of Biochemistry, University of Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland. ; Caflisch A

Subjects: Computer Simulation* ; Models, Molecular* ; Protons*

  • Source: FEBS letters [FEBS Lett] 2007 Aug 21; Vol. 581 (21), pp. 4120-4. Date of Electronic Publication: 2007 Jul 25.Publisher: John Wiley & Sons Ltd Country of Publication: England NLM ID: 0155157 Publication Model: Print-Electronic Cited Medium: Print ISSN:

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Academic Journal

Mammalian D-aspartyl endopeptidase: a scavenger for noxious racemized proteins in aging.

  • Authors : Kinouchi T; Department of Biochemistry, Jichi Medical School, 329-0498, Tochigi, Japan. ; Ishiura S

Subjects: Aging/Aging/Aging/*metabolism ; Aspartic Acid/Aspartic Acid/Aspartic Acid/*metabolism ; Aspartic Acid Endopeptidases/Aspartic Acid Endopeptidases/Aspartic Acid Endopeptidases/*metabolism

  • Source: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2004 Feb 13; Vol. 314 (3), pp. 730-6.Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print Cited Medium: Print ISSN: 0006-291X (Print)

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Academic Journal

Identification of a glutamic acid and an aspartic acid residue essential for catalytic activity of aspergillopepsin II, a non-pepsin type acid proteinase.

  • Authors : Huang XP; School of Life Science, Tokyo University of Pharmacy and Life Science, Hachioji, Tokyo 192-0392, Japan.; Kagami N

Subjects: Aspartic Acid/Aspartic Acid/Aspartic Acid/*analysis ; Aspartic Acid Endopeptidases/Aspartic Acid Endopeptidases/Aspartic Acid Endopeptidases/*metabolism ; Glutamic Acid/Glutamic Acid/Glutamic Acid/*analysis

  • Source: The Journal of biological chemistry [J Biol Chem] 2000 Aug 25; Vol. 275 (34), pp. 26607-14.Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication

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Academic Journal

Alkylation of a catalytic aspartate group of the SIV protease by an epoxide inhibitor.

  • Authors : Caldera PS; Department of Pharmaceutical Chemistry, School of Pharmacy, University of California, San Francisco 94143-0446, USA.; Yu Z

Subjects: Antiviral Agents/Antiviral Agents/Antiviral Agents/*pharmacology ; Aspartic Acid/Aspartic Acid/Aspartic Acid/*metabolism ; Aspartic Acid Endopeptidases/Aspartic Acid Endopeptidases/Aspartic Acid Endopeptidases/*antagonists & inhibitors

  • Source: Bioorganic & medicinal chemistry [Bioorg Med Chem] 1997 Nov; Vol. 5 (11), pp. 2019-27.Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print Cited Medium: Print ISSN: 0968-0896 (Print)

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  • 1-10 of  111 results for ""Aspartic Acid Proteases""