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Academic Journal

Discovery of Imidazo[1,2- a ]pyrazine Derivatives as Potent ENPP1 Inhibitors.

  • Authors : Zhan S; Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan 528400, China.; School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou 511436, China.

Subjects: Pyrazines*/Pyrazines*/Pyrazines*/pharmacology ; Pyrazines*/Pyrazines*/Pyrazines*/chemistry ; Pyrazines*/Pyrazines*/Pyrazines*/chemical synthesis

  • Source: Journal of medicinal chemistry [J Med Chem] 2024 Oct 24; Vol. 67 (20), pp. 18317-18333. Date of Electronic Publication: 2024 Oct 02.Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Discovery of a potent Gilteritinib-based FLT3-PROTAC degrader for the treatment of Acute myeloid leukemia.

  • Authors : Ye L; Jiangsu Key Laboratory for Functional Substance of Chinese Medicine, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, PR China.; Cui Z

Subjects: fms-Like Tyrosine Kinase 3*/fms-Like Tyrosine Kinase 3*/fms-Like Tyrosine Kinase 3*/antagonists & inhibitors ; fms-Like Tyrosine Kinase 3*/fms-Like Tyrosine Kinase 3*/fms-Like Tyrosine Kinase 3*/metabolism ; Leukemia, Myeloid, Acute*/Leukemia, Myeloid, Acute*/Leukemia, Myeloid, Acute*/drug therapy

  • Source: Bioorganic chemistry [Bioorg Chem] 2024 Aug; Vol. 149, pp. 107477. Date of Electronic Publication: 2024 May 19.Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Prevention of allergic reactions during oxaliplatin desensitization through inhibition of Bruton tyrosine kinase.

  • Authors : Erickson KA; Division of Allergy and Immunology, Northwestern Medicine, Chicago, Ill.; Norton JE

Subjects: Oxaliplatin*/Oxaliplatin*/Oxaliplatin*/adverse effects ; Drug Hypersensitivity*/Drug Hypersensitivity*/Drug Hypersensitivity*/immunology ; Drug Hypersensitivity*/Drug Hypersensitivity*/Drug Hypersensitivity*/prevention & control

  • Source: The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2024 Jul; Vol. 154 (1), pp. 222-228.e4. Date of Electronic Publication: 2024 Mar 21.Publisher: Mosby Country of Publication: United States NLM ID: 1275002 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-6825

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Academic Journal

A Novel Tetramethylpyrazine Chalcone Hybrid- HCTMPPK, as a Potential Anti-Lung Cancer Agent by Downregulating MELK.

  • Authors : Ma Y; Qingdao Key Laboratory of Common Diseases, Qingdao Municipal Hospital, School of Medicine and Pharmacy, Ocean University of China, Qingdao, Shandong, 260071, People's Republic of China.; Department of Respiratory and Critical Care Medicine, Qingdao Municipal Hospital, University of Health and Rehabilitation Sciences, Qingdao, 266071, People's Republic of China.

Subjects: Antineoplastic Agents*/Antineoplastic Agents*/Antineoplastic Agents*/pharmacology ; Antineoplastic Agents*/Antineoplastic Agents*/Antineoplastic Agents*/chemistry ; Chalcone*/Chalcone*/Chalcone*/pharmacology

  • Source: Drug design, development and therapy [Drug Des Devel Ther] 2024 May 07; Vol. 18, pp. 1531-1546. Date of Electronic Publication: 2024 May 07 (Print Publication: 2024).Publisher: Dove Press Limited Country of Publication: New Zealand NLM ID: 101475745 Publication Model: eCollection Cited Medium: Internet ISSN:

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Academic Journal

Cisplatin and Procaterol Combination in Gastric Cancer? Targeting Checkpoint Kinase 1 for Cancer Drug Discovery and Repurposing by an Integrated Computational and Experimental Approach.

