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Academic Journal

Design, synthesis and cytotoxic evaluation of new thieno[2,3-d]pyrimidine analogues as VEGFR-2/AKT dual inhibitors, apoptosis and autophagy inducers.

  • Authors : Abd El-Mawgoud HK; Chemistry Department, Faculty of Women for Arts, Science and Education, Ain Shams University, Heliopolis, 11767 Cairo, Egypt. Electronic address: .; AboulMagd AM

Subjects: Vascular Endothelial Growth Factor Receptor-2*/Vascular Endothelial Growth Factor Receptor-2*/Vascular Endothelial Growth Factor Receptor-2*/antagonists & inhibitors ; Vascular Endothelial Growth Factor Receptor-2*/Vascular Endothelial Growth Factor Receptor-2*/Vascular Endothelial Growth Factor Receptor-2*/metabolism ; Pyrimidines*/Pyrimidines*/Pyrimidines*/pharmacology

  • Source: Bioorganic chemistry [Bioorg Chem] 2024 Sep; Vol. 150, pp. 107622. Date of Electronic Publication: 2024 Jul 09.Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Novel isoniazid-hydrazone derivatives induce cell growth inhibition, cell cycle arrest and apoptosis via mitochondria-dependent caspase activation and PI3K/AKT inhibition.

  • Authors : Rouzi K; Laboratory of Analytical Chemistry and Bromatology, Team of Formulation and Quality Control of Health Products, Faculty of Medicine and Pharmacy, Mohammed V University in Rabat, Morocco.; Altay A

Subjects: Proto-Oncogene Proteins c-akt*/Proto-Oncogene Proteins c-akt*/Proto-Oncogene Proteins c-akt*/metabolism ; Proto-Oncogene Proteins c-akt*/Proto-Oncogene Proteins c-akt*/Proto-Oncogene Proteins c-akt*/antagonists & inhibitors ; Apoptosis*/Apoptosis*/Apoptosis*/drug effects

  • Source: Bioorganic chemistry [Bioorg Chem] 2024 Sep; Vol. 150, pp. 107563. Date of Electronic Publication: 2024 Jun 13.Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

TBC1D10B promotes tumor progression in colon cancer via PAK4‑mediated promotion of the PI3K/AKT/mTOR pathway.

  • Authors : Chi XJ; Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, Key Laboratory of Clinical Laboratory Medicine of Guangxi Department of Education, Guangxi Zhuang Autonomous Region, 6 Shuangyong Road, Nanning, 530021, China.; Song YB

Subjects: Apoptosis*/Apoptosis*/Apoptosis*/genetics ; Cell Movement*/Cell Movement*/Cell Movement*/genetics ; Cell Proliferation*/Cell Proliferation*/Cell Proliferation*/genetics

  • Source: Apoptosis : an international journal on programmed cell death [Apoptosis] 2024 Aug; Vol. 29 (7-8), pp. 1185-1197. Date of Publisher: Springer Country of Publication: Netherlands NLM ID: 9712129 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Hydrolyzed Chicken Meat Extract and Its Bioactive Cyclopeptides Protect Neural Function by Attenuating Inflammation and Apoptosis via PI3K/AKT and AMPK Pathways.

  • Authors : Ni Y; College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310032, China.; Wang Z

Subjects: Proto-Oncogene Proteins c-akt*/Proto-Oncogene Proteins c-akt*/Proto-Oncogene Proteins c-akt*/metabolism ; Proto-Oncogene Proteins c-akt*/Proto-Oncogene Proteins c-akt*/Proto-Oncogene Proteins c-akt*/genetics ; Phosphatidylinositol 3-Kinases*/Phosphatidylinositol 3-Kinases*/Phosphatidylinositol 3-Kinases*/metabolism

  • Source: Journal of agricultural and food chemistry [J Agric Food Chem] 2024 Jul 31; Vol. 72 (30), pp. 16708-16725. Date of Electronic Publication: 2024 Jul 17.Publisher: American Chemical Society Country of Publication: United States NLM ID: 0374755 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Biological impact and therapeutic potential of a novel camptothecin derivative (FLQY2) in pancreatic cancer through inactivation of the PDK1/AKT/mTOR pathway.

