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Academic Journal

Discovery of a nanomolar inhibitor of the human glyoxalase-I enzyme using structure-based poly-pharmacophore modelling and molecular docking.

  • Authors : Al-Shar'i NA; Department of Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy, Jordan University of Science and Technology, P.O. Box 3030, Irbid, 22110, Jordan. .; Al-Balas QA

Subjects: Structure-Activity Relationship*; Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*chemistry ; Enzyme Inhibitors/Enzyme Inhibitors/Enzyme Inhibitors/*chemistry

  • Source: Journal of computer-aided molecular design [J Comput Aided Mol Des] 2019 Sep; Vol. 33 (9), pp. 799-815. Date of Electronic Publication: 2019 Oct 19.Publisher: Springer Country of Publication: Netherlands NLM ID: 8710425 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Synthesis and Structure-Activity Relationships of 4-Morpholino-7,8-Dihydro-5H-Thiopyrano[4,3-d]pyrimidine Derivatives Bearing Pyrazoline Scaffold.

  • Authors : Wang Q; Jiangxi Provincial Key Laboratory of Drug Design and Evaluation, School of Pharmacy, Jiangxi Science & Technology Normal University, Nanchang 330013, China. .; Li X

Subjects: Structure-Activity Relationship*; Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*chemistry ; Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*pharmacology

  • Source: Molecules (Basel, Switzerland) [Molecules] 2017 Oct 31; Vol. 22 (11). Date of Electronic Publication: 2017 Oct 31.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049

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Academic Journal

Medicinal Perspective of Indole Derivatives: Recent Developments and Structure-Activity Relationship Studies.

  • Authors : Kumar D; Department of Pharmaceutical Chemistry, ISF College of Pharmacy, Ghal Kalan, G.T Road, Moga, Punjab, 142001, India.; Sharma S

Subjects: Structure-Activity Relationship*; Indoles/Indoles/Indoles/*chemistry ; Indoles/Indoles/Indoles/*pharmacology

  • Source: Current drug targets [Curr Drug Targets] 2020; Vol. 21 (9), pp. 864-891.Publisher: Bentham Science Publishers Country of Publication: United Arab Emirates NLM ID: 100960531 Publication Model: Print Cited Medium: Internet

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Academic Journal

The Synthesis, Characterization, Cytotoxic Activity Assessment and Structure-Activity Relationship of 4-Aryl-6-(2,5-dichlorothiophen-3-yl)-2-methoxypyridine-3-carbonitriles.

  • Authors : Al-Refai M; Department of Chemistry, Faculty of Science, Al al-Bayt University, P.O.BOX 130040, Al-Mafraq 25113, Jordan.; Ibrahim MM

Subjects: Chemistry Techniques, Synthetic* ; Structure-Activity Relationship*; Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*chemical synthesis

  • Source: Molecules (Basel, Switzerland) [Molecules] 2019 Nov 10; Vol. 24 (22). Date of Electronic Publication: 2019 Nov 10.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049

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Academic Journal

Identifying the structure-activity relationship of leelamine necessary for inhibiting intracellular cholesterol transport.

  • Authors : Gowda R; Department of Pharmacology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.; The Penn State Melanoma and Skin Cancer Center, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.

Subjects: Structure-Activity Relationship*; Antineoplastic Agents, Phytogenic/Antineoplastic Agents, Phytogenic/Antineoplastic Agents, Phytogenic/*chemistry ; Cholesterol/Cholesterol/Cholesterol/*chemistry

  • Source: Oncotarget [Oncotarget] 2017 Apr 25; Vol. 8 (17), pp. 28260-28277.Publisher: Impact Journals Country of Publication: United States NLM ID: 101532965 Publication Model: Print Cited Medium: Internet ISSN:

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Academic Journal

Grid-independent Descriptors (GRIND) Analysis and SAR Guided Molecular Docking Studies to Probe Selectivity Profiles of Inhibitors of Multidrug Resistance Transporters ABCB1 and ABCG2.

  • Authors : Shafi T; Jabeen I; Research Center for Modeling and Simulation (RCMS), National University of Sciences and Technology (NUST), Sector H-12, 44000, Islamabad, Pakistan. Select country.

Subjects: Structure-Activity Relationship*; ATP Binding Cassette Transporter, Subfamily G, Member 2/ATP Binding Cassette Transporter, Subfamily G, Member 2/ATP Binding Cassette Transporter, Subfamily G, Member 2/*antagonists & inhibitors ; Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*pharmacology

  • Source: Current cancer drug targets [Curr Cancer Drug Targets] 2017; Vol. 17 (2), pp. 177-190.Publisher: Bentham Science Publishers Country of Publication: Netherlands NLM ID: 101094211 Publication Model: Print Cited Medium: Internet ISSN:

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Academic Journal

Bacterial production and structure-functional validation of a recombinant antigen-binding fragment (Fab) of an anti-cancer therapeutic antibody targeting epidermal growth factor receptor.

  • Authors : Kim JH; Department of Biotechnology, Research Institute (RIBHS) and College of Biomedical and Health Science, Konkuk University, Chungju, Chungbuk, 27478, South Korea.; Sim DW

Subjects: Structure-Activity Relationship*; Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*metabolism ; Cetuximab/Cetuximab/Cetuximab/*metabolism

  • Source: Applied microbiology and biotechnology [Appl Microbiol Biotechnol] 2016 Dec; Vol. 100 (24), pp. 10521-10529. Date of Electronic Publication: 2016 Jul 28.Publisher: Springer International Country of Publication: Germany NLM ID: 8406612 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Structure-activity relationship study of anticancer thymidine-quinoxaline conjugates under the low radiance of long wavelength ultraviolet light for photodynamic therapy.

  • Authors : Zhang D; Department of Nanomedicine and Biopharmaceuticals, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, China.; Liu H

Subjects: Structure-Activity Relationship*; Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*chemistry ; Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*pharmacology

  • Source: European journal of medicinal chemistry [Eur J Med Chem] 2016 Jan 01; Vol. 107, pp. 180-91. Date of Electronic Publication: 2015 Nov 07.Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Revealing quinquennial anticancer journey of morpholine: A SAR based review.

  • Authors : Arshad F; Drug Design & Medicinal Chemistry Lab, Department of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, 110062, India.; Khan MF

Subjects: Structure-Activity Relationship*; Morpholines/Morpholines/Morpholines/*therapeutic use ; Neoplasms/Neoplasms/Neoplasms/*drug therapy

  • Source: European journal of medicinal chemistry [Eur J Med Chem] 2019 Apr 01; Vol. 167, pp. 324-356. Date of Electronic Publication: 2019 Feb 08.Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Carboxyxanthones: Bioactive Agents and Molecular Scaffold for Synthesis of Analogues and Derivatives.

  • Authors : Ribeiro J; Laboratório de Química Orgânica e Farmacêutica, Departamento de Ciências Químicas, Faculdade de Farmácia, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal. .; Veloso C

Subjects: Structure-Activity Relationship*; Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*chemistry ; Xanthones/Xanthones/Xanthones/*chemistry

  • Source: Molecules (Basel, Switzerland) [Molecules] 2019 Jan 05; Vol. 24 (1). Date of Electronic Publication: 2019 Jan 05.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049

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  • 1-10 of  4,653 results for ""ANTINEOPLASTIC agents""