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Academic Journal

DFT, Molecular Docking, ADME, and Cardiotoxicity Studies of Persuasive Thiazoles as Potential Inhibitors of the Main Protease of SARS-CoV-2.

  • Authors : Khan MA; School of Chemistry and Chemical Engineering, Linyi University, Linyi, 276005, China.; Mutahir S

Subjects: Molecular Docking Simulation* ; SARS-CoV-2*/SARS-CoV-2*/SARS-CoV-2*/drug effects ; Thiazoles*/Thiazoles*/Thiazoles*/chemistry

  • Source: Chemistry & biodiversity [Chem Biodivers] 2024 Dec; Vol. 21 (12), pp. e202401775. Date of Electronic Publication: 2024 Oct 22.Publisher: Verlag Helvetica Chimica Acta Country of Publication: Switzerland NLM ID: 101197449 Publication Model: Print-Electronic Cited Medium:

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Academic Journal

Synthesis, characterization, molecular docking, pharmacokinetics, and molecular dynamics of new bis-thiazoles based on bis-thiosemicarbazone as anti-coxsackievirus.

  • Authors : Farghaly TA; Department of Chemistry, Faculty of Science, Cairo University, Giza, 12613, Egypt.; Abbas EMH

Subjects: Antiviral Agents*/Antiviral Agents*/Antiviral Agents*/pharmacology ; Antiviral Agents*/Antiviral Agents*/Antiviral Agents*/chemistry ; Antiviral Agents*/Antiviral Agents*/Antiviral Agents*/chemical synthesis

  • Source: Scientific reports [Sci Rep] 2024 Nov 26; Vol. 14 (1), pp. 29378. Date of Electronic Publication: 2024 Nov 26.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

4-Substituted-2-Thiazole Amides as Viral Replication Inhibitors of Alphaviruses.

  • Authors : Garzan A; Scientific Platforms Division, Southern Research, 2000 ninth Avenue South, Birmingham, Alabama 35205, United States.; Ahmed SK

Subjects: Virus Replication*/Virus Replication*/Virus Replication*/drug effects ; Antiviral Agents*/Antiviral Agents*/Antiviral Agents*/pharmacology ; Antiviral Agents*/Antiviral Agents*/Antiviral Agents*/chemistry

  • Source: Journal of medicinal chemistry [J Med Chem] 2024 Dec 12; Vol. 67 (23), pp. 20858-20878. Date of Electronic Publication: 2024 Dec 02.Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

High-throughput screening unveils nitazoxanide as a potent PRRSV inhibitor by targeting NMRAL1.

  • Authors : Cui Z; State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, 730000, China.; Liu J

Subjects: Porcine respiratory and reproductive syndrome virus*/Porcine respiratory and reproductive syndrome virus*/Porcine respiratory and reproductive syndrome virus*/drug effects ; Nitro Compounds*/Nitro Compounds*/Nitro Compounds*/pharmacology ; Antiviral Agents*/Antiviral Agents*/Antiviral Agents*/pharmacology

  • Source: Nature communications [Nat Commun] 2024 Jun 06; Vol. 15 (1), pp. 4813. Date of Electronic Publication: 2024 Jun 06.Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Impairment of SARS-CoV-2 spike glycoprotein maturation and fusion activity by nitazoxanide: an effect independent of spike variants emergence.

  • Authors : Riccio A; Department of Biology, University of Rome Tor Vergata, Rome, Italy.; Santopolo S

Subjects: Antiviral Agents*/Antiviral Agents*/Antiviral Agents*/pharmacology ; Nitro Compounds*/Nitro Compounds*/Nitro Compounds*/pharmacology ; SARS-CoV-2*/SARS-CoV-2*/SARS-CoV-2*/drug effects SARS-CoV-2 variants

  • Source: Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2022 Apr 07; Vol. 79 (5), pp. 227. Date of Electronic Publication: 2022 Apr 07.Publisher: Springer Country of Publication: Switzerland NLM ID: 9705402 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-9071

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Academic Journal

Potential COVID-19 Drug Candidates Based on Diazinyl-Thiazol-Imine Moieties: Synthesis and Greener Pastures Biological Study.