  • Authors : Giridhara Prema S; Center for Systems Biology and Molecular Medicine, Yenepoya Research Centre, Yenepoya (Deemed to be University), Mangalore, India.; Chandrasekaran J

Subjects: Stomach Neoplasms*/Stomach Neoplasms*/Stomach Neoplasms*/drug therapy ; Antineoplastic Agents*/Antineoplastic Agents*/Antineoplastic Agents*/pharmacology ; Pyrazines*

  • Source: Omics : a journal of integrative biology [OMICS] 2024 Jan; Vol. 28 (1), pp. 8-23. Date of Electronic Publication: 2024 Jan 08.Publisher: Mary Ann Liebert, Inc Country of Publication: United States NLM ID: 101131135 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Possible nonimmunological toxicological mechanisms of vesnarinone-associated agranulocytosis in HL-60 cells: role of reduced glutathione as cytotoxic defense.

  • Authors : Koga T; Department of Drug Metabolism and Pharmacokinetics, Nonclinical Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.; Sahara Y

Subjects: Agranulocytosis*/Agranulocytosis*/Agranulocytosis*/chemically induced ; Antineoplastic Agents* ; Pyrazines*

  • Source: The Journal of toxicological sciences [J Toxicol Sci] 2024; Vol. 49 (3), pp. 95-103.Publisher: Doku Sayō Kenkyūkai Country of Publication: Japan NLM ID: 7805798 Publication Model: Print Cited Medium: Internet ISSN: 1880-3989

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Academic Journal

Design, Synthesis, and Biological Evaluation of Two Series of Novel A-Ring Fused Steroidal Pyrazines as Potential Anticancer Agents.

  • Authors : Wang S; College of Chemistry & Pharmacy, Northwest A&F University, 22 Xinong Road, Yangling 712100, Shannxi, China.; Yuan X

Subjects: Drug Design*; Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*chemical synthesis ; Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*pharmacology

  • Source: International journal of molecular sciences [Int J Mol Sci] 2020 Feb 28; Vol. 21 (5). Date of Electronic Publication: 2020 Feb 28.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

Catalyst-Free One-Pot Synthesis of Densely Substituted Pyrazole-Pyrazines as Anti-Colorectal Cancer Agents.

  • Authors : Xu J; College of Pharmacy, National & Local Joint Engineering Research Center of Targeted and Innovative Therapeutics, Chongqing Key Laboratory of Kinase Modulators as Innovative Medicine, Chongqing University of Arts and Sciences, Chongqing, 402160, China.; Tan HB

Subjects: Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*chemical synthesis ; Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*pharmacology ; Colorectal Neoplasms/Colorectal Neoplasms/Colorectal Neoplasms/*drug therapy

  • Source: Scientific reports [Sci Rep] 2020 Jun 09; Vol. 10 (1), pp. 9281. Date of Electronic Publication: 2020 Jun 09.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Low-Molecular Pyrazine-Based DNA Binders: Physicochemical and Antimicrobial Properties.

  • Authors : Mech-Warda P; Department of Bioinorganic Chemistry, Faculty of Chemistry, University of Gdańsk, Wita Stwosza 63, 80-308 Gdańsk, Poland.; Giełdoń A

Subjects: Antineoplastic Agents*/Antineoplastic Agents*/Antineoplastic Agents*/chemistry ; Pyrazines*/Pyrazines*/Pyrazines*/chemistry ; Pyrazines*/Pyrazines*/Pyrazines*/pharmacology

  • Source: Molecules (Basel, Switzerland) [Molecules] 2022 Jun 09; Vol. 27 (12). Date of Electronic Publication: 2022 Jun 09.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049

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Academic Journal

QSAR Studies and Structure Property/Activity Relationships Applied in Pyrazine Derivatives as Antiproliferative Agents Against the BGC823.

Subjects: Quantitative Structure-Activity Relationship*; Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*chemistry ; Pyrazines/Pyrazines/Pyrazines/*chemistry

  • Source: Acta chimica Slovenica [Acta Chim Slov] 2021 Dec 15; Vol. 68 (4), pp. 882-895. Date of Electronic Publication: 2021 Dec 15.Publisher: Slovenian Chemical Society Country of Publication: Slovenia NLM ID: 101247110 Publication Model: Electronic Cited Medium: Internet ISSN:

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  • 1-10 of  1,865 results for ""PYRAZINES""