  • Authors : Wang W; College of Pharmaceutical Sciences, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Key Laboratory of Marine Fishery Resources Exploitment, Zhejiang Province, China.; Xiong H

Subjects: Pancreatic Neoplasms*/Pancreatic Neoplasms*/Pancreatic Neoplasms*/drug therapy ; Pancreatic Neoplasms*/Pancreatic Neoplasms*/Pancreatic Neoplasms*/pathology ; Pancreatic Neoplasms*/Pancreatic Neoplasms*/Pancreatic Neoplasms*/metabolism

  • Source: Bioorganic chemistry [Bioorg Chem] 2024 Jul; Vol. 148, pp. 107436. Date of Electronic Publication: 2024 May 08.Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Azaphilone pigments from the marine-derived Penicillium sclerotium UJNMF 0503 and their neuroprotective potential against H 2 O 2 -induced cell apoptosis through modulating PI3K/Akt pathway.

  • Authors : Bao J; School of Biological Science and Technology, University of Jinan, 336 West Road of Nan Xinzhuang, Jinan 250022, China.; Zhao YF

Subjects: Apoptosis*/Apoptosis*/Apoptosis*/drug effects ; Penicillium*/Penicillium*/Penicillium*/chemistry ; Neuroprotective Agents*/Neuroprotective Agents*/Neuroprotective Agents*/pharmacology

  • Source: Bioorganic chemistry [Bioorg Chem] 2024 Jul; Vol. 148, pp. 107434. Date of Electronic Publication: 2024 May 08.Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Da-Chai-Hu-Tang Formula inhibits the progression and metastasis in HepG2 cells through modulation of the PI3K/AKT/STAT3-induced cell cycle arrest and apoptosis.

  • Authors : Duan ZW; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 102488, China. Electronic address: .; Liu Y

Subjects: STAT3 Transcription Factor*/STAT3 Transcription Factor*/STAT3 Transcription Factor*/metabolism ; Apoptosis*/Apoptosis*/Apoptosis*/drug effects ; Proto-Oncogene Proteins c-akt*/Proto-Oncogene Proteins c-akt*/Proto-Oncogene Proteins c-akt*/metabolism

  • Source: Journal of ethnopharmacology [J Ethnopharmacol] 2024 Sep 15; Vol. 331, pp. 118293. Date of Electronic Publication: 2024 May 03.Publisher: Elsevier Sequoia Country of Publication: Ireland NLM ID: 7903310 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Promotion of apoptosis in melanoma cells by taxifolin through the PI3K/AKT signaling pathway: Screening of natural products using WGCNA and CMAP platforms.

  • Authors : Wang Y; School of Clinical Medicine, Guizhou Medical University, No.9 Beijing Road, Yunyan District, Guiyang 550004, Guizhou, China.; Chen SJ

Subjects: Quercetin*/Quercetin*/Quercetin*/analogs & derivatives ; Quercetin*/Quercetin*/Quercetin*/pharmacology ; Quercetin*/Quercetin*/Quercetin*/therapeutic use

  • Source: International immunopharmacology [Int Immunopharmacol] 2024 Sep 10; Vol. 138, pp. 112517. Date of Electronic Publication: 2024 Jun 25.Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100965259 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Glucose fluctuations aggravate cardiomyocyte apoptosis by enhancing the interaction between Txnip and Akt.

  • Authors : Zhang ZY; Department of Cardiology, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi, 214023, China.; Pan L

Subjects: Myocytes, Cardiac*/Myocytes, Cardiac*/Myocytes, Cardiac*/pathology ; Myocytes, Cardiac*/Myocytes, Cardiac*/Myocytes, Cardiac*/metabolism ; Myocytes, Cardiac*/Myocytes, Cardiac*/Myocytes, Cardiac*/drug effects

  • Source: BMC cardiovascular disorders [BMC Cardiovasc Disord] 2024 Sep 03; Vol. 24 (1), pp. 470. Date of Electronic Publication: 2024 Sep 03.Publisher: BioMed Central Country of Publication: England NLM ID: 100968539 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2261

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Academic Journal

Pretreatment with Dan-Shen-Yin granules alleviates ethanol-induced gastric mucosal damage in rats by inhibiting oxidative stress and apoptosis via Akt/Nrf2 signaling pathway.

  • Authors : Zhao Z; Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Centre for Pharmaceutical Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.; Wei G

Subjects: Oxidative Stress*/Oxidative Stress*/Oxidative Stress*/drug effects ; Ethanol* ; Apoptosis*/Apoptosis*/Apoptosis*/drug effects

  • Source: Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2024 Sep; Vol. 132, pp. 155866. Date of Electronic Publication: 2024 Jul 09.Publisher: Urban & Fischer Verlag Country of Publication: Germany NLM ID: 9438794 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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  • 1-10 of  5,401 results for ""Proto-Oncogene Proteins c-akt""