  • Authors : Abu-Melha S; Department of Chemistry, Faculty of Science, King Khalid University, Abha 61413, Saudi Arabia.; Edrees MM

Subjects: COVID-19 Drug Treatment*; Antiviral Agents/Antiviral Agents/Antiviral Agents/*chemistry ; Imines/Imines/Imines/*chemistry

  • Source: Molecules (Basel, Switzerland) [Molecules] 2022 Jan 13; Vol. 27 (2). Date of Electronic Publication: 2022 Jan 13.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049

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Academic Journal

Discovery of highly potent SARS-CoV-2 M pro inhibitors based on benzoisothiazolone scaffold.

  • Authors : Chen W; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, China; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.

Subjects: Drug Discovery*; Antiviral Agents/Antiviral Agents/Antiviral Agents/*pharmacology ; Coronavirus 3C Proteases/Coronavirus 3C Proteases/Coronavirus 3C Proteases/*antagonists & inhibitors

  • Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2022 Feb 15; Vol. 58, pp. 128526. Date of Electronic Publication: 2022 Jan 05.Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Synthesis, antiviral activity, preliminary pharmacokinetics and structural parameters of thiazolide amine salts.

  • Authors : Stachulski AV; Department of Chemistry, Robert Robinson Laboratories, University of Liverpool, Liverpool, L69 7ZD, UK.; Rossignol JF

Subjects: Amines/Amines/Amines/*pharmacology ; Antiviral Agents/Antiviral Agents/Antiviral Agents/*pharmacology ; Influenza A virus/Influenza A virus/Influenza A virus/*drug effects

  • Source: Future medicinal chemistry [Future Med Chem] 2021 Oct; Vol. 13 (20), pp. 1731-1741. Date of Electronic Publication: 2021 Aug 17.Publisher: Future Science Country of Publication: England NLM ID: 101511162 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

The Thiazole-5-Carboxamide GPS491 Inhibits HIV-1, Adenovirus, and Coronavirus Replication by Altering RNA Processing/Accumulation.

  • Authors : Dahal S; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.; Cheng R

Subjects: Adenoviridae/Adenoviridae/Adenoviridae/*drug effects ; Antiviral Agents/Antiviral Agents/Antiviral Agents/*pharmacology ; Coronavirus/Coronavirus/Coronavirus/*drug effects

  • Source: Viruses [Viruses] 2021 Dec 30; Vol. 14 (1). Date of Electronic Publication: 2021 Dec 30.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101509722 Publication Model: Electronic Cited Medium: Internet ISSN: 1999-4915

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Academic Journal

Bithiazole Inhibitors of Phosphatidylinositol 4-Kinase (PI4KIIIβ) as Broad-Spectrum Antivirals Blocking the Replication of SARS-CoV-2, Zika Virus, and Human Rhinoviruses.

  • Authors : Grazia Martina M; Dipartimento di Scienze degli Alimenti e del Farmaco, Università degli Studi di Parma, Parco Area delle Scienze, 27/A, 43124, Parma, Italy.; Vicenti I

Subjects: 1-Phosphatidylinositol 4-Kinase/1-Phosphatidylinositol 4-Kinase/1-Phosphatidylinositol 4-Kinase/*antagonists & inhibitors ; Antiviral Agents/Antiviral Agents/Antiviral Agents/*pharmacology ; Enzyme Inhibitors/Enzyme Inhibitors/Enzyme Inhibitors/*chemistry

  • Source: ChemMedChem [ChemMedChem] 2021 Dec 06; Vol. 16 (23), pp. 3548-3552. Date of Electronic Publication: 2021 Sep 07.Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101259013 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1860-7187

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  • 1-10 of  651 results for ""THIAZOLES""